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Cortisol and Prolactin Responses to d-Fenfluramine in Non-depressed Patients with Obsessive-Compulsive Disorder: A Comparison with Depressed and Healthy Controls

Published online by Cambridge University Press:  02 January 2018

James V. Lucey ,
Veronica O'Keane ,
Gerard Butcher ,
Anthony W. Clare  and
Timothy G. Dinan
James V. Lucey*
Affiliation:
Department of Psychiatry, Trinity College Medical School, St James Hospital, Dublin 8, Ireland
Veronica O'Keane
Affiliation:
Trinity College Medical School, Dublin
Gerard Butcher
Affiliation:
Department of Behaviour Therapy, St Patrick's Hospital, Dublin 8, Ireland
Anthony W. Clare
Affiliation:
Trinity College, Dublin, and Medical Director, St Patrick's Hospital, Dublin 8, Ireland
Timothy G. Dinan
Affiliation:
Trinity College Medical School, St James's Hospital, Dublin 8, Ireland
*
∗The Maudsley Hospital, Denmark Hill, London SE5 8AZ
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Abstract

Cortisol and prolactin responses to d-fenfluramine were measured in 10 drug-free normothymic patients with obsessive-compulsive disorder (OCD). The results were compared with these responses in 10 healthy controls and in 10 major depressives. The endocrine responses in OCD were significantly attenuated when compared to the healthy controls; however, the results were not specific to OCD as the depressives' responses were similarly blunted.

Type
Papers
Information
The British Journal of Psychiatry , Volume 161 , Issue 4 , October 1992 , pp. 517 - 521
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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