Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-05T13:03:02.988Z Has data issue: false hasContentIssue false
  • English
  • Français

Correlation of Negative Symptoms in Schizophrenia with Frontal Lobe Parameters on Magnetic Resonance Imaging

Published online by Cambridge University Press:  02 January 2018

P. Williamson ,
D. Pelz ,
H. Merskey ,
S. Morrison  and
P. Conlon
P. Williamson*
Affiliation:
London Psychiatric Hospital, University of Western Ontario
D. Pelz
Affiliation:
University Hospital, University of Western Ontario
H. Merskey
Affiliation:
London Psychiatric Hospital, University of Western Ontario
S. Morrison
Affiliation:
London Psychiatric Hospital
P. Conlon
Affiliation:
Victoria Hospital, University of Western Ontario
*
∗London Psychiatric Hospital, 850 Highbury Avenue, London, Ontario, Canada, N6A 4H1
Get access Rights & Permissions [Opens in a new window]

Abstract

Among 24 chronic schizophrenic patients, the 10 with high ratings for negative symptoms had significantly higher left-frontal: temporal–cortical T2 ratios. This finding was unrelated to age, dose of medication, length of illness or handedness. No T1 or T2 changes were found to be associated with positive symptoms or tardive dyskinesia in the regions examined.

Type
Papers
Information
The British Journal of Psychiatry , Volume 159 , Issue 1 , July 1991 , pp. 130 - 134
Copyright
Copyright © 1991 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andreasen, N. (1984a) Scale for the Assessment of Negative Symptoms. Iowa City: University of Iowa.Google Scholar
Andreasen, N. (1984b) Scale for the Assessment of Positive Symptoms. Iowa City: University of Iowa.Google Scholar
Andreasen, N., Nasrallah, H. A., Dunn, V., et al (1986) Structural abnormalities in the frontal system in schizophrenia: a magnetic resonance imaging study. Archives of General Psychiatry, 43, 136–144.Google Scholar
Benes, F. M., Davidson, J. & Bird, E. D. (1986) Quantitative cytoarchitectural studies of the cerebral cortex of schizophrenics. Archives of General Psychiatry, 43, 31–35.CrossRefGoogle ScholarPubMed
Besson, J. A. O., Corrigan, F. M., Cherryman, G. R., et al (1987) Nuclear magnetic resonance brain imaging in chronic schizophrenia. British Journal of Psychiatry, 150, 161–163.Google Scholar
Besson, J. A. O., Wheatley, D. N., Skinner, E. R., et al (1989) HNMR relaxation times and water content of red blood cells from chronic alcoholic patients during withdrawal. Magnetic Resonance Imaging, 7, 289–291.Google Scholar
Bottomley, P. A., Hardy, C. J., Argersinger, R. E., et al (1987) A review of 1H-nuclear magnetic resonance relaxation in pathology: are T1 and T2 diagnostic? Medical Physics, 14, 1–37.Google Scholar
Brant-Zawadzki, M. (1988) Magnetic resonance: state of the art. Radiology, 166, 1–10.Google Scholar
Chouinard, G., Ross-Chouinard, A., Amiable, L., et al (1980) Extrapyramidal rating scale. Canadian Journal of Neurological Sciences, 1, 233–240.Google Scholar
Cohen, B. M., Buonanno, F., Keck, P. E., et al (1988) Comparison of MRI and CT scans in a group of psychiatric patients. American Journal of Psychiatry, 145, 1084–1088.Google Scholar
Cohen, R., Semple, W., Gross, M., et al (1987) Dysfunction in prefrontal substrate of sustained attention in schizophrenia. Life Sciences, 40, 2031–2039.Google Scholar
Conlon, P. & Trimble, M. P. (1987) Magnetic resonance imaging in psychiatry. Canadian Journal of Psychiatry, 32, 702–712.Google Scholar
Conlon, P., Trimble, D., Rogers, C., et al (1988) Magnetic resonance imaging in epilepsy: a controlled study. Epilepsy Research, 2, 37–43.Google Scholar
Crooks, L. E., Hylton, M., Ortendahl, D. A., et al (1987) The value of relaxation times and density measurements in clinical MRI. Investigative Radiology, 22, 158–169.Google Scholar
Hyman, R. A. & Gorey, M. T. (1988) Imaging strategies for MR of the brain. Radiologic Clinic of North America, 3, 471–503.CrossRefGoogle Scholar
Johnson, G., Ormerod, I. E. C., Barnes, D., et al (1987) Accuracy and precision in the measurement of relaxation times from nuclear magnetic resonance images. British Journal of Radiology, 60, 143–153.Google Scholar
Johnstone, E. C., Crow, T. J., MacMillan, J. F., et al (1986) magnetic resonance study of early schizophrenia. Journal of Neurology, Neurosurgery and Psychiatry, 49, 136–139.Google Scholar
Kelsoe, J. R., Cadet, J. L., Pickar, D., et al (1988) Quantitative neuroanatomy in schizophrenia: a controlled magnetic resonance imaging study. Archives of General Psychiatry, 45, 533–541.Google Scholar
Keshavan, M. S., Pettegrew, J. W., Panchalingam, K., et al (1989) In vivo 3IP nuclear magnetic resonance (NMR) spectroscopy of the frontal lobe metabolism in neuroleptic naive first episode psychoses: preliminary studies. Schizophrenia Research, 2, 122.CrossRefGoogle Scholar
Lee, D., Fox, A., Vinuela, F., et al (1987) Interobserver variation in computed tomography of the brain. Archives of Neurology, 44, 30–31.Google Scholar
Mathew, R. J., Partain, C. L., Prakash, R., et al (1985) A study of the septum pellucidum and corpus callosum in schizophrenia with MR imaging. Acta Psychiatrica Scandinavica, 72, 414–421.Google Scholar
Moscarelli, M., Maffei, C. & Cesana, B. M. (1987) An international perspective on assessment of negative and positive symptoms in schizophrenia. American Journal of Psychiatry, 144, 1595–1598.Google Scholar
Nasrallah, H. A., Andreasen, N. C., Coffman, J. A., et al (1986) A controlled magnetic resonance imaging study of corpus callosum thickness in schizophrenia. Biological Psychiatry, 21, 274–282.Google Scholar
Pogue-Geile, M. F. & Harrow, M. (1985) Negative symptoms in schizophrenia: their longitudinal course and prognostic importance. Schizophrenia Bulletin, 11, 427–441.Google Scholar
Rossi, A., Stratta, P., Gallucci, M., et al (1988a) Brain morphology in schizophrenia by magnetic resonance imaging (MRI). Acta Psychiatrica Scandinavica, 77, 741–745.Google Scholar
Rossi, A., Stratta, P., Gallucci, M., et al (1988b) Standardized magnetic resonance image intensity study in schizophrenia. Psychiatry Research, 25, 223–231.Google Scholar
Rossi, A., Stratta, P., Gallucci, M., et al (1989) Quantification of corpus callosum and ventricles in schizophrenia with nuclear magnetic resonance imaging: a pilot study. American Journal of Psychiatry, 146, 99–101.Google Scholar
Shelton, R. C. & Weinberger, D. R. (1986) Computerised tomography in schizophrenia: a review and synthesis. In Handbook of Schizophrenia. Volume I: The Neurology of Schizophrenia (eds Nasrallah, H. A. & Weinberger, D. R.), pp. 207–250. Amsterdam: Elsevier Science Publishers.Google Scholar
Smith, R. C., Baumgartner, R. & Calderon, M. (1987) Magnetic resonance imaging studies of the brains of schizophrenic patients. Psychiatry Research, 20, 33–46.Google Scholar
Spitzer, R. & Williams, J. (1985) Structured Clinical Interview for DSM–III–R. New York: New York State Psychiatric Institute.Google Scholar
Stratta, P., Rossi, A., Gallucci, M., et al (1989) Hemispheric asymmetries and schizophrenia: a preliminary magnetic resonance imaging study. Biological Psychiatry, 25, 274–284.CrossRefGoogle ScholarPubMed
Suddath, R. L., Casanova, M. F., Goldberg, T. E., et al (1989) Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. American Journal of Psychiatry, 146, 464–472.Google Scholar
Suddath, R. L., Christison, G. W., Torrey, E. F., et al (1990) Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New England Journal of Medicine, 322, 789–794.Google Scholar
Weinberger, D. R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44, 660–669.Google Scholar
Weinberger, D. R., Berman, K. & Illowsky, B. (1988) Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia III: a new cohort and evidence for a monoaminergic mechanism. Archives of General Psychiatry, 45, 609–615.Google Scholar
Williamson, P., Kutcher, S., Cooper, P., et al (1989) Psychological, topographic EEG and CT scan correlates of frontal lobe function in schizophrenia. Psychiatry Research, 29, 137–149.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.