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Corpus Callosum Thickness in Chronic Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Llewellyn B. Bigelow ,
Henry A. Nasrallah  and
Frederick P. Rauscher
Llewellyn B. Bigelow
Affiliation:
Adult Psychiatry Branch, Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032, USA
Henry A. Nasrallah
Affiliation:
Adult Psychiatry Branch, Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032, USA
Frederick P. Rauscher
Affiliation:
Adult Psychiatry Branch, Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C. 20032, USA
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Summary

In an effort at replication of the original report (Rosenthal and Bigelow, 1972) of increased callosal thickness in schizophrenic brains, the corpus callosum was measured in a blind study of 64 brains autopsied between the years 1972 and 1976. Diagnosis was established by independent chart review. The mean corpus callosum mid sections of 21 early onset chronic schizophrenic brains were found to have a significantly greater thickness when compared with 8 subjects with late onset schizophrenia, 13 patients with neurological diagnoses, or 14 patients with other psychiatric diagnoses. These studies, if independently confirmed, should provide an impetus for testing the hypothesis that some chronic schizophrenic patients have an illness associated with a pathological process in the corpus callosum.

Type
Papers
Information
The British Journal of Psychiatry , Volume 142 , Issue 3 , March 1983 , pp. 284 - 287
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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