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Controlled Trial of Sulpiride in Chronic Schizophrenic Patients

Published online by Cambridge University Press:  29 January 2018

J. Guy Edwards ,
John R. Alexander ,
M. S. Alexander ,
Alan Gordon  and
T. Zutchi
J. Guy Edwards
Affiliation:
Department of Psychiatry, Royal South Hants Hospital, Southampton SO9 4PE
John R. Alexander
Affiliation:
School of Mathematics, Statistics and Computing, Thames Polytechnic, London SE18 6PF
M. S. Alexander
Affiliation:
St James Hospital, Leeds LS9 7TF (Knowle Hospital, Fareham, Hants PO17 5NA)
Alan Gordon
Affiliation:
Knowle Hospital
T. Zutchi
Affiliation:
Holloway Sanatorium, Virginia Water, Surrey GU25 4BJ (Knowle Hospital)
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Summary

In a double-blind comparative trial of sulpiride (600–1,800 mg/day) and trifluoperazine (15–45 mg/day) in 38 chronic schizophrenic patients, ratings of therapeutic results and unwanted effects were made at two-weekly interviews during the six weeks treatment period. The results show that sulpiride has neuroleptic properties and a spectrum of therapeutic activity similar to that of trifluoperazine. There was an association between plasma sulpiride levels and therapeutic response after four weeks' treatment.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 6 , December 1980 , pp. 522 - 529
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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References

Amakusa, T. & Majima, T. (1973) Comparison of therapeutic effects of FK-880 and perphenazine in schizophrenia by a double-blind controlled study. Jentendo Medical Journal, 19, 239–249.Google Scholar
Bellomo, L. E. & Fernandez, H. (1972) Investigation a ‘doble ensayo ciego’ de la sulpirida en pacientes psicoticos. Minerva Psiquiatrica Argentina, 1, 29–50.Google Scholar
Birley, J. L. T. & Brown, G. W. (1970) Crisis and life changes preceding the onset or relapse of acute schizophrenia: clinical aspects. British Journal of Psychiatry, 116, 327–333.Google Scholar
Bjerkenstedt, L. Harnryd, C. & Sedvall, G. (1979) Effect of sulpiride on monoaminergic mechanisms in psychotic women. Psychopharmacology, 64, 135–139.CrossRefGoogle ScholarPubMed
Blanco, J. M. Sanchez, J. C. Diaz, J. A. & Zubia, B. Z. (1972) Ensayo clinico con Dogmatil y placebo en esquizofrenicos cronicos (Estudio de 89 enfermos, con applicacion de la escala de Harris, Letemendia y Willems). Archivos de Neurobiologia, 35, 3–22.Google Scholar
Borenstein, P. Cujo, P. Champion, C. & Olivenstein, C (1968) Etude d'un nouveau psychotrope: le sulpiride (1403 RD) 1. Méthode et résultats cliniques. Annales Médico-psychologiques, 126, ii, 90–99.Google Scholar
Bratfos, O. & Haug, J. O. (1979) Comparison of sulpiride and chlorpromazine in psychoses. A double-blind multicentre study. Acta Psychiatrica Scandinavica, 60, 1–9.Google Scholar
Brown, G. W. & Birley, J. L. T. (1968) Crisis and life changes and the onset of schizophrenia. Journal of Health and Social Behaviour, 9, 203–214.CrossRefGoogle Scholar
Carranza, J. Vargas, L. & Gomes, J. (1973) A double-blind evaluation of sulpiride, a new antipsychotic compound. Clinical Pharmacology and Therapeutics, 14, 132–133.Google Scholar
Carrère, J. (1968) Étude des effets du sulpiride sur l'état psychique de quarante malades mentaux. Annates Médico-psychologiques, 126, ii 560–574.Google Scholar
Cassano, G. B. Castrogiovanni, P. Conti, L. & Bonollo, L. (1975) Sulpiride versus haloperidol in schizophrenia: a double-blind comparative trial. Current Therapeutic Research, 17, 189–201.Google Scholar
Collard, J. (1969) Le sulpiride, un neuroleptique singulier antiautistique et thymanaleptique. La Semaine des Hõpitaux, 45, 3028–3033.Google Scholar
Dohrenwend, B. S. & Dohrenwend, B. P. (1978) Some issues in research on stressful life events. Journal of Nervous and Mental Disease, 166, 7–15.Google Scholar
Elizur, A. & Davidson, S. (1975) The evaluation of the anti-autistic activity of sulpiride. Current Therapeutic Research, 18, 578–584.Google Scholar
Elliott, P. N. C. Jenner, P. Huzing, G. Marsden, C. D. & Miller, R. (1977) Substituted benzamides as cerebral dopamine antagonists in rodents. Neuropharmacology, 16, 333–342.Google Scholar
Halpern, B. Sircovich, O. & Winnik, H. Z. (1973) A clinical experiment with sulpiride. Israel Annals of Psychiatry and Related Disciplines, 11, 1–10.Google Scholar
Ishimaru, T. Kubo, S. Ishikawa, H. et al (1971) Clinical evaluation of therapeutic effects of sulpiride, a neuroleptic drug, on schizophrenia by double-blind controlled test. Hiroshima Journal of Medical Science, 19, 131–154.Google Scholar
Jenner, P. & Marsden, C. D. (1979) The substituted benzamides—a novel class of dopamine antagonists. Life Sciences, 25, 479–486.Google Scholar
Kebabian, J. W. & Calne, D. B. (1979) Multiple receptors for dopamine. Nature, 277, 93–96.Google Scholar
Meltzer, H. Y. So, R. Miller, R. J. & Fang, V. S. (1979) Comparison of the effects of substituted benzamides and standard neuroleptics on the binding of 3H-spiroperidol in the rat pituitary and striatum with in vivo effects on rat prolactin secretion. Life Sciences, 25, 573–584.Google Scholar
Mielke, D. H. Gallant, D. M. & Kessler, C. (1977a) An evaluation of a unique new antipsychotic agent, sulpiride: effects on serum prolactin and growth hormone levels. American Journal of Psychiatry, 134, 1371–1375.Google Scholar
Mielke, D. H. Gallant, D. M. Roniger, J. J. Kessler, C. & Kessler, L. R. (1977b) Sulpiride: evaluation of antipsychotic activity in schizophrenic patients. Diseases of the Nervous System, 38, 569–571.Google Scholar
Mouren, P. Mayet, J. & Larrieu, A. (1970) Essai clinique d'une molécule nouvelle, le sulpiride, en pratique psychiatrique. La Semaine des Hopitaux, 46, 97–103.Google Scholar
Nishiura, M. (1976) Clinico-pharmacological studies of sulpiride. Current Therapeutic Research, 20, 164–172.Google Scholar
Overall, J. E. & Gorham, D. R. (1962) The Brief Psychiatric Rating Scale. Psychological Reports, 10, 799–812.Google Scholar
Pinto, C. A. C. (1972) O uso do sulpiride em esquizofrenia (Ensaio duplo cego), Boletim de Psiquiatria, 5, 103–142.Google Scholar
Schneider, K. (1959) Clinical Psychopathology, translated by Hamilton, M. W. New York: Grune & Stratton.Google Scholar
Setyonegoro, R. K. & Dipojono, B. (1975) Treatment of unselected Indonesian psychotic patients with Dogmatil. Jiwa Majalah Psikiatri, 8, 1–10.Google Scholar
Simpson, G. M. & Angus, J. W. S. (1970) A rating scale for extrapyramidal side effects. In Drug Induced Extrapyramidal Disorders. Acta Psychiatrica Scandinavica, Supplementum, 212, 11–19.CrossRefGoogle ScholarPubMed
Tanimukai, H. Inui, M. Takahashi, H. & Kaneko, Z. (1973) A double-blind comparison of sulpiride with thioridazine on schizophrenia. Seishin Igaku, 15, 81–91.Google Scholar
Taverna, P. Ghisoni, T. & Poggi, E. (1972) Étude controlée de l'activité antipsychotique du Dogmatil. Psychologic Médicale, 4, 811–818.Google Scholar
Toru, M. Shimazono, Y. Miyasaka, M. Kokubo, T. Mori, Y. & Nasu, T. (1972) A double-blind comparison of sulpiride with chlorpromazine in chronic schizophrenia. Journal of Clinical Pharmacology, 12, 221–229.Google Scholar
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