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A Controlled Trial of Prothipendyl (Tolnate) in Mentally Subnormal Patients

Published online by Cambridge University Press:  29 January 2018

Margaret E. McKenzie  and
Daphne Roswell-Harris
Margaret E. McKenzie
Affiliation:
Leavesden Hospital
Daphne Roswell-Harris
Affiliation:
Leavesden Hospital, Abbots Langley, Watford, Herts
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Extract

The improvement shown by a group of severely subnormal patients after treatment with prothipendyl (Tolnate) was the reason for conducting a double-blind trial to assess the effects of the drug, while attempts were made to control the environment. The preliminary group studied consisted of 35 patients of both sexes, of all ages, who all exhibited pronounced behaviour disorders and presented acute problems in nursing and management. None had responded adequately to the more widely used tranquillizers and sedatives, but all except two patients with superadded depression, responded to prothipendyl in some measure without side effects.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 112 , Issue 482 , January 1966 , pp. 95 - 100
Copyright
Copyright © Royal College of Psychiatrists, 1966 

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