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Controlled Trial of P2647 in Elderly Psychiatric Patients

Published online by Cambridge University Press:  29 January 2018

Alan R. Dabbs  and
Hugh F. Paterson
Alan R. Dabbs
Affiliation:
Oakwood Hospital, Maidstone
Hugh F. Paterson
Affiliation:
Oakwood Hospital, Maidstone
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Extract

Claimed by the manufacturers as pharmacologically unique, benzquinamide (P2647) is structurally related to reserpine, and to a lesser degree, chlorpromazine (1). It has been demonstrated as markedly suppressing conditioned avoidance responses in animals without influencing the release of central amines, e.g. norepinephrine and serotonin. Animal studies have suggested that this drug is the least sedating of the benzoquinolizine derivatives, acts rapidly and is non-toxic at the recommended dosage levels.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 109 , Issue 459 , March 1963 , pp. 300 - 302
Copyright
Copyright © Royal College of Psychiatrists, 1963 

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References

1. Data from Pfizer Ltd., Sandwich, Kent. Google Scholar
2. Feldman, P. E., Psychosomatics, March, 1962, 148–151.Google Scholar
3. Smith, M. E., Amer. J. Psychiat., 1962, 118, 937–938.CrossRefGoogle Scholar
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