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A controlled family study of late-onset non-affective psychosis (late paraphrenia)

Published online by Cambridge University Press:  03 January 2018

R. J. Howard*
Affiliation:
Institute of Psychiatry, London
C. Graham
Affiliation:
The Maudsley Hospital, London
P. Sham
Affiliation:
Institute of Psychiatry, London
J. Dennehey
Affiliation:
Institute of Psychiatry, London
D. J. Castle
Affiliation:
Institute of Psychiatry, London
R. Levy
Affiliation:
Institute of Psychiatry, London
R. Murray
Affiliation:
Institute of Psychiatry, London
*
Section of Old Age Psychiatry. Institute of Psychiatry, Dc Crespigny Park, Camberwell, London SES 8AF. Fax: 0171 701 0167

Abstract

Background

The relationship between those schizophrenia-like conditions that have their onset in late life and early-onset schizophrenia is unclear. Very few family history studies of patients with late-onset psychosis have been reported, and it is not known whether their relatives have an increased risk of psychosis.

Method

Information was collected on the psychiatric morbidity of 269 first-degree relatives of patients with schizophrenia or delusional disorder with an onset after the age of 60 (late paraphrenia), and 272 first-degree relatives of healthy elderly control subjects, using a research diagnostic instrument.

Results

With a narrow age range (15–50 years) at risk, the estimated lifetime risk of schizophrenia was 1.3% in the relatives of both cases and controls. With a wider age range (15–90 years) at risk, estimated lifetime risk of schizophrenia was 2.3% for the relatives of cases, and 2.2% for the relatives of controls. However, depression was significantly more common among the relatives of cases than controls.

Conclusion

Those schizophrenia-like psychoses with onset in late life are not genetically associated with schizophrenia.

Type
Papers
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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References

Almeida, O., Howard, R., Levy, R., et al (1995) Cognitive features of psychotic states arising in late life (late paraphrenia). Psychological Medicine, 25, 685698.CrossRefGoogle ScholarPubMed
Andreascn, N. C., Rice, J. P., Endicott, J., et al (1986) The family history approach to diagnosis. How useful is it? Archives of General Psychiatry, 43, 421429.Google Scholar
Castle, D. J. & Murray, R. M. (1991) The neurodevelopmental basis of sex differences in schizophrenia. Psychological Medicine, 21, 565575.CrossRefGoogle ScholarPubMed
Castle, D. J. & Murray, R. M. & Howard, R. (1992) What do we know about the etiology of late-onset schizophrenia? European Psychiatry, 7, 99108.CrossRefGoogle Scholar
Gorwood, P., Leboyer, M., Jay, M., et al (1995) Gender and age at onset in schizophrenia: impact of family history. American Journal of Psychiatry, 152, 208212.Google ScholarPubMed
Gottesman, I. I. & Shields, J. (1982) Schizophrenia, the Epigenetic Puzzle. Cambridge: Cambridge University Press.Google Scholar
Howard, R., Almedia, O. & Levy, R. (1994) Phenomen-ology. demography and diagnosis in late paraphrenia. Psychological Medicine, 24, 397410.CrossRefGoogle ScholarPubMed
Howard, R., Almedia, O. & Levy, R. et al (1994) Quantitative magnetic resonance imaging volumetry distinguishes delusional disorder from late-onset schizophrenia. British Journal of Psychiatry, 165, 474480.CrossRefGoogle ScholarPubMed
Howard, R., Almedia, O. & Levy, R., Dennehey, J., Lovestone, S., et al (1995) Apolipopro-tein E genotype and late paraphrenia. International Journal of Geriatric Psychiatry, 10, 147150.CrossRefGoogle Scholar
Howard, R., Almedia, O. & Levy, R., Dennehey, J., Lovestone, S., Mallars, J., Patty, R., et al (1995) Magnetic resonance imaging volumetric measurements of the superior temporal gyrus, hippocampus, parahippocampal gyrus, frontal and temporal lobes in late paraphrenia. Psychological Medicine, 25, 495503.CrossRefGoogle ScholarPubMed
Kendtor, K. S., Tsuang, M. T. & Hays, P. (1987) Age at onset in schizophrenia: a familial perspective. Archives of General Psychiatry, 44, 881890.Google Scholar
Kendtor, K. S., Tsuang, M. T. & Hays, P., Karkowski-Shuman, L. & Walsh, D. (1996) Age at onset in schizophrenia and risk of illness in relatives. Results from the Roscommon family study. British Journal of Psychiatry, 169, 213218.Google Scholar
Sham, P. C., Jonas, P., Russall, A., et al (1994) Age at onset, sex and familial psychiatric morbidity in schizophrenia. Report from the Camberwell collaborative psychosis study. British Journal of Psychiatry, 165, 466473.CrossRefGoogle ScholarPubMed
Shimizu, A. & Kurachi, M. (1989) Do women without a family history of schizophrenia have a later onset of schizophrenia ? Japanese Journal of Psychiatry and Neurology, 43, 133136.Google ScholarPubMed
Slater, E. & Cowie, V. (1971) The Genetics of Mental Disorders. Oxford: Oxford University Press Google Scholar
World Health Organization (1992) The ICD-10 Classification of Mental and Behavioural Disorders. Geneva: WHO.Google Scholar
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