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A Controlled Cross-over Study of Trimipramine and Amylobarbitone

Published online by Cambridge University Press:  29 January 2018

J. W. Hunter ,
Susanne Owen ,
Aysel Eksi  and
J. F. Scott
J. W. Hunter
Affiliation:
Late of Psychiatric Unit, Rochford General Hospital
Susanne Owen
Affiliation:
Late of Psychiatric Unit, Rochford General Hospital
Aysel Eksi
Affiliation:
Late of Psychiatric Unit, Rochford General Hospital
J. F. Scott
Affiliation:
Mathematics Division, University of Sussex, Falmer, Brighton, Sussex
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Extract

Chemically, trimipramine has an imino-benzyl nucleus and a side-chain resembling that of methotrimeprazine [5-(3-dimethyl-amino-2-methyl-propyl)-10, 11-dihydrodibenz (b, f,) azepine]. In “double blind” controlled comparisons of trimipramine and imipramine, Salzmann (1965) in 27 hospitalized depressed patients who did not require ECT, found the two drugs not significantly different in effect. Blumenthal and Seppala (1965) obtained similar results. Burns (1965), however, in 44 patients suffering from psychotic depression, found trimipramine to be significantly superior at the 5 per cent. level to imipramine in ratings of recovery from depression, anxiety and insomnia. No difference was found in the latency interval between the drugs.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 113 , Issue 499 , June 1967 , pp. 667 - 670
Copyright
Copyright © Royal College of Psychiatrists, 1967 

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References

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