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Continuing treatment of panic disorder after acute response: randomised, placebo-controlled trial with fluoxetine

Published online by Cambridge University Press:  02 January 2018

David Michelson ,
Mark Pollack ,
R. Bruce Lydiard ,
Roy Tamura ,
Rosalinda Tepner ,
Gary Tollefson  and
The Fluoxetine Panic Disorder Study Group
David Michelson*
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA
Mark Pollack
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA
R. Bruce Lydiard
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA
Roy Tamura
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA
Rosalinda Tepner
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA
Gary Tollefson
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA
*
Dr David Michelson, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 2324, Indianapolis, IN 46285, USA. Tel: (317) 277-6443; Fax: (317) 277-3262
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Abstract

Background

Data concerning appropriate treatment in panic disorder following an initial response to acute therapy are limited.

Aims

To assess the safety and efficacy of continued fluoxetine treatment following successful acute therapy of panic disorder.

Method

Patients who responded to acute fluoxetine treatment were randomised to 24 weeks of continued fluoxetine or placebo.

Results

Fluoxetine responders randomised to continue on their acute-phase fluoxetine dose experienced statistically significant improvement in panic attack frequency and phobia rating scale score over 24 weeks of therapy, while those switched to placebo experienced statistically significant worsening in Hamilton Anxiety (HAM–A), Hamilton Depression (HAM–D) and SCL–90–R rating scores.

Conclusions

Fluoxetine was associated with improved clinical outcomes compared with placebo during continuation therapy.

Type
Papers
Information
The British Journal of Psychiatry , Volume 174 , Issue 3 , March 1999 , pp. 213 - 218
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

Declaration of interest

This study was funded by Eli Lilly and Company. Dr Michelson, Dr Tamura, Dr Tollefson and MsTepner are employees of Eli Lilly and Company. Dr Pollack and Dr Lydiard are paid consultants to Eli Lilly and Company.

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