Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-22T07:38:49.437Z Has data issue: false hasContentIssue false
  • English
  • Français

Concordance by Sex in Sibling Pairs with Schizophrenia is Paternally Inherited

Evidence for a Pseudoautosomal Locus

Published online by Cambridge University Press:  02 January 2018

Timothy J. Crow ,
Lynn E. DeLisi  and
Eve C. Johnstone
Timothy J. Crow
Affiliation:
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow HA1 3UJ
Lynn E. DeLisi
Affiliation:
Department of Psychiatry, State University of New York at StonyBrook, StonyBrook, New York, 11756, USA
Eve C. Johnstone
Affiliation:
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow HA1 3UJ
Get access Rights & Permissions [Opens in a new window]

Abstract

The hypothesis that the gene for schizophrenia is located in the pseudoautosomal region of the sex chromosomes predicts that same-sex concordance will occur in paternally rather than maternally derived pairs. In 120 families that included at least one sibling pair with schizophrenia, affected members were significantly more likely to be of the same sex when there was a history of illness on the paternal than on the maternal side, the difference remaining significant when parent of origin was assessed by three different methods. The finding is as predicted by the pseudoautosomal hypothesis: therefore a search for the gene should be focused on this small (three megabase) region of the genome. The ratio of same to mixed sex pairs in paternally-derived cases (approximately 3:1) suggests the gene is located in the centromeric one-third of the pseudoautosomal region.

Type
Point of View
Information
The British Journal of Psychiatry , Volume 155 , Issue 1 , July 1989 , pp. 92 - 97
Copyright
Copyright © The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Book, J. A. (1953) A genetic and neuropsychiatric investigation of a North Swedish population, with special regard to schizophrenia and mental deficiency. Acta Genetica (Basel), 4, 1–100, and 345–414.Google Scholar
Burgoyne, P. S. (1986) Mammalian X and Y crossover. Nature, 319, 258–259.Google Scholar
Crow, T. J. (1983) Is schizophrenia an infectious disease? Lancet, i, 173–175.Google Scholar
Crow, T. J. (1987) Pseudoautosomal locus for psychosis? Lancet, ii, 1532.Google Scholar
Crow, T. J. (1988) Sex chromosomes and psychosis: the case for a pseudoautosomal locus. British Journal of Psychiatry, 153, 675–683.Google Scholar
Crow, T. J. & Done, D. J. (1986) Age of onset in schizophrenia: a test of the contagion hypothesis. Psychiatry Research, 18, 107–117.Google Scholar
Crow, T. J., DeLisi, L. E. & Johnstone, E. C. (1989) Clues to the nature and location of the psychosis gene: is schizophrenia due to an anomaly of the cerebral dominance gene located in the pseudoautosomal region of the sex chromosomes? In Genetics of Neuropsychiatric Disease, Proceedings of a conference held from 26 to 28 May 1988 at the Wenner-Gren Center, Stockholm (ed. Wetterberg L.). Basingstoke: Macmillan.Google Scholar
DeLisi, L. E., Goldin, L. R., Maxwell, E., et al (1987) Clinical features of illness in siblings with schizophrenia or schizoaffective disorder. Archives of General Psychiatry, 44, 891–896.Google Scholar
Goldin, L. R., DeLisi, L. E. & Gershon, E. S. (1987) Unravelling the relationship between genetic and environmental risk factors in psychiatric disorders. British Journal of Psychiatry, 151, 302–305.Google Scholar
Goodfellow, P., Banting, G., Sheer, D., et al (1983) Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome. Nature, 302, 346–349.Google Scholar
Gottesman, I. I. & Shields, J. (1982) Schizophrenia: The Epigenetic Puzzle. Cambridge: Cambridge University Press.Google Scholar
Kallman, F. J. (1946) The genetic theory of schizophrenia: an analysis of 691 schizophrenic twin index families. American Journal of Psychiatry, 103, 309–322.Google Scholar
Kringlen, E. (1968) Heredity and Environment in the Functional Psychoses: an Epidemiological–Clinical Twin Study. London: Heinemann.Google Scholar
Mott, F. W. (1910) Hereditary aspects of nervous and mental diseases. British Medical Journal, ii, 1013–1020.Google Scholar
Myerson, A. (1925) Inheritance of Mental Disease. Baltimore: Williams & Wilkins.Google Scholar
Penrose, L. S. (1942) Auxiliary genes for determining sex as contributory causes of mental illness. Journal of Mental Science, 88, 308–316.Google Scholar
Penrose, L. S. (1945) Survey of cases of familial mental illness. Mimeographed document prepared for the Division of Psychiatric Research, Ontario Department of Health, abstracted in Digest of Neurology & Psychiatry, 13, 644.Google Scholar
Penrose, L. S. (1968) Critical survey of schizophrenia genetics. In Modern Perspectives in World Psychiatry (ed Howells J. G.) pp 3–19. Edinburgh: Oliver & Boyd.Google Scholar
Rosanoff, A. J., Handy, L. M., Plesset, I. R., et al (1934/35) The etiology of so-called schizophrenic psychoses. American Journal of Psychiatry, 91, 247–286.Google Scholar
Rosenthal, D. (1962) Familial concordance by sex with respect to schizophrenia. Psychological Bulletin, 59, 401–421.Google Scholar
Rouyer, F., Simmler, M-C., Johnsson, C., et al (1986) A gradient of sex linkage in the pseudoautosomal region of the human sex chromosomes. Nature, 319, 291–295.Google Scholar
Schulz, B. (1932) Zur Erbpathologie der Schizophrenie. Zeitschrift fur die Gesammte Neurologie und Psychiatrie, 143, 175–293.Google Scholar
Slater, E. T. O. (1953a) Psychotic and Neurotic Illness in Twins. London: HMSO.Google Scholar
Slater, E. T. O. (1953b) Sex-linked recessives in mental illness? Acta Genetica et Statistica Medica, 4, 273–280.Google Scholar
Slater, E. T. O. (1958) The monogenic theory of schizophrenia. Acta Genetica (Basel), 8, 50–56.Google Scholar
Sturt, E. & Shur, E. (1985) Sex concordance for schizophrenia in proband-relative pairs. British Journal of Psychiatry, 147, 44–47.Google Scholar
Suarez, B. K. & van Eerdewegh, P. (1984) A comparison of three affected sib-pair scoring methods to detect HLA-linked disease susceptibility genes. American Journal of Medical Genetics, 18, 135–146.Google Scholar
Tsuang, M. T. (1967) A study of pairs of siblings both hospitalised for mental disorder. British Journal of Psychiatry, 113, 283–300.Google Scholar
von Zehnder, M. (1941) Uber Krankheitsbild und Krankheitsverlauf bei schizophrenen Geschwistern. Monatschrift fur Psychiatrie und Neurologie, 103, 231–277.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.