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Concordance by Sex in Sibling Pairs with Schizophrenia is Paternally Inherited

Evidence for a Pseudoautosomal Locus

Published online by Cambridge University Press:  02 January 2018

Timothy J. Crow ,
Lynn E. DeLisi  and
Eve C. Johnstone
Timothy J. Crow
Affiliation:
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow HA1 3UJ
Lynn E. DeLisi
Affiliation:
Department of Psychiatry, State University of New York at StonyBrook, StonyBrook, New York, 11756, USA
Eve C. Johnstone
Affiliation:
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow HA1 3UJ
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Abstract

The hypothesis that the gene for schizophrenia is located in the pseudoautosomal region of the sex chromosomes predicts that same-sex concordance will occur in paternally rather than maternally derived pairs. In 120 families that included at least one sibling pair with schizophrenia, affected members were significantly more likely to be of the same sex when there was a history of illness on the paternal than on the maternal side, the difference remaining significant when parent of origin was assessed by three different methods. The finding is as predicted by the pseudoautosomal hypothesis: therefore a search for the gene should be focused on this small (three megabase) region of the genome. The ratio of same to mixed sex pairs in paternally-derived cases (approximately 3:1) suggests the gene is located in the centromeric one-third of the pseudoautosomal region.

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The British Journal of Psychiatry , Volume 155 , Issue 1 , July 1989 , pp. 92 - 97
Copyright
Copyright © The Royal College of Psychiatrists 

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