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Computerised Tomography in Newly Diagnosed Schizophrenia and Schizophreniform Disorder

A Controlled Blind Study

Published online by Cambridge University Press:  02 January 2018

Pia Rubin ,
Agnete Karle ,
Ralf Hemmingsen ,
Ulla Noring ,
Susanne Møller-Madsen ,
Charlotte Hertel  and
Uffe Juul Povlsen
Pia Rubin*
Affiliation:
Department of Psychiatry
Agnete Karle
Affiliation:
Department of Radiology, Section of Neuroradiology
Ralf Hemmingsen
Affiliation:
Department of Psychiatry
Ulla Noring
Affiliation:
Department of Psychiatry, Bispebjerg Hospital, University of Copenhagen
Susanne Møller-Madsen
Affiliation:
Department of Psychiatry, Frederiksberg Hospital, University of Copenhagen
Charlotte Hertel
Affiliation:
Department of Psychiatry, Rigshospitalet, University of Copenhagen
Uffe Juul Povlsen
Affiliation:
Department of Psychiatry, Kommunehospitalet, University of Copenhagen
*
∗Department of Psychiatry E, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark
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Abstract

Patients with newly diagnosed schizophrenia (n = 27) or schizophreniform disorder (n = 22) and 24 healthy volunteers were investigated by CT scan, the investigators being blind to subject status. The patients had never received medication or had been treated only briefly with neuroleptics. The patients had significantly smaller brain volume and brain length than the controls. The patients had greater sulcal enlargement in the case of both Sylvian and interhemispheric fissures and surface sulci in the frontal and parietal regions. The sulcal enlargement was more pronounced in male patients and on the left hemisphere. The study revealed no enlargement of the lateral ventricles and only a trend towards enlargement of the third ventricle in the patients. The findings were not explained by substance abuse or level of education.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 163 , Issue 5 , November 1993 , pp. 604 - 612
Copyright
Copyright © Royal College of Psychiatrists, 1993 

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References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM-III-R). Washington, DC: APA.Google Scholar
Andreasen, N. C., Nasrallah, H. A., Dunn, V., et al (1986) Structural abnormalities in the frontal system in schizophrenia. Archives of General Psychiatry, 43, 136–144.Google Scholar
Andreasen, N. C., Ehrhardt, J. C., Swayze, V. W., et al (1990) Magnetic resonance imaging of the brain in schizophrenia. Archives of General Psychiatry, 47, 35–44.Google Scholar
Benes, F., Sunderland, P., Jones, B. D., et al (1982) Normal ventricles in young schizophrenics. British Journal of Psychiatry; 141, 90–93.Google Scholar
Bruton, C. D., Crow, T. J., Frith, C. D., et al (1990) Schizophrenia and the brain: a prospective cliniconeuropathological study. Psychological Medicine, 20, 285–304.Google Scholar
Cannon, T. D., Mednick, S. A. & Parnas, J. (1989) Genetic and perinatal determinants of structural brain deficits in schizophrenia. Archives of General Psychiatry, 46, 883–889.Google Scholar
Crichton-Browne, J. (1879) On the weight of the brain and its component parts in the insane. Brain, 2, 42–67.CrossRefGoogle Scholar
Crow, T. J. (1990) Temporal lobe asymmetries as the key to the etiology of schizophrenia. Schizophrenia Bulletin, 16, 433–443.Google Scholar
Crow, T. J., Ball, J., Bloom, S. R., et al (1989) Schizophrenia as an anomaly of development of cerebral asymmetry. Archives of General Psychiatry, 46, 1145–1150.Google Scholar
Crow, T. J., Brown, R., Burton, C. J., et al (1992) Loss of sylvian fissure asymmetry in schizophrenia: findings in the runwell 2 series of brains. Schizophrenia Research, 6, 152–153.CrossRefGoogle Scholar
De Lisi, L. E., Hoff, L. A., Schwartz, J. E., et al (1991) Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biological Psychiatry, 29, 159–175.Google Scholar
Done, D. J., Johnstone, E. C., Frith, C. D., et al (1991) Complications of pregnancy and delivery in relation to psychosis in adult life: data from the British perinatal mortality survey sample. British Medical Journal, 302, 1576–1580.Google Scholar
Falkai, P., Bogerts, B., Greve, B., et al (1992) Reduced Sylvianfissure and planum temporale asymmetry in schizophrenia. Evidence for disturbed left hemisphere neurodevelopment? Schizophrenia Research, 6, 152.Google Scholar
Heckers, S., Heinsen, H., Heinsen, Y., et al (1991) Cortex, white matter and basal ganglia in schizophrenia: a volumetric postmortem study. Biological Psychiatry, 29, 556–566.Google Scholar
Illowsky, B. P., Juliano, D. M., Bicellow, L. B., et al (1988) Stability of CT scan findings in schizophrenia: results of an 8 year follow-up study. Journal of Neurology, Neurosurgery and Psychiatry, 51, 209–213.Google Scholar
Johnstone, E. C., Crow, T. J., Frith, C. D., et al (1976) Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet, 30, 924–926.Google Scholar
Nasrallah, H. A., Kuperman, S., Hamra, B. J., et al (1983) Clinical differences between schizophrenic patients with and without large cerebral ventricles. Clinical Psychiatry, 44, 407–409.Google Scholar
Nasrallah, H. A., Olson, S. C., McCalley—Whitters, M., et al (1986) Cerebral ventricular enlargement in schizophrenia. Archives of General Psychiatry, 43, 157–159.Google Scholar
Nyback, H., Wiesel, F. A., Berggren, B. M., et al (1982) Computed tomography of the brain in patients with acute psychosis and in healthy volunteers. Acta Psychiatrica Scandinavica, 65, 403–414.CrossRefGoogle ScholarPubMed
Owens, D. G. C., Johnstone, E. C., Crow, T. J., et al (1985) Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations. Psychological Medicine, 15, 27–41.Google Scholar
Pakkenberg, B. (1987) Post-mortem study of chronic schizophrenic brains. British Journal of Psychiatry, 151, 744–752.Google Scholar
Pearlson, G. D., Kim, W. S., Kubos, K. L., et al (1989) Ventricle-brain ratio, computed tomographic density and brain area in 50 schizophrenics. Archives of General Psychiatry, 46, 690–697.Google Scholar
Pfefferbaum, A., Zipursky, R. B., Lim, K. O. (1988) Computed tomographic evidence for generalized sulcal and ventricular enlargement in schizophrenia. Archives of General Psychiatry, 45, 633–640.CrossRefGoogle ScholarPubMed
Rubin, P., Holm, S., Friberg, L., et al (1991) Altered modulation of prefrontal and subcortical brain activity in newly diagnosed schizophrenia and schizophreniform disorder: a regional cerebral blood flow study. Archives of General Psychiatry, 48, 987–995.CrossRefGoogle ScholarPubMed
Schulz, S. C., Koller, M. M., Kishore, P. R., et al (1983) Ventricular enlargement in teenage patients with schizophrenia spectrum disorder. American Journal of Psychiatry, 140, 1592–1595.Google ScholarPubMed
Schwarzkopf, S. B., Nasrallah, H. A., Olson, S. C., et al (1991) Family history and brain morphology in schizophrenia: an M RI study. Psychiatry Research: Neuroimaging, 40, 49–60.CrossRefGoogle Scholar
Scottish Schizophrenia Research Group, Macdonald, H. L. & Best, J. J. K. (1989) The Scottish first episode schizophrenia study: computerised brain scans in patients and controls. British Journal of Psychiatry, 154, 492–498.CrossRefGoogle ScholarPubMed
Shelton, R. C. & Weinberger, D. R. (1987) Brain morphology in schizophrenia. In Psychopharmacology: the Third Generation of Progress (ed. Meltzer, H. Y.), pp. 773–781. New York: Raven Press.Google Scholar
Sponheim, S. R., Iacono, W. G. & Beiser, M. (1991) Stability of ventricular size after the onset of psychosis in schizophrenia. Psychiatry Research: Neuroimaging, 40, 21–29.Google Scholar
Suddath, R. L., Casanova, M. F., Goldberg, T. E., et al (1989) Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. American Journal of Psychiatry, 146, 464–472.Google Scholar
Suddath, R. L., Christison, G. W., Torrey, E. F., et al (1990) Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New England Journal of Medicine, 322, 789–794.Google Scholar
Turner, S. W., Toone, B. K. & Brett-Jones, J. R. (1986) Computerized tomographic scan changes in early schizophrenia: preliminary findings. Psychological Medicine, 16, 219–225.Google Scholar
Vita, A., Sacchetti, E., Valvassori, G., et al (1988) Brain morphology in schizophrenia: a 2- to 5-year CT scan follow-up study. Acta Psychiatrica Scandinavica, 78, 618–621.CrossRefGoogle ScholarPubMed
Weinberger, D. R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44, 660–669.Google Scholar
Weinberger, D. R., DeLisi, L. E., Perman, G. P., et al (1982) Computed tomography in schizophreniform disorder and other psychiatric disorders. Archives of General Psychiatry, 39, 778–783.CrossRefGoogle Scholar
World Health Organization (1992) SCAN: Schedule for Clinical Assessment in Neuropsychiatry. Geneva: WHO.Google Scholar
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