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Comparison of the Effect of Imipramine and Desipramine on Some Symptoms of Depressive Illness

Published online by Cambridge University Press:  29 January 2018

Griffith Edwards
Griffith Edwards*
Affiliation:
Maudsley Hospital, S.E.5
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Extract

The possibility that desipramine might prove to be a rapidly acting antidepressant was first raised by laboratory studies. In 1959 desipramine was isolated as a metabolite of imipramine (Hermann et al., 1959; Hermann and Pulver, 1960), and a series of papers then followed (Brodie et al., 1961; Gillette et al., 1961; Sulser et al., 1962) in which it was shown that reserpine-induced inactivity in the rat can be more rapidly reversed by desipramine than by imipramine. This was referred to (Gillette et al., 1961) as an experimental demonstration of the relative rapidity of the “antidepressant” action of the two drugs. Other experimental reports should however warn against incautious interpretation of laboratory findings. Garattini et al. (1962) showed that desipramine is not responsible for all the actions of imipramine: in mice, leptazol convulsions are inhibited by the latter but not by the former drug. Dingell et al. (1964) were able to show considerable species differences in the rate at which imipramine is converted to desipramine and in the rate at which desipramine is then destroyed. Their paper also emphasizes the paucity of information on the metabolism of imipramine in human subjects.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 478 , September 1965 , pp. 889 - 897
Copyright
Copyright © Royal College of Psychiatrists, 1965 

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References

Azima, H., Silver, A., and Arthurs, D. (1962). Canad. med. Ass. J., 87, 1224–1228.Google Scholar
Ban, T. A., and Lehmann, H. E. (1962). Ibid., 86, 1030–1031.Google Scholar
Bobon, J., and Goffioul, F. (1962). Acta neurol. psychiat. Belg., 62, 359–373.Google Scholar
Brodie, B. B., Bickel, M. H., and Sulser, F. (1961). Med. exp. (Basel), 5, 454–458.CrossRefGoogle Scholar
Brodie, B., Dick, P., Kielholz, P., Poeldinoer, W., and Theobald, W. (1961). Psychopharmacologia (Berl.), 2, 467–474.CrossRefGoogle Scholar
Cmyral, K., and Hofmann, G. (1963). Wien. med. Wschr., 113, 933–935.Google Scholar
Di Mascio, A., Heninoer, G., and Klerman, G. L. (1964). Psychopharmacologia (Berl.), 5, 361–371.Google Scholar
Dingell, J. V., Sulser, F., and Gillette, J. R. (1964). J. Pharmacol, exp. Ther., 143, 14–22.Google Scholar
Garattini, S., Giachetti, A., Jori, A., Pieri, L., and Valzelli, L. (1962). J. Pharmacy and Pharmacol., 14, 509–514.CrossRefGoogle Scholar
Gillette, J. R., Dingell, J. V., Sulser, F., Kuntzman, R., and Brodie, B. B. (1961). Experientia (Basel), 17, 417–418.Google Scholar
Herrmann, B., and Pulver, R. (1960). Arch. int. Pharmacodyn., 126, 454–469.Google Scholar
Hermann, N. B., Schindler, W., and Pulver, R. (1959). Med. exp. (Basel), 1, 381–385.Google Scholar
Hollister, L. E., Overall, J. E., Johnson, M., Katz, G., Kimbell, I., and Honingfeld, G. (1963). J. new Drugs, 3, 161–166.Google Scholar
Kline, N. S., Simpson, G., and Brodie, B. B. (1962). Int. J. Neuropharmacol., 1, 55–60.CrossRefGoogle Scholar
Mann, A. (1962). Canad. med. Ass. J., 86, 495–598.Google Scholar
Mann, A. M., and Heseltine, G. F. D. (1963). Ibid., 88, 1102–1107.Google Scholar
Meduna, L. J., Abood, L. G., and Brel, J. H. (1961). J. Neuropsychiat., 2, 232–237.Google Scholar
Oltman, J. E., and Friedman, S. (1962). Amer.J. Psychiat. 119, 370–371.Google Scholar
Sulser, F., Watts, J., and Brodie, B. B. (1962). Ann. N.T. Acad. Sci., 96, 279–288.Google Scholar
Wilson, I. C., Gambill, J. M., and Sandifer, M. G. (1964). Psychosomatics, 5, 88–91.Google Scholar
Wilson, I. C., Gambill, J. M., Vernon, J. T., Guin, T., and Sandifer, M. G. (1963). J. Neuropsychiat., 4, 331–337.Google Scholar
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