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A Comparison of Nortriptyline and Amitriptyline in Depression

Published online by Cambridge University Press:  29 January 2018

John T. Rose ,
M. R. Leahy ,
Ian C. A. Martin  and
T. T. Westhead
John T. Rose
Affiliation:
Walton Hospital, Liverpool
M. R. Leahy
Affiliation:
St. James's Hospital, Leeds
Ian C. A. Martin
Affiliation:
St. James's Hospital, Leeds
T. T. Westhead
Affiliation:
Walton Hospital, Liverpool
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Extract

Nortriptyline (Allegron, Aventyl) is the demethylated metabolite of amitriptyline. Preliminary trials by Bennett (1962), Oltman et al. (1963) and Leahy et al. (1964) indicated that it might be an effective anti-depressant. Forrest et al. (1964) found that it compared favourably with amitriptyline, a widely used anti-depressant of established efficacy. This investigation also compares nortriptyline with amitriptyline.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 480 , November 1965 , pp. 1101 - 1103
Copyright
Copyright © Royal College of Psychiatrists, 1965 

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References

Bennett, I. F. (1962). J. nerv. ment. Dis., 135, 58.CrossRefGoogle Scholar
Forrest, A. D., Affleck, J. W. McL., Gibb, I. A., and Priest, R. G. (1964). Scot. med. J., 9, 341.Google Scholar
Hamilton, M. (1960). J. Neurol. Neurosurg. Psychiat., 23, 56.Google Scholar
Leahy, M. R., and Rose, J. T. (1964). Am. J. Psychiat., 121, 72.Google Scholar
Oltman, J. E., and Friedman, S. (1963). Am. J. Psychiat., 119, 988.CrossRefGoogle Scholar
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