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A Comparative Trial of a New Antidepressant, Fluoxetine

Published online by Cambridge University Press:  02 January 2018

S. Levine ,
R. Deo  and
K. Mahadevan
S. Levine*
Affiliation:
Oldham and District General Hospital
R. Deo
Affiliation:
Oldham and District General Hospital
K. Mahadevan
Affiliation:
Bolton and District General Hospital, Farnworth, Bolton
*
∗Oldham and District General Hospital, Rochdale Road, Oldham OL1 2JH
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Abstract

This clinical trial of a new antidepressant, fluoxetine, shows it to be as effective as a standard tricyclic drug, imipramine. It is effective as a single daily dose and is free of any significant side-effects. It is less sedative and appears to cause fewer problems of weight increase. The three scales used to assess efficacy showed a very positive correlation.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 150 , Issue 5 , May 1987 , pp. 653 - 655
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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References

Asberg, M., Thoren, P., Traskman, L., Bertilsson, L. & Ringberger, W. (1976) Serotonin depression: a biochemical subgroup within the affective disorders. Science, 191, 478–481.Google Scholar
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology Neurosurgery and Psychiatry, 23, 56–62.Google Scholar
Kearns, N. P., Cruickshank, C. A., McGuioan, K. J., Riley, S. A., Shaw, S. P. & Snaith, R. P. (1982) A comparison of depression rating scales. British Journal of Psychiatry, 141, 45–49.Google Scholar
Lembercer, L., Bergstrom, R. F., Wolen, R. L., Farid, N. A., Enas, G. G. & Arnoff, G. R. (1985) Fluoxetine: clinical pharmacology and physiological disposition. Journal of Clinical Psychiatry, 46, 3, 14–19.Google Scholar
Levine, S. (1975) A controlled comparison of Maprotiline (Ludiomil) with imipramine avoiding observer bias. Journal of International Medical Resesearch, 3 (Suppl. 2), 75.Google Scholar
Montgomery, S. A. & Asberg, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382–389.Google Scholar
Pilowsky, I. & Boulton, D. M. (1970) Development of a questionnaire-based decision rule for classifying depressed patients. British Journal of Psychiatry, 117, 685–688.CrossRefGoogle Scholar
Pilowsky, I. & Spalding, D. (1972) A method for measuring depression: validity studies on a depression questionnaire. British Journal of Psychiatry, 121, 411–416.Google Scholar
Pilowsky, I., Levine, S. & Boulton, D. M. (1969) The classification of depression by numerical taxonomy. British Journal of Psychiatry, 115, 937–945.Google Scholar
Prusoff, B. A., Klerman, G. L. & Paykel, E. S. (1972) Concordance between clinical assessments and patients' self-report in depression. Archives of General Psychiatry, 26, 546.Google Scholar
Spitzer, R., Endicott, J. & Robins, E. (1975) Research Diagnostic Criteria. New York: New York State Psychiatric Institute.Google Scholar
Van Praag, H. M. (1977) Indoleamines in depression. In Handbook of Studies in Depression (ed. G. Burrows) Amsterdam: Elsevier.Google Scholar
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