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A Comparative Investigation of Desipramine and Nortriptyline in the Treatment of Depression

Published online by Cambridge University Press:  29 January 2018

Ijaz Haider
Ijaz Haider*
Affiliation:
Department of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Morningside Park, Edinburgh 10
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Extract

Most of the investigators to date have been comparing desipramine with imipramine, and little work has been published on comparative studies of the demethylated compounds of imipramine and amitriptyline, i.e. desipramine and nortriptyline. Arieff (1966) conducted a clinical study, but did not find any difference between the two drugs, and stated “However, the improvement was never as striking or as rapid as when imipramine or amitriptyline was effective.” Steward and Mitchell (1966) in a double-blind controlled study also found no difference between the two drugs.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 114 , Issue 515 , October 1968 , pp. 1293 - 1294
Copyright
Copyright © Royal College of Psychiatrists, 1968 

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References

Arieff, A. J. (1966). “Desipramine and nortriptyline in mental depression.” Amer. J. Psychiat., 122, 1291.CrossRefGoogle ScholarPubMed
Medical Research Council (1965). “Clinical trial of the treatment of depressive illness.” Brit. med. J., i, 881.Google Scholar
Steward, A. J., and Mitchell, P. H. (1966). “A comparative trial of desipramine and nortriptyline.” IV World Congress of Psychiatry, Madrid, Sept. 1966. Excerpta Medica, Int. Congr. Series No. 117, p. 401.Google Scholar
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