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Comparative Effects of Lithium and Chlorpromazine in the Treatment of Acute Manic States

Published online by Cambridge University Press:  29 January 2018

Gordon Johnson ,
Samuel Gershon ,
Eugene I. Burdock ,
Arthur Floyd  and
Leon Hekimian
Gordon Johnson
Affiliation:
Neuropsychopharmacology Research Unit
Samuel Gershon
Affiliation:
Neuropsychopharmacology Research Unit
Eugene I. Burdock
Affiliation:
Neuropsychopharmacology Research Unit, Department of Psychiatry, New York University Medical Center, 550 First Avenue, New York, U.S.A.
Arthur Floyd
Affiliation:
Neuropsychopharmacology Research Unit, Department of Psychiatry, New York University Medical Center, 550 First Avenue, New York, U.S.A.
Leon Hekimian
Affiliation:
Neuropsychopharmacology Research Unit, Department of Psychiatry, New York University Medical Center, 550 First Avenue, New York, U.S.A.
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Extract

There are well over 50 published reports since 1949 on the use of lithium salts in psychiatric disorders, most of them in the decade since 1960. Considering only those studies reported in acute manic states, it is difficult to arrive at a reliable assessment of the specific therapeutic effect of lithium because quantitative evaluations were seldom employed, so that comparisons of outcome have to be based on statements of degree of improvement which are subject to varying interpretations. Furthermore most of the studies were not adequately controlled, and the diagnostic criteria used were not always clear.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 119 , Issue 550 , September 1971 , pp. 267 - 276
Copyright
Copyright © The Royal College of Psychiatrists, 1971 

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