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Collaborative Strategies in the Molecular Genetics of the Major Psychoses

Published online by Cambridge University Press:  02 January 2018

Marion Leboyer  and
Peter McGuffin
Marion Leboyer
Affiliation:
Unite des Recherches de Genetique Epidemiologique, INSERM, Bois de Boulogne, Paris, France
Peter McGuffin*
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff
*
∗Correspondence
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Extract

Most authorities now agree that a genetic contribution is the best established aetiological factor in manic-depressive illness (McGuffin & Katz, 1989) and schizophrenia (Gottesman & Shields, 1982). In both cases the size of the genetic contribution is substantial, as reflected in estimates of broad heritability (the proportion of total phenotypic variance accounted for by genes) of 60–80%. However, the evidence in favour of a genetic contribution from family, twin and adoption studies tells us that we are dealing with complex conditions which do not have simple Mendelian modes of transmission and in which environmental influences almost certainly play a part. The main debate about mode of transmission has centred upon whether it is entirely polygenic (i.e. dependent upon the action of many different genes, each of small effect) or whether for each of the major psychoses there is a gene of major effect.

Type
Molecular Biology Symposium
Information
The British Journal of Psychiatry , Volume 158 , Issue 5 , May 1991 , pp. 605 - 610
Copyright
Copyright © Royal College of Psychiatrists, 1991 

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