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Clovoxamine and Doxepin in Major Depressive Disorder: A Double-Blind Controlled Trial

Published online by Cambridge University Press:  29 January 2018

G. J. Lodge  and
Hugh L. Freeman
G. J. Lodge
Affiliation:
Roundway Hospital, Devizes, Wilts. SN10 5DS
Hugh L. Freeman*
Affiliation:
Hope Hospital, Salford, M6 8HD
*
∗Correspondence
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Abstract

Clovoxamine, an inhibitor of neuronal uptake of both serotin and noradrenaline, was compared with doxepin in depressed patients over four weeks. Antidepressant efficacy was comparable for both drugs, but clovoxamine might have a special degree of efficacy for patients with more severe depressive illnesses.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 148 , Issue 6 , June 1986 , pp. 718 - 721
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

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References

Bradford, L. D., Tulp, M. T. M. & Schipper, J. (1985) Biochemical effects in rats after long-term treatment with fluvoxamine and clovoxamine: postsynaptic changes. Society of Neurosciences Abstracts, 11, 774.Google Scholar
Calanca, A., Freeman, H. L., Hole, G. & Wakelin, J. S. (1983) Clovoxamine: a new non-tricyclic anti-depressant—a European multi-centre initial study. Comprehensive Psychiatry, 24, 179–182.Google Scholar
Classen, V., Boschman, T. A. C., Dhasmana, K. M., Hillen, F. C., Vaatstra, W. J. & Zwagemakers, J. M. A. (1978) Pharmacology of clovoxamine, a new non-tricyclic anti depressant. Arnzneimittel-Forschung/Drug Research, 28, 1756–1766.Google Scholar
Freeman, H. L., Wakelin, J. S., Calanca, A. & Hole, G. (1982) Initial clinical evaluation of a new non-tricyclic anti-depressant. In Typical and Atypical Anti-depressants, (eds Costa, E. & Racogni, G.) New York: Raven Press.Google Scholar
Gelenberg, A. J., Woieuk, J. D. & Newell, C. (1985) a double-blind comparison of clovoxamine and amitriptyline in the treatment of depressed out-patients. Journal of Clinical Psychopharmacology, 5, 30–34.Google Scholar
Richelson, E. & Pfenning, M. (1984) Blockade by antidepressants and related compounds of biogenic amine uptake into rat brain synaptosomes: most antidepressants selectively block norepinephrine uptake. European Journal of Pharmacology. 104, 277–286.Google Scholar
Robinson, J. F. & Doogan, D. P. (1982) a placebo-controlled study of the cardiovascular effects of fluvoxamine and clovoxamine in human volunteers. British Journal of Clinical Pharmacology, 14, 277–286.Google Scholar
Wright, J. H., McNeely, J. D., Moore, D. P. & Hurst, H. E. (1981) Early clinical trial of clovoxamine: a new anti-depressant. Current Therapeutic Research, 29, 148–15.Google Scholar
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