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Clinical Assessment and Performance Tasks in Depression: a Comparison of Amitriptyline and Trazodone

Published online by Cambridge University Press:  02 January 2018

W. A. Botros ,
S. I. Ankier ,
R. G. Priest ,
I. C. McManus ,
J. Steinert  and
Z. Y. Samir
W. A. Botros
Affiliation:
St Mary's Hospital Medical School
S. I. Ankier
Affiliation:
Roussel Laboratories Ltd, Charterhouse Clinical Research Unit Ltd
R. G. Priest*
Affiliation:
Academic Department of Psychiatry
I. C. McManus
Affiliation:
St Mary's Hospital Medical School
J. Steinert
Affiliation:
Hammersmith Hospital
Z. Y. Samir
Affiliation:
St Mary's Hospital Medical School
*
∗St Mary's Hospital Medical School, Praed Street, London W2 1NY
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Abstract

Depression, anxiety and psychomotor performance were assessed in 20 depressed patients during double-blind treatment with amitriptyline or trazodone. There was no difference in onset of antidepressant or anxiolytic action. No decrement or improvement on computerised tasks was found. Dry mouth was significantly more frequent and severe with amitriptyline.

Type
Papers
Information
The British Journal of Psychiatry , Volume 155 , Issue 4 , October 1989 , pp. 479 - 482
Copyright
Copyright © Royal College of Psychiatrists 1989 

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References

Al-Yassiri, M. M., Ankier, S. I. & Bridges, P. K. (1981) Trazodone – a new antidepressant. Life Science, 28, 2449–2458.Google Scholar
Al-Yassiri, M. M., Ankier, S. I. & Bridges, P. K. (1983) A double blind comparison of the efficacy and safety of trazodone and imipramine in endogenous depression. Journal of Affective Disorders, 5, 333–340.Google Scholar
Bedford, A., Foulds, G. A. & Sheffield, B. F. (1976) A new personal disturbance scale (DSSI/SAD). British Journal of Social and Clinical Psychology, 15, 387–394.Google Scholar
Brogden, R. N., Heel, R. C., Speight, T. M., et al (1981) Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs, 21, 401–476.Google Scholar
Carney, M. W. P., Roth, M. & Garside, R. F. (1965) The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry, 111, 659–674.Google Scholar
Ellis, B. W., Johns, M. W., Lancaster, R., et al (1981) The St Mary's Hospital sleep questionnaire: a study of reliability. Sleep, 4, 93–97.Google Scholar
Gershon, S. & Newton, R. (1980) Lack of anticholinergic side-effects with a new antidepressant – trazodone. Journal of Clinical Psychiatry, 41, 100–104.Google Scholar
Hamilton, M. (1967) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278–296.Google Scholar
McManus, I. C., Ankier, S. I., Norfolk, J., et al (1983) Effects on psychological performance of the benzodiazepine, loprazolam, alone and with alcohol. British Journal of Clinical Pharmacology, 16, 291–300.Google Scholar
Montgomery, S. A. & Åsberg, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382–389.Google Scholar
Montgomery, I., Oswald, I., Morgen, K., et al (1983) Trazodone enhances sleep in subjective quality but not in objective duration. British Journal of Clinical Pharmacology, 16, 139–144.Google Scholar
Van de Merwe, T., Silverstone, T., Ankier, S. I., et al (1984) A double blind, non-crossover, placebo controlled, between group comparison of trazodone and amitriptyline on cardiovascular function in major depressive disorder. Psychopathology, 17, (Suppl. 2), 64–76.Google Scholar
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