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Chromosomal Aberrations in a Patient with Severe Psychopathology

Published online by Cambridge University Press:  02 January 2018

Gunnar Akner
Affiliation:
Karolinska Institute, Novum F60, Huddinge University Hospital, 141 86, Huddinge, Sweden
Karl-Henrik Gustavson
Affiliation:
Academic Hospital, University of Uppsala, 751 85 Uppsala, Sweden
Eva Håkansson
Affiliation:
Academic Hospital, University of Uppsala, 751 85 Uppsala, Sweden
Jan Sääf
Affiliation:
Karolinska Institute, St Goran's Hospital, Stockholm, Sweden
Hans Kiessling
Affiliation:
151 85 Södertälje, Sweden
Arthur Yuwiler
Affiliation:
T-85, Veterans Administration Medical Center, Brentwood, Los Angeles CA 90073, USA
Lennart Wetterberg*
Affiliation:
Karolinska Institute, St Goran's Hospital, S-11281 Stockholm, Sweden
*
Correspondence

Abstract

The case of a female patient showing aggressive, compulsive, destructive behaviour, ritualistic faecal smearing, and hyperactivity is presented. The behaviour is long standing, therapy-resistant, and its aetiology is unknown, although it is seemingly associated with chromosomal abnormalities secondary to abnormal plasma factors.

Type
Brief Reports
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Benson, L., Gustavson, K.-H., Rastad, J., et al (1988) Cytogenetical investigations in patients with primary hyper-para-thyroidism and multiple endocrine neoplasia type 1. Hereditas, 108, 227229.Google Scholar
Buckton, K. E. & Evans, H. J. (1973) Methods for the Analysis of Human Chromosomal Aberrations. WHO: Geneva.Google Scholar
Dellarco, U. L., Mavournin, K.-H. & Waters, M. D. (1985) An evaluation of current testing approaches for detection of chemically induced aneuploidy. In Aneuploidy (eds Dellarco, V. L., Voytek, P. E. & Hollaender, A.), pp. 445454. New York: Plenum Press.Google Scholar
Emerit, I. (1982) Chromosome breakage factors: origin and possible significance. Progress in Mutation Research, 4, 6174.Google Scholar
Fisher, T. J. W., Otten, B. J., Monnens, L. A. H., et al (1982) Low renin, low aldosterone hypertension and abnormal Cortisol metabolism in a 19 month-old-child. Hormone Research, 16, 107114.Google Scholar
Gustavson, K.-H., Jansson, R. & Öberg, K. (1983) Chromosomal breakage in multiple endocrine adenomatosis (types I and II). Clinical Genetics, 23, 143149.Google Scholar
Hoffmann, G. R. (1985) Etiology of aneuploidy: a synopsis. In Aneuploidy (eds Dellarco, V. L., Voytek, P. E. & Hollaender, A.). New York: Plenum Press.Google Scholar
Högstedt, B. (1984) Micronuclei in lymphocytes with preserved cytoplasma method for assessment of cytogenetic damage in man. Mutation Research, 130, 6372.Google Scholar
Nordenson, I. (1979) Clinical and experimental studies of chromosomal aberrations in cultured leucocytes. Umeå University Medical Dissertations, New Series, No. 43.Google Scholar
Pichot, P. (1984) The French approach to psychiatric classification. British Journal of Psychiatry, 144, 113118.Google Scholar
Reeder, M. M. & Felson, B. (1975) Diffuse or widespread increased density, hyperostosis, or thickness of the calvarium. Thick skull syndrome. Gamut, A-10. In Gamuts in Radiology. Comprehensive Lists of Roentgen Differential Diagnoses. Cincinnati: Audiovisual Radiology of Cincinnati, Inc.Google Scholar
Rojanasakul, A., Gustavson, K.-H., Lithell, H., et al (1985) Tetraploidy in two sisters with the polycystic ovary syndrome. Clinical Genetics, 27, 167174.Google Scholar
Wetterberg, L., Akner, G., Kiessling, H., et al (1988) Clastogenic factors and abnormal plasma fractions in a female patient with severe aggressiveness. British Journal of Psychiatry, 152, 579.Google Scholar
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