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Childhood Attentional Dysfunctions Predict Social Deficits in Unaffected Adults at Risk for Schizophrenia

Published online by Cambridge University Press:  06 August 2018

Barbara A. Cornblatt ,
Mark F. Lenzenweger ,
Robert H. Dworkin  and
L. Erlenmeyer-Kimling
Barbara A. Cornblatt*
Affiliation:
Mt. Sinai School of Medicine, Elmhurst Hospital Center, 79-01 Broadway, Elmhurst, New York 11373
Mark F. Lenzenweger
Affiliation:
Department of Human Development, Cornell University, Ithaca, New York
Robert H. Dworkin
Affiliation:
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York
L. Erlenmeyer-Kimling
Affiliation:
Columbia University College of Physicians and Surgeons, New York, New York
*
Correspondence
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Extract

Converging lines of evidence suggest that attentional dysfunctions are indicators of a biological susceptibility to some forms of schizophrenia. More specifically, following the criteria outlined by Holzman (1983), impaired attention can be considered a potential biological marker because of the: (a) well replicated association between schizophrenia and attentional dysfunctions in patients, both when in episode and in remission (Nuechterlein & Dawson, 1984); (b) evidence that attentional problems can be detected in unaffected first-degree adult relatives of schizophrenic patients (Wood & Cook, 1979; Keefe et al, 1989, Steinhauer et al, 1991) (c) reports from a number of high-risk studies that attentional deficits pre-date clinical symptoms by many years (Rutschmann et al, 1977; Nuechterlein, 1983; Cornblatt & Erlenmeyer-Kimling, 1985; Mirsky et al, 1986; Erlenmeyer-Kimling & Cornblatt, 1987b; Mirsky, 1988) and (4) preliminary results suggesting that attention per se is genetically transmitted (Cornblatt et al, 1988).

Type
Risk factors
Information
The British Journal of Psychiatry , Volume 161 , Issue S18: Onset and Course of Schizophrenic Disorders: Dynamic Interactions between Relevant Factors , October 1992 , pp. 59 - 64
Copyright
Copyright © The Royal College of Psychiatrists 

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References

American Psychiatric Association (1987). Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM-III-R). Washington DC: APA.Google Scholar
Bellack, A. S., Morrison, R. L., Wixted, J. T., et al (1990) An analysis of social competence in schizophrenia. British Journal of Psychiatry, 156, 809–818.CrossRefGoogle ScholarPubMed
Cattell, R. B. (1966) The Scree test for the number of factors. Multivariate Behavioral Research, 1, 245–276.Google Scholar
Cornblatt, B. & Erlenmeyer-Kimling, L. (1985) Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. Journal of Abnormal Psychology, 94, 470–486.Google Scholar
Cornblatt, B., Risch, N., Faris, G., et al (1988) The Continuous Performance Test, Identical Pairs Version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Research, 26, 223–238.CrossRefGoogle ScholarPubMed
Cornblatt, B., Winters, L. & Erlenmeyer-Kimling, L. (1989) Attentional markers of schizophrenia: evidence from the New York High-Risk Study. In Schizophrenia: Scientific Progress (eds S. C. Schulz & C. A. Tamminga), pp. 83–92. New York: Oxford University Press.Google Scholar
Endicott, J. & Spitzer, R. L. (1978) A diagnostic interview: The Schedule for Affective Disorders and Schizophrenia (SADS). Archives of General Psychiatry, 35, 837–844.CrossRefGoogle Scholar
Erlenmeyer-Kimling, L. & Cornblatt, B. (1978) Attentional measures in a study of children at high-risk for schizophrenia. Journal of Psychiatric Research, 14, 93–98.CrossRefGoogle Scholar
Erlenmeyer-Kimling, L. & Cornblatt, B. (1987a) The New York high-risk project: A follow-up report. Schizophrenia Bulletin, 13, 451–463.Google Scholar
Erlenmeyer-Kimling, L. & Cornblatt, B. (1987b) High-risk research in schizophrenia: a summary of what has been learned. Journal of Psychiatric Research, 21, 401–411.Google Scholar
Holzman, P. S. (1983) Smooth pursuit eye movements in psychopathology. Schizophrenia Bulletin, 9, 33–36.CrossRefGoogle ScholarPubMed
Iacono, W. G. (1988) Eye movement abnormalities in schizophrenia and affective disorders. In Neuropsychology of Eye Movements (eds C. S. Johnston & F. J. Pirozzolo), pp. 115–145. NJ: Lawrence Erlbaum Associates.Google Scholar
Keefe, R. S. E., Mohs, R. C., Siever, L. J., et al (1989) Relations among eye tracking, CPT and backward masking deficits in schizophrenic patients and their relatives. Biological Psychiatry, 25, 102.Google Scholar
Knight, R. A. (1984) Converging models of cognitive deficit in schizophrenia. In Nebraska Symposium on Motivation, 1983: Theories of Schizophrenia and Psychosis (eds W. D. Spaulding & J. K. Cole), pp. 93–156. Lincoln: University of Nebraska Press.Google Scholar
Knight, R. A., A., R., Elliott, D. S., Roff, J. D., et al (1986) Concurrent and predictive validity of components of disordered thinking in schizophrenia. Schizophrenia Bulletin, 12, 427–446.CrossRefGoogle ScholarPubMed
Loranger, A. W., Susman, V. L., Oldham, J. M., et al (1987) The personality disorder examination: a preliminary report. Journal of Personality Disorders, 1, 1–13.Google Scholar
Matthysse, S. & Holzman, P. S. (1987) Genetic latent structure models: implication for research on schizophrenia. Psychological Medicine, 17, 271–274.CrossRefGoogle ScholarPubMed
Mirsky, A. (1988) The Israeli high-risk study. In Relatives at Risk for Mental Disorder (eds D. L. Dunner, E. S. Gershon & J. E. Barrett), pp. 279–297. New York: Raven Press.Google Scholar
Mirsky, A., Duncan, C., Silberman, E., et al (1986) Early neuropsychological and other behavioral predictors of later psychotic disorders. In Biological Psychiatry (eds C. Shagass, G. Simpson, W. Bridger, et al), pp. 1118–1120. New York: Elsevier.Google Scholar
Morrison, R. L. & Bellack, A. S. (1987) Social functioning of schizophrenic patients: clinical and research issues. Schizophrenia Bulletin, 13, 715–725.CrossRefGoogle ScholarPubMed
Nuechterlein, K. H. (1983) Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. Journal of Abnormal Psychology, 92, 4–28.Google Scholar
Nuechterlein, K. H. & Dawson, M. E. (1984) Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophrenia Bulletin, 10, 160–203.CrossRefGoogle ScholarPubMed
Rutschmann, J., Cornblatt, B. & Erlenmeyer-Kimling, L. (1977) Sustained attention in children at risk for schizophrenia. Archives of General Psych iatry, 34, 571–575.Google Scholar
Siever, L. J. (1985) Biological markers in schizotypal personality disorder. Schizophrenia Bulletin, 11, 564–575.Google Scholar
Spitzer, R. L. & Endicott, J. (1977) Schedule for Affective Disorders and Schizophrenia Lifetime Version (SADS-L) (3rd edn). New York: New York State Psychiatric Institute, Biometrics Unit.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders (3rd edn). New York: New York State Psychiatric Institute, Biometrics Unit.Google Scholar
Squires-Wheeler, E., Skodol, A. E., Bassett, A., et al (1989) DSM-III-R Schizotypal personality traits in offspring of schizophrenia disorder, affective disorder, and normal control parents. Journal of Psychiatric Research, 23, 229–239.CrossRefGoogle ScholarPubMed
Steinhauer, S. R., Zubin, J., Condray, R., et al (1991) Electrophysiological and behavioral signs of attentional disturbance in schizophrenics and their siblings. In Schizophrenia Research: Advances in Neuropsychiatry and Psychopharmacology, Vol. 1 (eds Tamminga, C. A. & Schulz, S. C.), pp. 169–178. New York: Raven Press.Google Scholar
Wechsler, D. (1949) The Wechsler Intelligence Scale for Children. New York: The Psychological Corporation.Google Scholar
Weissberg, R., Ruff, H. A. & Lawson, K. R. (1990) The usefulness of reaction time tasks in studying attention and organization of behavior in young children. Journal of Developmental & Behavioral Pediatrics, 11, 59–64.Google Scholar
Winer, B. J. (1971) Statistical Principles in Experimental Designs (2nd edn). New York: McGraw-Hill.Google Scholar
Wood, R. L. & Cook, M. (1979) Attentional deficit in the siblings of schizophrenics. Psychological Medicine, 9, 465–467.Google Scholar
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