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Changes of Plasma Concentrations of Interleukin-1α and Interleukin-6 with Neuroleptic Treatment for Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Hai-Min Xu ,
Jun Wei  and
Gwynneth P. Hemmings
Hai-Min Xu
Affiliation:
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain
Jun Wei*
Affiliation:
Institute of Biological Psychiatry, Schizophrenia Association of Great Britain
Gwynneth P. Hemmings
Affiliation:
Schizophrenia Association of Great Britain
*
∗Institute of Biological Psychiatry, Wellcome Building, Deiniol Road, Bangor, Gwynedd LL57 2UW
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Abstract

A significant difference of plasma interleukin (IL)-1α concentration was found between schizophrenic patients taking neuroleptic drugs (n = 38) and those not taking them (n = 14; P < 0.02); Kruskal-Wallis analysis revealed a significant difference of plasma IL-6 concentration among the patients taking neuroleptic drugs, those not taking them, and healthy control subjects (H = 7.1, d.f. = 2, P < 0.05); also, there was a significant difference of plasma IL-6 concentration between the patients taking neuroleptic drugs (n = 32) and those not taking them (n = 13; P < 0.01). No significant differences were found between the three groups in the concentrations of IL-1β, IL-2 and tumour necrosis factor(TNF)-α. The present results suggest that neuroleptic treatment may change IL-1α and IL-6 production in schizophrenic patients.

Type
Short Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 2 , February 1994 , pp. 251 - 253
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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References

Andrews, R. C. R. (1990) Unification of the findings in schizophrenia by reference to the effects of gestational zinc deficiency. Medical Hypotheses, 31, 141–153.10.1016/0306-9877(90)90010-CGoogle Scholar
Arai, K., Lee, F., Miyajima, A., et al (1990) Cytokines: coordinators of immune and inflammatory responses. Annual Reviews of Biochemistry, 59, 783–836.10.1146/annurev.bi.59.070190.004031Google Scholar
Banks, W. A. & Kastin, A. J. (1991) Blood to brain transport of interleukin links the immune and central nervous system. Life Sciences, 48, 117–121.10.1016/0024-3205(91)90385-OCrossRefGoogle Scholar
Hama, T., Kushima, Y., Miyamoto, M., et al (1991) Interleukin-6 improves the survival of mesencephalic catecholaminergic and septal cholinergic neurons from postnatal, two-week-old rats in cultures. Neuroscience, 40, 445–452.10.1016/0306-4522(91)90132-8CrossRefGoogle ScholarPubMed
Selmaj, K. W., Farooq, M., Norton, W. T., et al (1990) Proliferation of astrocytes in vitro in response to cytokines: a primary role for tumour necrosis factor. Journal of Immunology, 144, 129–135.CrossRefGoogle Scholar
Shintani, F., Kanba, S., Maruo, N., et al (1991) Serum interleukin-6 in schizophrenic patients. Life Sciences, 49, 661–664.10.1016/0024-3205(91)90112-OCrossRefGoogle ScholarPubMed
Slater, E. & Roth, M. (1972) Schizophrenia. In Mayer-Gross Slater and Roth's Clinical Psychiatry (3rd edn), pp. 237–341. London: Bailliere, Tindall & Cassell.Google Scholar
Smith, R. S. (1991) Is schizophrenia caused by excessive production of interleukin-2 and interleukin-2 receptors by gastrointestinal lymphocytes? Medical Hypotheses, 34, 225–229.10.1016/0306-9877(91)90215-KGoogle Scholar
Van Snick, J. (1990) Interleukin-6: an overview. Annual Reviews of Immunology, 8, 253–278.10.1146/annurev.iy.08.040190.001345Google Scholar
Villemain, F., Chatenoud, L., Guillibert, E., et al (1987) Decreased production of interleukin 2 in schizophrenia. Annals of the New York Academy of Sciences, 496, 669–675.10.1111/j.1749-6632.1987.tb35828.xCrossRefGoogle ScholarPubMed
Wei, J., Ramchand, C. N. & Hemmings, G. P. (1992a) Studies on concentrations of NA and HVA and activity of DBH in the serum from schizophrenic patients, first-degree relatives and normal subjects. Schizophrenia Research, 8, 103–110.10.1016/0920-9964(92)90025-ZCrossRefGoogle ScholarPubMed
Wei, J., Xu, H-M., Davies, J. I., et al (1992b) Increase of plasma IL-6 concentration with age in healthy subjects. Life Sciences, 51, 1953–1956.10.1016/0024-3205(92)90112-3CrossRefGoogle ScholarPubMed
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