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Changes in Schizophrenic Psychopathology and Ward Behaviour as a Function of Phenothiazine Treatment

Published online by Cambridge University Press:  29 January 2018

Solomon C. Goldberg ,
Gerald L. Klerman  and
Jonathan O. Cole
Solomon C. Goldberg
Affiliation:
Psychopharmacology Service Center, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
Gerald L. Klerman
Affiliation:
Massachusetts Mental Health Center, and Harvard Medical School. Address: 74 Fenwood Road, Boston 15, Massachusetts
Jonathan O. Cole
Affiliation:
Psychopharmacology Service Center, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
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Extract

Although the efficacy of chlorpromazine and other phenothiazine derivatives in the treatment of schizophrenic psychotic reactions has been established for almost a decade, there remain differences of opinion regarding which symptoms and behaviours are affected favourably by psychopharmacologic treatment. By and large, the phenothiazines have been characterized as “ataractics” or “tranquillizers”, the implication being that their predominant action is to calm excited patients by relieving the patient's anxiety or other forms of psychic distress. However, clinical experience increasingly asserts that the phenothiazines influence many manifestations of schizophrenic patients other than anxiety and excitement, including symptoms such as incoherent thought and apathy.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 111 , Issue 471 , February 1965 , pp. 120 - 133
Copyright
Copyright © Royal College of Psychiatrists, 1965 

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