Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-22T15:59:43.616Z Has data issue: false hasContentIssue false
  • English
  • Français

Changes in Auditory P3 Event-related Potential in Schizophrenia and Depression

Published online by Cambridge University Press:  02 January 2018

D. H. R. Blackwood ,
L. J. Whalley ,
J. E. Christie ,
I. M. Blackburn ,
D. M. St Clair  and
A. McInnes
D. H. R. Blackwood*
Affiliation:
University of Edinburgh
I. M. Blackburn
Affiliation:
MRC Brain Metabolism Unit, Royal Edinburgh Hospital
D. M. St Clair
Affiliation:
University of Edinburgh
A. McInnes
Affiliation:
EEG Department, Western General Hospital, Edinburgh
*
∗Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF
Get access Rights & Permissions [Opens in a new window]

Abstract

Event-related potentials during a two-tone discrimination task were recorded in 24 schizophrenic patients, 16 depressed patients and 59 control subjects. Recordings were made when patients were medication-free. Fourteen schizophrenic and 13 depressed patients were retested at 1 and 4 weeks after the start of treatment, and 13 schizophrenic patients were also tested between 6 and 24 months after the initial recordings. In the schizophrenic group, the P3 latency was significantly prolonged compared with that in the control and the depressed groups, and remained unchanged both after 4 weeks treatment with therapeutic doses of neuroleptic drugs and at long-term follow-up. In the depressed group, the P3 latency did not differ from that of controls. P3 amplitude by contrast was reduced in both the acutely depressed and schizophrenic groups and following treatment became normal in the depressed group but remained reduced in the schizophrenic group. It is suggested that a prolonged P3 latency and reduced P3 amplitude indicate an impairment of auditory information processing in some patients with schizophrenia which is independent of the presence of acute psychotic symptoms and is not influenced by neuroleptic medication.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 150 , Issue 2 , February 1987 , pp. 154 - 160
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adler, L. E., Pachtman, E., Franks, R. D., Pecevich, M., Waldo, M. C. & Freedman, R. (1982) Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia. Biological Psychiatry, 17, 639–654.Google Scholar
Baribeau-Braun, J., Picton, T. W. & Goselin, J. Y. (1983) Schizophrenia: a neurophysiological evaluation of abnormal information processing. Science, 219, 874–876.Google Scholar
Bartfai, A., Levander, S. E. & Sedvall, G. (1983) Smooth pursuit eye movements, clinical symptoms, CSF metabolites, and skin conductance habituation in schizophrenic patients. Biological Psychiatry, 18, 971–985.Google Scholar
Brecher, M. & Begleiter, H. (1983) Event-related brain potentials to high-incentive stimuli in unmedicated schizophrenic patients. Biological Psychiatry, 18, 661–674.Google Scholar
Ford, J. M., Roth, W. T., Mohs, R. C., Hopkins, W. F. & Kopell, B. S. (1979) Event-related potentials recorded from young and old adults during a memory retireval task. Electroencephalography and Clinical Neurophysiology, 47, 450–459.Google Scholar
Gruzelier, J. H. & Venables, P. H. (1972) Skin conductance orienting activity in a heterogeneous sample of schizophrenics. Journal of Nervous and Mental Disease, 155, 277–287.CrossRefGoogle Scholar
Hamilton, M. (1960) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278–296.Google Scholar
Hillyard, S. A. & Kutas, M. (1983) Electrophysiology of cognitive processing. Annual Review of Psychology, 34, 33–61.Google Scholar
Holzman, P. S., Proctor, L. R. & Hughes, D. W. (1973) Eye-tracking patterns in schizophrenia. Science, 181, 179–181.Google Scholar
Kutas, M., McCarthy, G. & Donchin, E. (1977) Augmenting mental chronometry: the P300 as a measure of stimúlus evaluation time. Science, 197, 792–795.Google Scholar
Lader, M. (1977) Effects of psychotropic drugs on auditory evoked potentials in man. In Auditory Evoked Potentials in Man. Psychopharmacological Correlates of EPS (ed. J. E. Desmedt). Basel: Karger.Google Scholar
Levit, R. A., Sutton, S. & Zubin, J. (1973) Evoked potential correlates of information processing in psychiatric patients. Psychological Medicine, 3, 487–494.Google Scholar
Nie, N. H., Hull, C. H. & Jenkins, J. G. (1970) Statistical Package for the Social Sciences. New York: McGraw Hill.Google Scholar
Overall, J. E. & Gorham, D. R. (1962) The Brief Psychiatric Rating Scale. Psychological Reports, 10, 799–812.Google Scholar
Pass, H. L., Klorman, R., Salzman, L. F., Klein, R. H. & Kaskey, G. B. (1980) The late positive component of the evoked response in acute schizophrenics during a test of sustained attention. Biological Psychiatry, 15, 9–20.Google Scholar
Pfefferbaum, A., Horvath, T. B., Roth, W. T., Tinklenberg, J. R. & Kopell, B. S. (1980) Auditory brain stem and cortical evoked potentials in schizophrenia. Biological Psychiatry, 15, 209–223.Google Scholar
Pfefferbaum, A., Wenegrat, B. G., Ford, J. M., Roth, W. T. & Kopell, B. S. (1984) Clinical application of the P3 component of event-related potentials. II. dementia, depression and schizophrenia. Electroencephalography and Clinical Neurophysiology, 59, 104–124.Google Scholar
Roth, W. T. (1983) A comparison of P300 and skin conductance response. In Tutorials in ERP Research (eds A. W. K. Gaillard & W. Ritter). Amsterdam: North Holland.Google Scholar
Roth, W. T. & Cannon, E. H. (1972) Some features of the auditory evoked response in schizophrenics. Archives of General Psychiatry, 27, 466–471.CrossRefGoogle ScholarPubMed
Roth, W. T., Pfefferbaum, A., Horvath, T. B., Berger, P. A. & Kopell, B. S. (1980) P3 reduction in auditory evoked potentials of schizophrenics.Google Scholar
Roth, W. T., Pfefferbaum, A., Horvath, T. B., Berger, P. A., Kelly, A. F., Berger, P. A. & Kopell, B. S. (1981) Auditory event-related potentials in schizophrenia and depression. Psychiatric Research, 4, 199–212.Google Scholar
Shagass, C., Straumanis, J. J., Roemer, R. A. & Amadeo, M. (1977) Evoked potentials of schizophrenics in several sensory modalities. Biological Psychiatry, 12, 221–235.Google Scholar
Shagass, C., Roemer, R. A., Straumanis, J. J. & Amadeo, M. (1978) Evoked potential correlates of psychosis. Biological Psychiatry, 13, 163–184.Google Scholar
Siegel, C., Waldo, M., Mizner, G., Adler, L. E. & Freedman, R. (1984) Deficits in sensory gating in schizophrenic patients and their relatives. Archives of General Psychiatry, 41, 607–612.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978) Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry, 35, 773–782.Google Scholar
Squires, N. K., Donchin, E., Squires, K. C. & Grossberg, S. (1977) Bisensory stimulation. Inferring decision related processes from the P300 component. Journal of Experimental Psychology, 3,199–315.Google ScholarPubMed
St Clair, D. M., Blackwood, D. H. R. & Christie, J. E. (1985) P3 and other long latency auditory evoked potentials in Alzheimer's dementia and alcoholic Korsakoff syndrome. British Journal of Psychiatry, 147, 702–706.Google Scholar
Steinhauer, S. & Zubin, J. (1982) Vulnerability to schizophrenia: Information processing in the pupil and event-related potential. In Biological Markers in Psychiatry and Neurology (eds E. Usdin & I. Hanin). London: Pergamon Press.Google Scholar
Verleger, R. & Cohen, R. (1978) Effects of certainty, modality shift and guess outcome on evoked potentials and reaction times in chronic schizophrenics. Psychological Medicine, 8, 81–93.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. London: Cambridge University Press.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.