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Cerebral blood flow alterations specific to auditory verbal hallucinations in schizophrenia

Published online by Cambridge University Press:  02 January 2018

Chuanjun Zhuo ,
Jiajia Zhu ,
Wen Qin ,
Hongru Qu ,
Xiaolei Ma  and
Chunshui Yu
Chuanjun Zhuo
Affiliation:
Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, and Department of Psychiatry Functional Neuroimaging Laboratory, Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin
Jiajia Zhu
Affiliation:
Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, China
Wen Qin
Affiliation:
Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, China
Hongru Qu
Affiliation:
Department of Psychiatry, Tianjin Anning Hospital, Tianjin, China
Xiaolei Ma
Affiliation:
Department of Psychiatry, Tianjin Anning Hospital, Tianjin, China
Chunshui Yu
Affiliation:
Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China
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Abstract

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Background

Auditory verbal hallucinations (AVHs) have been associated with deficits in auditory and speech-related networks. However, the resting-state cerebral blood flow (CBF) alterations specific to AVHs in schizophrenia remain unknown.

Aims

To explore AVH-related CBF alterations in individuals with schizophrenia.

Method

In total, 35 individuals with schizophrenia with AVHs, 41 individuals with schizophrenia without AVHs and 50 controls underwent arterial spin labelling magnetic resonance imaging. The CBF differences were voxel-wise compared across the three groups.

Results

We found AVH-specific CBF increase in the right superior temporal gyrus and caudate, and AVH-specific CBF decrease in the bilateral occipital and left parietal cortices. We also observed consistent CBF changes in both schizophrenia subgroups (i.e. those with and without AVHs) including decreased CBF in the bilateral occipital regions, the left lateral prefrontal and insular cortices, and the right anterior cingulate cortex and increased CBF in the bilateral lateral temporal regions and putamen, the left middle cingulate cortex and the right thalamus.

Conclusions

The AVH-specific CBF increases in the auditory and striatal areas and CBF reductions in the visual and parietal areas suggest that there exists a CBF redistribution associated with AVHs.

Type
Papers
Information
The British Journal of Psychiatry , Volume 210 , Issue 3 , March 2017 , pp. 209 - 215
Copyright
Copyright © Royal College of Psychiatrists, 2017 

Footnotes

*

These authors contributed equally to this work.

Declaration of interest

None.

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