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Central D2 Receptors and Negative Symptoms of Schizophrenia

Published online by Cambridge University Press:  02 January 2018

J. L. Martinot ,
M. L. Paillère-Martinot ,
C. Loc'h ,
Y. Lecrubier ,
M. H. Dao-Castellana ,
F. Aubin ,
J. F. Allilaire ,
B. Mazoyer ,
B. Mazière  and
A. Syrota
J. L. Martinot*
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
M. L. Paillère-Martinot
Affiliation:
Service de psychopathologie de l'enfant et de l'adolescent
C. Loc'h
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
Y. Lecrubier
Affiliation:
INSERM U302, hôpital de la Salpêtrière, Paris
M. H. Dao-Castellana
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
F. Aubin
Affiliation:
INSERM U302, hôpital de la Salpêtrière, Paris
J. F. Allilaire
Affiliation:
Service de psychiatrie, INSERM U302
B. Mazoyer
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
B. Mazière
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
A. Syrota
Affiliation:
INSERM U 334 and Service Hospitalier, Frédéric Joliot, Orsay
*
∗INSERM U334, Service Hospitalier Frédéric Joliot, 4 place du général Leclerc, 91406 Orsay, France
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Abstract

Most in vivo studies of striatal D2 receptor (SD2R) density with positron emission tomography in schizophrenia have attempted to relate this variable to the diagnosis of the illness. In the present study, a relationship between SD2R and clinical dimensions of this psychosis was searched for in a highly selected group of young negative schizophrenics (8 drug-naïve and 2 drug-free). The SD2R density index measured in vivo using 76Br-bromolisuride and PET correlated negatively (r = 0.80, P < 0.01) with a psychomotor dimension of schizophrenia involving blunted affect and alogia. The mean SD2R index of the patients did not differ from that of age-matched control subjects. Therefore, this behavioural dimension accounts for the variance of the SD2R, suggesting that the striatal dopamine system modulates symptoms such as flattened affect and alogia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 1 , January 1994 , pp. 27 - 34
Copyright
Copyright © The Royal College of Psychiatrists 

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References

Alexander, G. E. & Delong, M. R. (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357–381.Google Scholar
Alheid, G. F., Heimer, L. & Switzer, R. C. III (1990) Basal ganglia. In The Human Nervous System (ed. Paxinos, G.), pp. 483–582. San Diego: Academic Press.Google Scholar
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised). Washington, DC: APA Press.Google Scholar
Andreasen, N. C. (1987) L'utilisation de la SANS et de la SAPS. Psychiatry & Psychobiology, 2, 412.Google Scholar
Andreasen, N. C. (1989) Neural mechanisms of negative symptoms. British Journal of Psychiatry, 155 (suppl. 7), 93–98.Google Scholar
Andreasen, N. C., Alpert, M. & Martz, M. J. (1981) Acoustic analysis. Archives of General Psychiatry, 38, 281–285.CrossRefGoogle ScholarPubMed
Andreasen, N. C., & Olsen, S. (1982) Negative vs positive schizophrenia: definition and validation. Archives of General Psychiatry, 39, 789–794.CrossRefGoogle Scholar
Andreasen, N. C., Carson, R., Diksic, M., et al (1988) Workshop on schizophrenia, PET, and D2 receptors in the human neo-striatum. Schizophrenia Bulletin, 14, 471–484.Google Scholar
Arndt, S., Alliger, R. J. & Andreasen, N. C. (1991) The distinction of positive and negative symptoms: the failure of a two-dimensional model. British Journal of Psychiatry, 158, 317–322.Google Scholar
Aubin, F., Lecrubier, Y. & Boyer, P. (1991) Principal component analysis of the SANS. Biological Psychiatry, 29, 393S.Google Scholar
Baron, J. C., Mazière, B., Loch, C., et al (1986) Loss of striatal 76 Br-bromospiperone binding sites demonstrated by positron tomography in progressive supranuclear palsy. Journal of Cerebral Blood Flow and Metabolism, 6, 131–136.CrossRefGoogle Scholar
Bleuler, E. (1950) Translated as Dementia Praecox, or the Group of Schizophrenias by Zinkin, J. New-York: International Universities Press.Google Scholar
Blin, J., Baron, J. C., Bonnet, A. M., et al (1989) Striatal dopamine D2 receptors in tardive dyskinesia: PET study. Journal of Neurology, Neurosurgery, and Psychiatry, 52, 1248–1252.CrossRefGoogle ScholarPubMed
BMDP (1985) BMDP Statistical Software Manual. Berkeley: University of California Press.Google Scholar
Boyer, P. & Lecrubier, Y. (1987) Fiche descriptive et traduction française de la SAPS. Psychiatry & Psychobiology, 2, 425–437.CrossRefGoogle Scholar
Breier, A., Wolkowitz, O. M., Doran, A. R., et al (1987) Neuroleptic responsivity of negative and positive symptoms in schizophrenia. American Journal of Psychiatry, 144, 1549–1555.Google Scholar
Carpenter, W. T., Bartko, J. J., Strauss, J. S., et al (1978) Signs and symptoms as predictors of outcome: a report from the International Pilot Study of schizophrenia. American Journal of Psychiatry, 135, 940–945.Google Scholar
Carpenter, W. T., Heinrichs, D. W. & Wagman, A. M. (1988) Deficit and non deficit forms of schizophrenia: the concept. American Journal of Psychiatry, 145, 578–583.Google Scholar
Crow, T. J. (1980) Molecular pathology of schizophrenia: more than one disease process? British Medical Journal, 280, 66–68.CrossRefGoogle ScholarPubMed
Crow, T. J. (1985) The two-syndrome concept: origins and current status. Schizophrenia Bulletin, 234, 471–486.Google Scholar
Delforge, J., Loch, C., Hantraye, P., et al (1991) Kinetic analysis of central [76 Br] Bromolisuride binding to dopamine D2 receptors studied by PET. Journal of Cerebral Blood Flow and Metabolism, 11, 914–925.Google Scholar
Donoghue, J. P. & Herkenham, M. (1986) Neostriatal projections from individual cortical fields conform to histochemically distinct striatal compartments in the rat. Brain Research, 365, 397–403.Google Scholar
Farde, L., Wiesel, F. A., Stone-Elander, S., et al (1990) D2 dopamine receptors in neuroleptic-naïve schizophrenic patients: a positron emission tomography study with [11C] raclopride. Archives of General Psychiatry, 47, 213–219.Google Scholar
Grace, A. A. (1991) Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience, 41, 1–24.Google Scholar
Harris, A. & Metcalfe, M. (1956) Inappropriate affect. Journal of Neurology and Psychiatry, 19, 308–313.Google Scholar
Johnstone, E. C., Owens, D. G. C., Frith, C. D., et al (1986) The relative stability of positive and negative features in chronic schizophrenia. British Journal of Psychiatry, 150, 60–64.Google Scholar
Knight, R. A., Roff, J. D., Barnett, J., et al (1979) Concurrent and predictive validity of thought disorder and affectivity: a 22 year follow-up of acute schizophrenics. Journal of Abnormal Psychology, 88, 1–12.Google Scholar
Konig, P., Benzer, M. K. & Fritzsche, H. (1991) SPECT technique for visualization of cerebral dopamine D2 receptors. American Journal of Psychiatry, 148, 1607–1608.Google Scholar
Lecrubier, Y. & Boyer, P. (1987) Fiche descriptive et traduction française de la SANS. Psychiatry & Psychobiology, 2, 414–420.Google Scholar
Lee, T., Seeman, P., Tourtelotte, W. W., et al (1978) Binding of H-neuroleptics and H-apomorphine in schizophrenic brains. Nature, 274, 897–900.Google Scholar
Liddle, P. F. (1987) The symptoms of chronic schizophrenia: a re-examination of the positive-negative dichotomy. British Journal of Psychiatry, 151, 145–151.Google Scholar
Liddle, P. F. & Morris, D. L. (1991) Schizophrenic syndromes and frontal lobe performance. British Journal of Psychiatry, 158, 340–345.Google Scholar
Liddle, P. F., Friston, K. J., Frith, C. D., et al (1992) Patterns of cerebral blood flow in schizophrenia. British Journal of Psychiatry, 160, 179–186.Google Scholar
Mackay, A. V. P., Bird, O., Bird, E. D., et al (1980) Dopamine receptors and schizophrenia: drug effect or illness? Lancet, ii, 915–916.Google Scholar
Martinot, J. L., Peron-Magnan, P., Huret, J. D., et al (1990) Striatal D2 dopaminergic receptors assessed with positron emission tomography and 76Br-Bromospiperone in untreated schizophrenic patients. American Journal of Psychiatry, 147, 44–50.Google Scholar
Martinot, J. L., Paillere-Martinot, M. L., Loch, C., et al (1991) The estimated density of D2 striatal receptors in schizophrenia: a study with positron emission tomography and 76Br-Bromolisuride. British Journal of Psychiatry, 158, 346–350.CrossRefGoogle ScholarPubMed
Mayer, M., Alpert, M., Stasny, P., et al (1985) Multiple contributions to clinical presentation of flat affect in schizophrenia. Schizophrenia Bulletin, 11, 420–426.Google Scholar
Maziêre, B., Loch, C., Stulsaft, O., et al (1990) PET imaging of D2 receptors in the living baboon or humain brain in normal and pathological conditions using 76Br-Bromolisuride. In Neuropsychopharmacology (eds W. E. Bunney, H. Hippins, G. Laakman, et al), pp. 409–417. Heidelberg: Springer-Verlag.Google Scholar
McGlashan, T. & Fenton, W. S. (1992) The positive-negative distinction in schizophrenia: review of natural history validators. Archives of General Psychiatry, 49, 63–72.Google Scholar
Moal, M. L. & Simon, H. (1991) Meso-corticolimbic dopaminergic network: functional and regulatory roles. Physiological Review, 71, 155–234.Google Scholar
Montgomery, S. A. & Åsberg, M. (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry, 134, 382–389.Google Scholar
Moscarelli, M., Maffei, C., Cesana, B. M., et al (1987) An international perspective on assessment of negative and positive symptoms in schizophrenia. American Journal of Psychiatry, 144, 1595–1598.Google Scholar
Mundt, C. H., Kasper, S. & Huerkamp, M. (1989) The diagnostic specificity of negative symptoms and psychopathological context. British Journal of Psychiatry, 155 (suppl. 7), 32–36.Google Scholar
Munk-Jorgensen, P. & Mortensen, P. B. (1989) Schizophrenia: a 13-year follow up. Acta Psychiatrica Scandinavica, 79, 391–399.Google Scholar
Nelson, H. E., Pantelis, C., Carruthers, K., et al (1990) Cognitive functioning and symptomatology in chronic schizophrenia. Psychological Medecine, 20, 357–365.CrossRefGoogle ScholarPubMed
Owen, F., Cross, A. J., Crow, T. J., et al (1978) Increased dopamine receptor sensitivity in schizophrenia. Lancet, ii, 223–226.Google Scholar
Pantelis, C., Barnes, T. R. E. & Nelson, H. E. (1992) Is the concept of frontal–subcortical dementia relevant to schizophrenia? British Journal of Psychiatry, 160, 442–460.CrossRefGoogle ScholarPubMed
Peralta, V., de Leon, J. & Cuesta, M. (1992) Are there more than two syndromes in schizophrenia? A critique of the positive–negative dichotomy. British Journal of Psychiatry, 161, 335–343.Google Scholar
Praag, H. M. Van, Asnis, G. M., Kahn, R. S., et al (1990) Monoamines and abnormal behaviour: a multi-aminergic perspective. British Journal of Psychiatry, 157, 723–734.Google Scholar
Ring, N., Tantam, D., Montague, L., et al (1991) Negative symptoms in chronic schizophrenia: relationship to duration of illness. British Journal of Psychiatry, 159, 495–499.Google Scholar
Rodgers, D., Lees, A. J., Smith, E., et al (1987) Bradyphrenia in Parkinson's disease and psychomotor retardation in depressive illness: an experimental study. Brain, 110, 761–776.Google Scholar
Seeman, P., Niznik, H. B. & Hong-Chang, G. (1990) Elevation of dopamine D2 receptors in schizophrenia is underestimated by radioactive raclopride. Archives of General Psychiatry, 47, 1170–1172.CrossRefGoogle ScholarPubMed
Strauss, J., Bartko, J. & Carpenter, W. (1973) Classification by cluster analysis. The International Pilot Study of Schizophrenia, pp. 336–359. Geneva: World Health Organization.Google Scholar
Volkow, N. D., Fowler, J. S., Wolf, A. P., et al (1990) Effect of chronic cocaine abuse on postsynaptic dopamine receptors. American Journal of Psychiatry, 147, 719–724.Google Scholar
Weinberger, D. R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44, 660–669.CrossRefGoogle ScholarPubMed
Widlöcher, D. J. & Ghozlan, A. (1989) The measurement of retardation in depression. In Human Psychopharmacology: Measurements and Methods (eds I. Hindmarch & P. D. Stonier), Vol. 2, pp. 1–22. New York: Wiley.Google Scholar
Wolfe, N., Katz, D. I., Albert, M. L., et al (1990) Neuropsychological profile linked to low dopamine: in Alzheimer's disease, major depression, and Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry, 53, 915–917.Google Scholar
Wong, D. F., Wagner, H. N., Tune, L. E., et al (1986) Positron emission tomography reveals elevated D2 dopamine receptors in drug-naïve schizophrenics. Science, 234, 1558–1563.Google Scholar
Wong, D. F., Tune, L., Shaya, E., et al (1992) The comparison of dopamine receptor density measured by C-11 raclopride and NMSP in the same living human brain. Journal of Nuclear Medicine, 33, 847.Google Scholar
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