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Caudate Nucleus Morphology in Tardive Dyskinesia

Published online by Cambridge University Press:  02 January 2018

Keith W. Brown ,
Thomas White ,
J. M. Wardlaw ,
Nicholas Walker  and
D. Foley
Keith W. Brown*
Affiliation:
Central Scotland Healthcare Trust, Bellsdyke Hospital, Larbert
Thomas White
Affiliation:
State Hospital, Lanark
J. M. Wardlaw
Affiliation:
Department of Clinical Neurosciences, Western General Hospital, Edinburgh
Nicholas Walker
Affiliation:
Leverndale Hospital, Glasgow
D. Foley
Affiliation:
Department of Neuroradiology, Institute of Neurological Sciences, Southern General Hospital, Glasgow
*
Dr Keith W. Brown, Consultant Psychiatrist, Central Scotland Healthcare Trust, Bellsdyke Hospital, Larbert FK5 4SF
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Abstract

Objective

The objective of this project was to test whether there are differences in the size of the caudate nucleus in schizophrenic in-patients with and without tardive dyskinesia.

Method

The study was cross-sectional in design, examining group differences between institutionalised schizophrenic patients with and without tardive dyskinesia, using non-enhanced computerised tomography scans of the brain. The group comprised 15 schizophrenic patients with persistent tardive dyskinesia and 21 in-patient schizophrenic controls who were group-matched for demographic variables.

Results

The dyskinetic subjects had a significantly larger left caudate nucleus and tended to have a larger right caudate nucleus than the controls. There were no differences between the groups on any of the measures of cerebral atrophy.

Conclusions

The findings can be understood within the context of models of neostriatal function. It is possible that a larger caudate nucleus could be used to identify patients at risk of developing tardive dyskinesia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 169 , Issue 5 , November 1996 , pp. 631 - 636
Copyright
Copyright © Royal College of Psychiatrists, 1996 

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