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A Case of Craniopharyngioma Presenting as Korsakov's Syndrome

Published online by Cambridge University Press:  29 January 2018

G. Palmai ,
D. C. Taylor  and
Murray A. Falconer
G. Palmai
Affiliation:
The Maudsley Hospital, Denmark Hill, London, S.E.5
D. C. Taylor
Affiliation:
Guy's-Maudsley Neurosurgical Unit, De Crespigny Park, London, S.E.5
Murray A. Falconer
Affiliation:
Guy's-Maudsley Neurosurgical Unit, De Crespigny Park, London, S.E.5
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Extract

The particular mental state described by Korsakov (1890, 1891) is, in most cases, a sequel of Wernicke's encephalopathy, which itself is the result of alcoholism. Korsakov, however, also observed the same mental condition in persons, not alcoholic, who had been exposed to carbon monoxide, to phosphorus poisoning, or to profound toxic states. Within a few years, Monckenmoller (1899) and Meyer (1899) had each described the Korsakov state appearing late in the natural history of sarcomata of the sella turcica and third ventricle respectively. Delay et al. (1964) ably reviewed 108 instances in the literature of the association of cerebral tumour and Korsakov state, and concluded that cerebral tumour is most likely to lead to the Korsakov state if it leads to a bilateral lesion in the hippocampo - mamillo - thalamo - cingulate pathways, an observation previously made by Grünthal (1939), Kleist (1934), and Orthner (1957). By virtue of their possible situation, craniopharyngiomas are so placed anatomically that they are associated with the Korsakov state with disproportionate frequency compared to other intracranial tumours. However, in some of the reported cases the Korsakov features were tenuous, were a near terminal or postoperative event, or were outweighed by gross endocrine disturbances. Even so, only 3 out of 28 such cases described in the literature were diagnosed during life. Early diagnosis is thus extremely difficult, for the neurological signs are sparse and then are mainly ophthalmological, whilst the onset is insidious and accompanied by mental changes which deceptively suggest a functional basis to the whole picture.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 113 , Issue 499 , June 1967 , pp. 619 - 623
Copyright
Copyright © Royal College of Psychiatrists, 1967 

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References

Almeida Dias, A. (1933). “Über die Pathogenic der Geistesstörungen bei Erdheimtumoren.” Z. ges. Neurol, Psychiat., 148, 250–262.Google Scholar
Bleuler, M. (1954). Endokrinologische Psychiatrie. Stuttgart.Google Scholar
Bonhoeffer, K. (1904). “Der Korsakowschc Symptomenkomplex in seinen Beziehungen zu der verschiedenen Krankheitsformen.” Allg. Z. Psychiat., 61, 744–752.Google Scholar
Delay, J., Brion, S., and Derouesne, C. (1964). “Syndrome de Korsakoff et étiologie tumorale.” Rev. Neurol., 111, 97–133.Google Scholar
Grünthal, E. (1939). “Über das Corpus mamillare und den Korsakowschen Symptomenkomplex.” Confin. Neurol., 2, 64–95.Google Scholar
Hoenig, J., Anderson, E. W., Kenna, J. C., and Blunden, R. (1962). “Clinical and pathological aspects of the mnestic syndrome.” J. ment. Sci., 108, 541–559.Google Scholar
Kleist, K. (1934). “Kriegsverletzungen des Gehirns in ihrer Bedeutung für die Hirnlokalisation und Hirn-pathologie in Geistes und Nervenkrankheiten.” (ed. Bonhoeffer, ), Leipzig.Google Scholar
Korsakov, S. S. (1890). “Über eine besondere Form psychischer Stöning, combinirt mit multipler Neuritis.” Arch. f. Psychiat., 21, 669–704.Google Scholar
Korsakov, S. S. (1891). “Erinnerungstäuschungen (Pseudoremi-niscenzen) bei polyneuritischer Psychose.” Allg. Z. Psychiat., 47, 390–410.Google Scholar
Lang, F. (1924). “Ein Plattenepithelezystopapillom (Erd-heimscher Hypophysengang-tumor) des Infundi-bularbereiches mit hypophysärer Kachexie.” Wien. klin. Wschr., 37, 977–979.Google Scholar
Lewis, A. J. (1961). “Amnesic syndromes: psychopatho-logical aspect.” Proc. roy. Soc. Med., 54, 955–961.Google Scholar
Meyer, E. (1899). “Sarkom des dritten Ventrikels mit Metastasen im vierten Ventrikel.” Arch. Psychiat. Nervenkr., 32, 320–329.Google Scholar
Mönckenmöller, O., und Kaplan, L. (1899). “Symptomatisches Korsakow und Rückenmarkserkrankungen bei Hirntumor.” Allg. Z. Psychiat., 56, 706–724.Google Scholar
Orthner, H. (1957). “Pathologische Anatomie der vom Hypothalamus ausgelösten Bewusstseinsstörungen.” Premier Congris Intern. Sciences Neurologiques, 2, 77–96.Google Scholar
Riese, W. (1950). “Craniophyaryngiome chez une femme âgée de 57 ans. Hallucinations visuelles et auditives. Deuxième note sur la genèse des hallucinations survenant chez les malades atteints de lésions céré-brales.” Rev. Neurol., 82, 137–139.Google Scholar
Russell, R. W., and Pennybacker, J. (1961). “Craniopharyngioma in the elderly.” J. Neurol. Neurosurg. Psychiat., 24, 1–13.Google Scholar
Sivadon, P., Ajuriaguerra, J. de, et Barande, R. (1957). “Syndrome Korsakovien d'étiologie tumorale par compression du troisième ventricule.” Arm. méd-psychol., 115 (ii), 484–486.Google Scholar
Van der Horst, L. (1932). “Über die Psychologie des Korsakowsyndroms.” Mschr. Psychiat. Neurol., 83, 65–84.Google Scholar
Wagner, W. (1942). “Zum Problem affektiver Veränderungen bei Störungen im Bereich des Zwischenhirns.” Dtsch. Z. Nervenheilk., 154, 1–18.CrossRefGoogle Scholar
Williams, M., and Pennybacker, J. (1954). “Memory disturbances in third ventricle tumours.” J. Neurol. Neurosurg. Psychiat., 17, 115–123.Google Scholar
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