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Caffeine and Cerebral Blood Flow

Published online by Cambridge University Press:  29 January 2018

Roy J. Mathew ,
Deborah L. Barr  and
Maxine L. Weinman
Roy J. Mathew
Affiliation:
Department of Psychiatry, Vanderbilt University Hospital, Nashville, Tennessee 37232, USA
Deborah L. Barr
Affiliation:
Psychosomatic Research Section, Texas Research Institute of Mental Sciences, Houston, Texas, USA
Maxine L. Weinman
Affiliation:
Texas Research Institute of Mental Sciences, Houston, Texas, USA
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Summary

Two groups of normal volunteers had regional cerebral blood flow (rCBF) measured, by the 133Xenon inhalation technique, before and 30 minutes after 250 mg or 500 mg caffeine given orally. rCBF was measured in a third group of subjects, twice, at a similar interval under identical laboratory conditions. Subjects who received caffeine showed significant decreases in rCBF while the others showed no rCBF change from the first to the second measurement. However, the two caffeine groups did not differ in degrees of rCBF reduction. There were no regional variations in the post-caffeine decrease in cerebral blood flow. The three groups did not show significant changes in end-tidal carbon dioxide, pulse rate, blood pressure, forehead skin temperature and respiratory rate.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 143 , Issue 6 , December 1983 , pp. 604 - 608
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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