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Brain Electrolytes in Depressive and Alcoholic Suicides

Published online by Cambridge University Press:  29 January 2018

David Murray Shaw ,
Doris Frizel ,
Francis E. Camps  and
Stuart White
David Murray Shaw
Affiliation:
M.R.C. Neuropsychiatric Research Unit, Carshalton, and West Park Hospital, Epsom, Surrey
Doris Frizel
Affiliation:
M.R.C. Neuropsychiatric Research Unit, Carshalton, and West Park Hospital, Epsom, Surrey
Francis E. Camps
Affiliation:
Area Laboratory, West Park Hospital, Epsom, Surrey
Stuart White
Affiliation:
The London Hospital Medical School, London, E.1
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Extract

One of the hypotheses advanced to explain the processes underlying severe depression postulates a change in brain function due to an alteration in the distribution of cations across the neuronal membranes (Shaw and Coppen, 1966; Shaw, 1966). Electrophysiological evidence of abnormal function of pathways in the nervous system in depression has been obtained by the study of evoked cortical potentials (Shagass and Schwartz, 1966), but evidence of derangement in the distribution of cations between the cells and extracellular space has come only from “whole body” studies (Coppen and Shaw, 1963; Coppen, Shaw, Malleson and Costain, 1966; Shaw and Coppen, 1966).

Type
Biochemical and Metabolic Studies
Information
The British Journal of Psychiatry , Volume 115 , Issue 518 , January 1969 , pp. 69 - 79
Copyright
Copyright © Royal College of Psychiatrists, 1969 

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