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Brain Electrolytes in Depressive and Alcoholic Suicides

Published online by Cambridge University Press:  29 January 2018

David Murray Shaw ,
Doris Frizel ,
Francis E. Camps  and
Stuart White
David Murray Shaw
Affiliation:
M.R.C. Neuropsychiatric Research Unit, Carshalton, and West Park Hospital, Epsom, Surrey
Doris Frizel
Affiliation:
M.R.C. Neuropsychiatric Research Unit, Carshalton, and West Park Hospital, Epsom, Surrey
Francis E. Camps
Affiliation:
Area Laboratory, West Park Hospital, Epsom, Surrey
Stuart White
Affiliation:
The London Hospital Medical School, London, E.1
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Extract

One of the hypotheses advanced to explain the processes underlying severe depression postulates a change in brain function due to an alteration in the distribution of cations across the neuronal membranes (Shaw and Coppen, 1966; Shaw, 1966). Electrophysiological evidence of abnormal function of pathways in the nervous system in depression has been obtained by the study of evoked cortical potentials (Shagass and Schwartz, 1966), but evidence of derangement in the distribution of cations between the cells and extracellular space has come only from “whole body” studies (Coppen and Shaw, 1963; Coppen, Shaw, Malleson and Costain, 1966; Shaw and Coppen, 1966).

Type
Biochemical and Metabolic Studies
Information
The British Journal of Psychiatry , Volume 115 , Issue 518 , January 1969 , pp. 69 - 79
Copyright
Copyright © Royal College of Psychiatrists, 1969 

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References

Altschule, M. D., and Tillotson, K. J. (1949). “Effect of electroconvulsive therapy on water metabolism in psychotic patients.” Amer. J. Physiol., 105, 829–833.Google Scholar
Barondes, R. de R., Kuhns, R. H., Levine, D. I., and Strachan, C. E. (1949). “Psychotic states: correlations of biochemical and histologic changes in brain.” Military Surgeon, 104, 278–285.Google Scholar
Brown, D. G., Hullin, R. P., and Roberts, J. M. (1963). “Fluid distribution and the response of depression to E.C.T. and imipramine.” Brit. J. Psychiat., 109, 395–398.Google Scholar
Burton, K. (1956). “Study of conditions and mechanism of diphenylamine reaction for colorimetric estimation of deoxyribonucleic acid.” Biochem. J., 62, 315–323.Google Scholar
Coppen, A. J. (1967). Unpublished observations.Google Scholar
Coppen, A. J. and Shaw, D. M. (1963). “Mineral metabolism in melancholia.” Brit. med. J., ii, 1439–1444.Google Scholar
Coppen, A. J. and Shaw, D. M., Malleson, A., and Costain, R. (1966). “Mineral metabolism in mania.” Brit. med. J., i, 71–75.CrossRefGoogle Scholar
Davson, H. (1967). Physiology of the Cerebrospinal Fluid. London: J. and A. Churchill Ltd.Google Scholar
Dawson, J., Hullin, R. P., and Crocket, B. M. (1956). “Metabolic variations in manic-depressive psychosis.” J. ment. Sci., 102, 168–177.CrossRefGoogle Scholar
Eichhorn, O. (1954). “Über störungen des Kationengleichgewichtes bei Psychosen.” Wien. Z. Nervenheilk., 8, 261–293.Google Scholar
Folch, J., Lees, M., and Stanley, G. H. S. (1957). “A simple method for the isolation and purification of total lipides in animal tissues.” J. biol. Chem., 226, 497–509.Google Scholar
Himwich, W. A., and Himwich, H. E. (1959). “Neurochemistry of Aging.” In: Handbook of Aging and the Individual (ed. Birren, J. E.). Chicago: University of Chicago Press.Google Scholar
Hullin, R. P., Bailey, A. D., McDonald, R., Dransfield, G. A., and Milne, H. B. (1967a). “Variations in body water during recovery from depression.” Brit. J. Psychiat., 113, 573–583.Google Scholar
Hullin, R. P., Bailey, A. D., McDonald, R., Dransfield, G. A., and Milne, H. B. (1967b). “Body water variations in manic-depressive psychosis.” Brit. J. Psychiat., 113, 584–592.Google Scholar
Joyce, D. (1962). “Changes in 5-hydroxytryptamine content of rat, rabbit and human brain after death.” Brit. J. Pharmacol., 18, 370–380.Google Scholar
Kalint, H., and Israel, Y. (1967). “Effects of ethanol on active transport of cations.” In: Biochemical Factors in Alcoholism“ (ed. Maickel, R. P.). Oxford: Pergamon Press.Google Scholar
Lindegård, B. (1953). “Variations in human body build. A somatometric and X-ray cephalometric investigation on Scandinavian adults.” Acta psychiat. neurol. Scand., Suppl. 86.Google Scholar
Pregl, F. (1945). Quantitative Organic Microanalysis, 4th edition. London: Churchill.Google Scholar
Reynolds, E. H. In press.Google Scholar
Schachter, D. (1961). “Fluorimetric estimation of magnesium with 8-hydroxy-5-quinolinesulfonate.” J. lab. clin. Med., 58, 495–498.Google Scholar
Shagass, C., and Schwartz, M. (1966). “Somatosensory cerebral evoked responses in psychotic depression.” Brit. J. Psychiat., 112, 799–807.Google Scholar
Shaw, D. M. (1966). “Mineral metabolism, mania and melancholia.” Brit. med. J., ii, 262–267.Google Scholar
Shaw, D. M., and Coppen, A. J. (1966). “Potassium and water distribution in depression.” Brit. J. Psychiat., 112, 269–276.Google Scholar
Van Harreveld, A. (1966). Brain Tissue Electrolytes. London: Butterworths.Google Scholar
Van Harreveld, A., Growell, J., and Malhotra, S. K. (1965). “A study of extracellular space in central nervous system by freeze-substitution.” J. cell. Biol., 25, 117–137.Google Scholar
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