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Bipolar Affective Disorder Minus Left Prefrontal Cortex Equals Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Alfred Pang  and
Shôn W. Lewis
Alfred Pang*
Affiliation:
Chinese University of Hong Kong
Shôn W. Lewis
Affiliation:
University of South Manchester, Withington Hospital, Manchester M20 8LR
*
Alfred H. T. Pang, 11th floor, Prince of Wales Hospital, Shatin, NT, Hong Kong. Fax: (852) 26377884
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Abstract

Background

An investigation of the relationship between bipolar affective disorder and schizophrenia, following a severe head injury and removal of the left prefrontal cortex.

Method

A single case report.

Results

An individual with past history of bipolar affective disorder suffered traumatic damages to the left prefrontal cortex with a second lesion in the left temporal lobe. The patient developed typical schizophrenia nine months later. The relevance of his brain lesions in determining the schizophrenic symptoms is discussed.

Conclusion

We propose that the specific pattern of brain injury in this patient was sufficient to change the phenotype from bipolar affective disorder to schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 168 , Issue 5 , May 1996 , pp. 647 - 650
Copyright
Copyright © 1996 The Royal College of Psychiatrists 

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