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Behavioural and Subjective Effects of Beta-Adrenergic Blockade in Phobic Subjects

Published online by Cambridge University Press:  29 January 2018

M. W. Bernadt ,
T. Silverstone  and
W. Singleton
M. W. Bernadt*
Affiliation:
Academic Unit of Human Psychopharmacology, Medical Colleges of St. Bartholomew's and The London Hospitals, German Hospital, Ritson Road, London E8 1DF
T. Silverstone*
Affiliation:
Academic Unit of Human Psychopharmacology, Medical Colleges of St. Bartholomew's and The London Hospitals, German Hospital, Ritson Road, London E8 1DF
W. Singleton
Affiliation:
Pfizer Central Research, Pfizer A/S, Vestre Gade 18, Dk-2650 Hvidovre, Denmark
*
∗Now Research Worker, Institute of Psychiatry, De Crespigny Park, London SE5 9AF.
†Reprint requests.
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Summary

It has been suggested that reversal of stress-induced tachycardia by beta-adrenergic blockade might be of benefit in the treatment of phobias. This was tested in a double-blind cross-over trial by exposing 22 female volunteers with spider or snake phobias to their phobic object 1 ½ hours after administration of either tolamolol 200 mg, diazepam 10 mg or placebo. Although tolamolol abolished the stress-induced tachycardia, it had no beneficial behavioural or subjective effects. In contrast, diazepam, which had no significant effect on heart rate, improved behavioural performance. Subjective measures were more influenced by order effect than by medication.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 5 , November 1980 , pp. 452 - 457
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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References

Brewer, C. (1972) Beneficial effect of beta-adrenergic blockade on ‘exam nerves’. Lancet, ii, 435.CrossRefGoogle Scholar
Editorial (1979) Validity of cross-over trials. British Journal of Clinical Pharmacology, 8, 5–6.CrossRefGoogle Scholar
Eysenck, H. J. & Eysenck, S. B. G. (1964) Manual of the Eyscnck Personality Inventory. London: University of London Press.Google Scholar
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.Google Scholar
Gaind, R., Watson, J. P. & Marks, I. M. (1971) Some approaches to the treatment of phobic disorders. Proceedings of the Royal Society of Medicine, 64, 1118–20.Google Scholar
Gaind, R., Suri, A. K. & Thompson, J. (1975) Use of beta blockers as an adjunct in behavioural techniques. Scottish Medical Journal, 20, 284–6.Google Scholar
Gibbons, D. O. & Phillips, M. (1976) The effect of acebutolol on tachycardia and performance during competitive rifle shooting. British Journal of Clinical Pharmacology, 3, 516–17.Google Scholar
Hafner, J. & Milton, F. (1977) The influence of propranolol on the exposure in vivo of agoraphobics. Psychological Medicine, 7, 419–25.CrossRefGoogle ScholarPubMed
Hills, M. & Armitage, P. (1979) The two-period crossover clinical trial. British Journal of Clinical Pharmacology, 8, 7–20.Google Scholar
Hodgson, R. & Rachman, S. (1974) II Desynchrony in measures of fear. Behaviour Research and Therapy, 12, 319–26.Google Scholar
Imhof, P. R., Blatter, K., Fuccella, L. M. & Turri, M. (1969) Beta-blockade and emotional tachycardia; radiotelemetric investigations in ski jumpers. Journal of Applied Physiology, 27, 366–9.CrossRefGoogle ScholarPubMed
James, I. M., Pearson, R. M., Griffith, D. N. W. & Newbury, P. (1977) Effect of oxprenolol on stage-fright in musicians. Lancet, ii, 952–4.Google Scholar
Krishnan, G. (1975) Oxprenolol in the treatment of examination nerves. Scottish Medical Journal, 20, 288–9.Google Scholar
Lang, P. J., Melamed, B. G. & Hart, J. (1970) A psychophysiological analysis of fear modification using an automated desensitisation procedure. Journal of Abnormal Psychology, 76, 220–34.CrossRefGoogle Scholar
Lang, P. J. (1971) The application of psychophysiological methods to the study of psychotherapy and behaviour modification. In Handbook of Psychotherapy and Behaviour Change (eds. A. E. Bergin and S. C. Garfield). New York: John Wiley and Sons Inc.Google Scholar
Liden, S. & Gottfries, C.-G. (1974) Beta-blocking agents in the treatment of catechol-induced symptoms in musicians. Lancet, ii, 529.Google Scholar
Marks, I. M. (1969) Fears and Phobias, p. 107–9. London: William Heinemann Ltd.Google Scholar
Marks, I. M., Marset, P., Boulougouris, J. & Huson, J. (1971) Physiological accompaniments of neutral and phobic imagery. Psychological Medicine, 1, 299–307.Google Scholar
Marks, I. M., Viswanathan, R., Lipsedge, M. S. & Gardner, R. (1972) Enhanced relief of phobias by flooding during waning diazepam effect. British Journal of Psychiatry, 121, 493–505.CrossRefGoogle ScholarPubMed
Marsden, C. D., Foley, T. H., Owen, D. A. L. & McAllister, R. G. (1967) Peripheral B-adrenergic receptors concerned with tremor. Clinical Science, 33, 53–65.Google Scholar
Nunes, J. S. & Marks, I. M. (1975) Feedback of true heart rate during exposure in vivo. Archives of General Psychiatry, 32, 933–6.Google Scholar
Nunes, J. S. & Marks, I. M. (1976) Feedback of true heart rate during exposure in vivo. Partial replication with methodological improvement. Archives of General Psychiatry, 33, 1346–50.Google Scholar
Salkind, M. R. (1973) The construction and validation of a self-rating anxiety inventory. Ph.D. thesis, University of London.Google Scholar
Sartory, G., Rachman, S. & Grey, S. (1977) An investigation of the relation between reported fear and heart rate. Behaviour Research and Therapy, 15, 435–8.Google Scholar
Shand, D. G. (1976) Pharmacokinetics of propanolol: a review. Postgraduate Medical Journal, 52, (Suppl. 4) 22–5.Google Scholar
Stephen, S. A. (1966) Unwated effects of propanolol. American Journal of Cardiology, 18, 463–8.Google Scholar
Taggart, P. & Carruthers, M. (1972) Suppression by oxprenolol of adrenergic response to stress. Lancet, ii, 256–8.Google Scholar
Taggart, P., Carruthers, M. & Somerville, W. (1973) Electrocardiogram plasma catecholamines and lipids, and their modification by oxprenolol when speaking before an audience. Lancet, ii, 341–6.Google Scholar
Taggart, P., Hedworth-Whitty, R., Carruthers, M. & Gordon, P. D. (1976) Observations on electrocardiogram and plasma catecholamines during dental procedures: the forgotten vagus. British Medical Journal, ii, 787–9.Google Scholar
Taylor, S. H. & Meeran, M. K. (1973) Different effects of adrenergic beta-receptor blockade on heart rate response to mental stress, catecholamines, and exercise. British Medical Journal, iv, 257–9.Google Scholar
Tyrer, P. J. & Lader, M. H. (1973) Effects of beta adrenergic blockade with sotalol in chronic anxiety. Clinical Pharmacology and Therapeutics, 14, 418–26.CrossRefGoogle ScholarPubMed
Tyrer, P. J. & Lader, M. H. (1974a) Physiological and psychological effects of $-propranolol, +-propranolol and diazepam in induced anxiety. British Journal of Clinical Pharmacology, 1, 379–85.CrossRefGoogle ScholarPubMed
Tyrer, P. J. & Lader, M. H. (1974b) Physiological response to propranolol and diazepam in chronic anxiety. British Journal of Clinical Pharmacology, 1, 387–90.Google Scholar
Watson, J. P., Gaind, R. & Marks, I. M. (1971) Prolonged exposure: a rapid treatment for phobias. British Medical Journal, i, 13–15.Google Scholar
Wolfe, J. & Lang, P. J. (1964) A fear survey schedule for use in behaviour therapy. Behaviour Research and Therapy, 2, 27–30.Google Scholar
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