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Autosomal Dominant Gene Transmission in a Large Kindred with Gilles de la Tourette Syndrome

Published online by Cambridge University Press:  02 January 2018

David Curtis ,
Mary M. Robertson  and
Hugh M. D. Gurling
David Curtis
Affiliation:
Academic Department of Psychiatry, University College & Middlesex School of Medicine, Middlesex Hospital, Riding House Street, London W1P 7PN
Mary M. Robertson
Affiliation:
Academic Department of Psychiatry, University College & Middlesex School of Medicine, Middlesex Hospital, Riding House Street, London W1P 7PN
Hugh M. D. Gurling*
Affiliation:
Academic Department of Psychiatry, University College & Middlesex School of Medicine, Middlesex Hospital, Riding House Street, London W1P 7PN
*
∗Correspondence
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Abstract

A multiplex kindred ascertained through a single proband with GTS has been systematically investigated with standardised diagnostic instruments for other cases of GTS and related disorders. Complex segregation analysis supported the hypothesis that a single major gene inherited in autosomal dominant fashion but with incomplete penetrance contributed most of the variance in the liability to develop GTS and related disorders. This result is consistent with previous segregation analyses which have employed different methods of ascertainment, and tends to confirm that a proportion of GTS is due to a dominant gene and is suitable for investigation with genetic markers for linkage analysis.

Type
Papers
Information
The British Journal of Psychiatry , Volume 160 , Issue 6 , June 1992 , pp. 845 - 849
Copyright
Copyright © The Royal College of Psychiatrists 

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References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
Baraitser, M. (1982) The Genetics of Neurological Disorders. Oxford: Oxford University Press.Google Scholar
Comings, D., Comings, B. G., Devor, E. J., et al (1984) Detection of major gene for Gilles de la Tourette syndrome. American Journal of Human Genetics, 36, 586–600.Google ScholarPubMed
Devor, E. J. (1984) Complex segregation analysis of Gilles de la Tourette syndrome: further evidence for a major locus mode of transmission. American Journal of Human Genetics, 36, 704–709.Google Scholar
Gilles de la Tourette, G. (1885) Etude sur une affection nerveuse characterisee par l'incoordination motrice accompagnee d'echolalie et de copralalie. Archives of Neurology, 9, 19–42, 158–200.Google Scholar
Guggenheim, M. A. (1979) Familial Tourette syndrome. Annals of Neurology, 5, 104.CrossRefGoogle ScholarPubMed
Gurling, H. M. D. (1985) Application of molecular biology to mental illness. Analysis of genomic DNA and brain mRNA. Psychiatric Developments, 3, 257–273.Google ScholarPubMed
Gurling, H. M. D. (1986) Candidate genes and favoured loci: strategies for molecular genetic research into schizophrenia, manic depression, autism, alcoholism and Alzheimer's disease. Psychiatric Developments, 4, 289–309.Google ScholarPubMed
Itard, J. M. G. (1825) Memoire sur quelques fonctions involontaires des appareils de la locomotion de la prehension et de la voix. Archives of General Medicine, 8, 385–407.Google Scholar
Kurlan, R., Behr, J., Medved, L., et al (1986) Familial Tourette's syndrome: report of a large pedigree and potential for linkage analysis. Neurology, 36, 772–776.CrossRefGoogle ScholarPubMed
Kurlan, R., Behr, J., Medved, L., et al (1987) Severity of Tourette's syndrome in one large kindred: implication for determination of disease prevalence rate. Neurology, 44, 268–269.Google ScholarPubMed
Lalouel, J. M. & Morton, N. E. (1981) Complex segregation analysis with Pointers. Human Heredity, 31, 312–321.CrossRefGoogle ScholarPubMed
Lalouel, J. M. Rao, D. C., Morton, N. E., et al (1983) A unified model of complex segregation analysis. American Journal of Human Genetics, 35, 816–826.Google ScholarPubMed
Morton, N. E. & MacLean, C. J. (1974) Analysis of family resemblance III. Complex segregation analysis. American Journal of Human Genetics, 26, 489–503.Google Scholar
Morton, N. E., Rao, D. C. & Lalouel, J. M. (1983) Methods in Genetic Epidemiology. Basel: Karger.Google Scholar
Pauls, D. L. & Leckman, J. F. (1986) The inheritance of Gilles de la Tourette's syndrome and associated behaviors. New England Journal of Medicine, 315, 993–997.CrossRefGoogle ScholarPubMed
Pauls, D. L., Pakstis, A. J., Kurlan, R., et al (1990) Segregation and linkage analysis of Tourette's syndrome and related disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 195–203.CrossRefGoogle ScholarPubMed
Price, R. A., Pauls, D. L. & Caine, E. D. (1984) Pedigree and segregation analysis of clinically defined subgroups of Tourette syndrome. American Journal of Human Genetics, 36, 178.Google Scholar
Price, R. A., Kidd, K. K., Pauls, D. L., et al (1985) A twin study of Tourette's syndrome. Archives of General Psychiatry, 42, 815–820.CrossRefGoogle Scholar
Robertson, M. (1989) The Gilles de la Tourette syndrome: the current status. British Journal of Psychiatry, 154, 147–169.CrossRefGoogle ScholarPubMed
Robertson, M. & Gourdie, A. (1990) Familial Tourette's syndrome in a large British pedigree: associated psychopathology, severity and potential for linkage analysis. British Journal of Psychiatry, 156, 515–521.CrossRefGoogle Scholar
Zausmer, D. M. & Dewey, M. E. (1987) Tics and heredity. British Journal of Psychiatry, 150, 628–634.CrossRefGoogle ScholarPubMed
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