Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-04T21:41:26.817Z Has data issue: false hasContentIssue false
  • English
  • Français

Antipsychotic Drug-Induced Dysphoria

Published online by Cambridge University Press:  02 January 2018

D. J. King ,
M. Burke  and
R. A. Lucas
D. J. King*
Affiliation:
The Queen's University of Belfast and Holywell Hospital, Antrim, Northern Ireland
M. Burke
Affiliation:
Harris Laboratories, Belfast
R. A. Lucas
Affiliation:
Lilly Research Centre Ltd, Windlesham, Surrey
*
Dr King, Department of Therapeutics and Pharmacology, The Queen's University of Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Dysphoric reactions to antipsychotic medication are well recognised in association with akathisia, but can also occur independently.

Method

Fifty-one healthy volunteers were given haloperidol 5 mg in two consecutive pharmacokinetic studies.

Results

Dysphoria occurred in about 40% of the subjects on both occasions, but akathisia was only detected in 8% (first study) and 16% (second study). All adverse effects were transient and were abolished in nine of the ten subjects given procyclidine.

Conclusions

While dysphoria is a well-recognised reaction in healthy volunteers, it is probably insufficiently recognised in patients, particularly if it occurs in the absence of akathisia. Better detection could improve compliance in patients.

Type
Papers
Information
The British Journal of Psychiatry , Volume 167 , Issue 4 , October 1995 , pp. 480 - 482
Copyright
Copyright © 1995 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Anderson, B. G., Reker, D. & Cooper, T. B. (1981) Prolonged adverse effects of haloperidol in normal subjects. New England Journal of Medicine, 305, 643–644.Google Scholar
Drake, R. E. & Ehrlich, J. (1985) Suicide attempts associated with akathisia. American Journal of Psychiatry, 142, 499–501.Google ScholarPubMed
Halstead, S. M., Barnes, T. R. E. & Speller, J. C. (1994) Akathisia: prevalence and associated dysphoria in an in-patient population with chronic schizophrenia. British Journal of Psychiatry, 164, 177–183.Google Scholar
Hollister, L. E. (1992) Neuroleptic dysphoria: so what's new? Biological Psychiatry, 31, 531–532.Google Scholar
Johnstone, E. C., Crow, T. J., Ferrier, N., et al (1983) Adverse effects of anticholinergic medication on positive schizophrenic symptoms. Psychological Medicine, 13, 513–527.Google Scholar
King, D. J. (1994) Psychomotor impairment and cognitive disturbances induced by neuroleptics. Acta Psychiatrica Scandinavica, 89 (supplement 380), 53–58.Google Scholar
Kramer, M. S., Vogel, W. H., DiJohnson, C., et al (1989) Antidepressants in ‘depressed’ schizophrenic inpatients. Archives of General Psychiatry, 46, 922–928.Google Scholar
McEvoy, J. P., Hogarty, G. E. & Steingard, S. (1991) Optimal dose of neuroleptic in acute schizophrenia. A controlled study of the neuroleptic threshold and higher haloperidol dose. Archives of General Psychiatry, 48, 739–745.Google Scholar
Newcomer, J. W., Miller, L. S., Faustman, W. O., et al (1994) Correlations between akathisia and residual psychopathology: a by-product of neuroleptic-induced dysphoria. British Journal of Psychiatry, 164, 834–838.CrossRefGoogle ScholarPubMed
Spina, E., Sturiale, V., Valvo, S., et al (1993) Prevalence of acute dystonic reactions associated with neuroleptic treatment with and without anticholinergic prophylaxis. International Clinical Psychopharmacology, 8, 21–24.Google Scholar
van Putten, T. (1974) Why do schizophrenic patients refuse to take their drugs? Archives of General Psychiatry, 31, 67–72.Google Scholar
van Putten, T. (1975) The many faces of akathisia. Comprehensive Psychiatry, 16, 43–47.Google Scholar
World Health Organization Consensus Statement (1990) Prophylactic use of anticholinergics in patients on long-term neuroleptic treatment. British Journal of Psychiatry, 156, 412.Google Scholar
Young, C. S., Stewart, J. B. & Fenton, G. W. (1994) Neuroleptic medication for dystonia. Reciprocal relationship between effects on motor function and mood. British Journal of Psychiatry, 165, 384–386.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.