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Antidepressant Drug Therapy in Psychotic Depression

Published online by Cambridge University Press:  29 January 2018

Jonathan R. T. Davidson ,
Malcolm N. McLeod ,
Albert A. Kurland  and
Helen L. White
Jonathan R. T. Davidson*
Affiliation:
University of North Carolina; John Umstead Hospital, Butner, North Carolina
Malcolm N. McLeod
Affiliation:
Duke University, Durham, North Carolina; John Umstead Hospital, Butner, North Carolina
Albert A. Kurland
Affiliation:
Maryland Psychiatric Research Center, Baltimore, Maryland 21228
Helen L. White
Affiliation:
Burroughs Wellcome Laboratories, Research Triangle Park, North Carolina
*
Address correspondence to: Dr J. R. T. Davidson, Centre for Interpersonal Studies, 3188 Atlanta St S.E., Smyrna, Ga. 30080, USA.
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Abstract

Imipramine and phenelzine were ineffective in the treatment of five primary unipolar depressives with delusions, even when plasma levels of imipramine and desmethylimipramine or activity of platelet monoamine oxidase suggested that an adequate dose of drug had been given. Four patients went on to receive ECT and all responded well. Five non-delusional patients responded satisfactorily to the antidepressant drug given. Nine out of ten subjects were women. Non-delusional patients showed some placebo response.

ECT is considered to be the treatment of choice in the acute phase of delusional depression in women.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 131 , Issue 5 , November 1977 , pp. 493 - 496
Copyright
Copyright © Royal College of Psychiatrists, 1977 

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References

Carney, M. W. P., Roth, M. & Garside, R. F. (1965) The diagnosis of depressive syndromes and the prediction of ECT response. British Journal of Psychiatry, 111, 659–74.Google Scholar
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A. et al (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–73.Google Scholar
Glassman, A. H., Kantor, S. J. & Shostak, M. (1975) Depression, delusions and drug response. American Journal of Psychiatry, 132, 716–19.Google ScholarPubMed
Hordern, A., Holt, H. F., Burt, C. G. & Gordon, W. F. (1963) Amitriptyline in depressive states. British Journal of Psychiatry, 109, 815–25.Google Scholar
Kiloh, L. G., Ball, J. R. B. & Garside, R. F. (1962) Prognostic factors in treatment of depressive states with imipramine. British Medical Journal, i. 1225–9.Google Scholar
Klein, D. F. & Davis, J. M. (1969) Diagnosis and Drug Treatment of Psychiatric Disorder, ch 7. Williams and Wilkins.Google Scholar
Kuhn, R. (1958) The treatment of depressive states with G-22355 (imipramine hydrochloride). American Journal of Psychiatry, 115, 459–69.Google Scholar
Medical Research Council (1965) Clinical trial of the treatment of depressive illness. British Medical Journal, i, 881–6.Google Scholar
Moody, J. P., Tait, A. C. & Todrick, A. (1967) Plasma levels of imipramine and desmethylimipramine during therapy. British Journal of Psychiatry, 113, 183–8.Google Scholar
Morris, J. B. & Beck, A. T. (1974) The efficacy of antidepressant drugs. Archives of General Psychiatry, 30, 667–70.Google Scholar
Perel, J. M., Shostak, M., Gann, E., et al (1976). Pharmacodynamics of imipramine and clinical outcome in depressed patients in Pharmacokinetics of Psychotropic Drugs (eds Gottschalk, and Merlis, ). New York: Spectrum Publications (J. Wiley and sons) Google Scholar
Robinson, D. S., Lovenberg, W., Keiser, H. et al (1968) Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and vivo. Biochemical Pharmacology, 17, 109–19.Google Scholar
Rogers, S. C. & Clay, P. M. (1975) A statistical review of controlled trials of imipramine and placebo. British Journal of Psychiatry, 127, 599–603.Google Scholar
Ulett, G. A. (1975) More on the treatment of delusional depressive patients (letter to ed.). American Journal of Psychiatry, 132, 1332.Google Scholar
Wurtman, R. J. & Axelrod, J. (1963) A sensitive and specific assay for the estimation of monoamine oxidase. Biochemical Pharmacology, 12, 1439–40.Google Scholar
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