Hostname: page-component-78c5997874-4rdpn Total loading time: 0 Render date: 2024-11-05T12:45:50.479Z Has data issue: false hasContentIssue false
  • English
  • Français

Animal Studies of Alcohol Intake

Published online by Cambridge University Press:  29 January 2018

Richard A. Meisch
Richard A. Meisch*
Affiliation:
Departments of Psychiatry and Pharmacology, Box 392 Mayo, University of Minnesota, Minneapolis, Minnesota 55455, USA
Get access Rights & Permissions [Opens in a new window]

Extract

Animal studies of alcohol intake can be divided into two groups based on the methodology. General findings of each group will be reviewed especially as they relate to current areas of research interest. Some implications of research findings for theories of alcoholism and drug addiction will be mentioned.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 141 , Issue 2 , August 1982 , pp. 113 - 120
Copyright
Copyright © Royal College of Psychiatrists, 1982 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Altshuler, H. L., Weaver, S. & Phillips, P. (1975) Intragastric self-administration of psychoactive drugs by the rhesus monkey. Life Sciences, 17, 883–90.Google Scholar
Bigelow, G. & Liebson, G. (1972) Cost factors controlling alcoholic drinking. Psychological Record, 22, 305–14.Google Scholar
Branchey, M., Rauscher, G. & Kissin, B. (1971) Modifications in the response to alcohol following the establishment of physical dependence. Psychopharmacologia (Berl.), 22, 314–22.Google Scholar
Cappell, H. & Le Blanc, A. E. (1979) Tolerance to, and physical dependence on, ethanol: Why do we study them? Drug and Alcohol Dependence, 4, 15–31.Google Scholar
Carney, J. M., Llewellyn, M. E. & Woods, J. H. (1976) Variable interval responding maintained by intravenous codeine and ethanol injections in the rhesus monkey. Pharmacology Biochemistry and Behavior, 5, 577–82.Google Scholar
Carroll, M. E., France, C. P. & Meisch, R. A. (1979) Food deprivation increases oral and intravenous etonitazene intake in rats. Science, 205, 319–21.Google Scholar
Carroll, M. E., France, C. P. & Meisch, R. A. (1981) Intravenous self-administration of etonitazene, cocaine and phencyclidine in rats during food deprivation and satiation. Journal of Pharmacology and Experimental Therapeutics, 217, 241–7.Google Scholar
Carroll, M. E. & Meisch, R. A. (1978) Etonitazene as a reinforcer: Oral intake of etonitazene by rhesus monkeys. Psychopharmacology, 59, 225–9.Google Scholar
Carroll, M. E. & Meisch, R. A. (1979) Effects of food deprivation on etonitazine consumption in rats. Pharmacology Biochemistry and Behavior, 10, 155–9.Google Scholar
Carroll, M. E. & Meisch, R. A. (1980) Oral phencyclidine (PCP) self-administration in rhesus monkeys: Effects of feeding conditions. Journal of Pharmacology and Experimental Therapeutics, 214, 339–46.Google Scholar
Carroll, M. E. & Meisch, R. A. (1981) Determinants of increased drug self-administration due to food deprivation. Psychopharmacology, 74, 197–200.Google Scholar
Cooper, J. R., Bloom, F. E. & Roto, R. H. (1978) The Biochemical Basis of Neuropharmacology, New York: Oxford University Press Google Scholar
Davis, V. E. & Walsh, M. J. (1970) Alcohol, amines, and alkaloids: A possible biochemical basis for alcohol addiction. Science, 167, 1005–7.CrossRefGoogle ScholarPubMed
de la Garza, R., Bergman, J. & Hartel, C. R. (1981) Food deprivation and cocaine self-administration. Pharmacology Biochemistry and Behavior, 15, 141–4.Google Scholar
Deneau, G., Yanagita, T. & Seevers, M. H. (1969) Self-administration of psychoactive substances by the monkey: A measure of psychological dependence. Psychopharmacologia (Berl.), 16, 30–48.CrossRefGoogle Scholar
DeNoble, V. J. & Begleiter, H. (1978) Alcohol self-administration in monkeys (Macaca radiata): The effects of prior alcohol exposure. Pharmacology Biochemistry and Behavior, 8, 391–7.CrossRefGoogle ScholarPubMed
Duncan, C. & Dietrich, R. A. (1980) A critical evaluation of tetrahydroisoquinoline induced ethanol preference in rats. Pharmacology Biochemistry and Behavior, 13, 265–81.CrossRefGoogle ScholarPubMed
Eriksson, K. (1968) Genetic selection for voluntary alcohol consumption in the albino rat. Science, 159, 739–41.Google Scholar
Eriksson, K. (1980) Inherited metabolism and behavior towards alcohol: Critical evaluation of human and animal research. In Animal Models in Alcohol Research (eds. Eriksson, K., Sinclair, J. D. and Kiianmaa, K.). London: Academic Press.Google Scholar
Falk, J. L. (1961) Production of polydipsia in normal rats by an intermittent food schedule. Science, 133, 195–6.CrossRefGoogle ScholarPubMed
Falk, J. L. (1969) Conditions producing psychogenic polydipsia in animals. Annals of the New York Academy of Sciences, 157, 569–93.Google Scholar
Falk, J. L. (1971) The nature and determinants of adjunctive behavior. Physiology and Behavior, 6, 577–88.CrossRefGoogle ScholarPubMed
Falk, J. L. Samson, H. H. & Winger, G. (1972) Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat. Science, 177, 811–13.CrossRefGoogle ScholarPubMed
Freund, G. (1969) Alcohol withdrawal syndrome in mice. Archives of Neurology, 21, 315–20.CrossRefGoogle ScholarPubMed
Garcia, J., Hankins, W. G. & Rusiniak, K. W. (1974) Behavioral regulation of the milieu interne in man and rat. Science, 185, 824–31.Google Scholar
Goldberg, S. R. (1976) The behavioral analysis of drug addiction. In Behavioral Pharmacology (eds. Glick, S. D. and Goldfarb, J.). Englewood Cliffs, NJ: C. V. Mosby.Google Scholar
Goldberg, S. R. Morse, W. H. & Goldberg, D. M. (1976) Behavior maintained under a second-order schedule by intramuscular injection of morphine or cocaine in rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics, 199, 278–86.Google ScholarPubMed
Goldberg, S. R. Spealman, R. D. & Goldberg, D. M. (1981) Persistent behavior at high rates maintained by intravenous self-administration of nicotine. Science, 214, 573–5.Google Scholar
Griffiths, R. R., Bigelow, G. E. & Henningfield, J. E. (1980) Similarities in animal and human drug-taking behavior. In Advances in Substance Abuse, Vol 1 (ed. Mello, N. K.). Greenwich, Connecticut: JAI Press Google Scholar
Henningfield, J. E. & Meisch, R. A. (1979) Ethanol drinking by rhesus monkeys with concurrent access to water. Pharmacology Biochemistry and Behavior, 10, 777–82.CrossRefGoogle ScholarPubMed
Ho, A. K. S., Tsai, C. S., Chen, R. C. A., Begleiter, H. & Kissin, B. (1974) Experimental studies on alcoholism I. Increase in alcohol preference by 5,6-dihydroxytryptamine and brain acetylcholine. Psychopharmacologia (Berl.), 40, 101–7.Google Scholar
Hoffmeister, F. & Goldberg, S. R. (1973) A comparison of chlorpromazine, imipramine, morphine and d-amphetamine self-administration in cocaine-dependent rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics, 187, 8–14.Google ScholarPubMed
Hoffmeister, F. (1977) Reinforcing properties of perphenazine, haloperidol and amitryptiline in rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics, 200, 516–22.Google Scholar
Hoffmeister, F. & Wuttke, W. (1975) Further studies on self-administration of antipyretic analgesics and combinations of antipyretic analgesics with codeine in rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics, 193, 870–5.Google ScholarPubMed
Hunt, G. M. & Azrin, N. H. (1973) A community-reinforcement approach to alcoholism. Behaviour Research and Therapy, 11, 91–104.CrossRefGoogle ScholarPubMed
Johanson, C. E. (1978) Drugs as reinforcers. In Contemporary Research in Behavioral Pharmacology (eds. Blackman, D. E. and Sanger, D. J.). New York: Plenum Press.Google Scholar
Johanson, C. E. & Balster, R. L. (1978) A summary of the results of a drug self-administration study using substitution procedures in rhesus monkeys. Bulletin on Narcotics, 30, 43–54.Google Scholar
Kakihana, R. & Butte, J. C. (1980) Biochemical correlates of inherited drinking in laboratory animals. In Animal Models in Alcohol Research (eds. Eriksson, K., Sinclair, J. D. and Kiianmaa, K.). London: Academic Press.Google Scholar
Kandel, D. A. & Schuster, C. R. (1977) An investigation of nalorphine and perphenazine as negative reinforcers in an escape paradigm. Pharmacology Biochemistry and Behavior, 6, 61–71.CrossRefGoogle Scholar
Karoly, A. J., Winger, G., Ikomi, F. & Woods, J. H. (1978) The reinforcing property of ethanol in the rhesus monkey. II. Some variables related to the maintenance of intravenous ethanol-reinforced responding. Psychopharmacology, 58, 19–25.Google Scholar
Katz, J. L. (1979) A comparison of responding maintained under second-order schedules of intramuscular cocaine injection or food presentation in squirrel monkeys. Journal of the Experimental Analysis of Behavior, 32, 419–31.CrossRefGoogle ScholarPubMed
Kiianmaa, K. (1976) Alcohol intake in the rat after lowering brain 5-hydroxytryptamine content by electrolytic raphe lesions, 5,6-dihydroxytryptamine or p-chloro-phenylalanine. Medical Biology, 54, 203–9.Google Scholar
Kliner, D. J. & Meisch, R. A. (1982) The effects of food deprivation and satiation on oral pentobarbital self-administration in rhesus monkeys. Pharmacology Biochemistry and Behavior, 16, 579–84.Google Scholar
Lester, D. (1961) Self-maintenance of intoxication in the rat. Quarterly Journal of Studies on Alcohol, 22, 223–31.Google Scholar
Li, T.-K., Lumeng, L., McBride, W. J. & Waller, M. B. (1979) Progress toward a voluntary oral consumption model of alcoholism. Drug and Alcohol Dependence, 4, 45–60.Google Scholar
Malila, A. (1978) Intoxicating effects of three aliphatic alcohols and barbital on two rat strains genetically selected for their ethanol intake. Pharmacology Biochemistry and Behavior, 8, 197–201.Google Scholar
McClearn, G. E. & Rodgers, D. A. (1961) Genetic factors in alcohol preference of laboratory mice. Journal of Comparative and Physiological Psychology, 54, 116–19.Google Scholar
Meisch, R. A. (1975) The function of schedule-induced polydipsia in establishing ethanol as a positive reinforcer. Pharmacological Reviews, 27, 465–73.Google Scholar
Meisch, R. A. (1977) Ethanol self-administration: Infrahuman studies. In Advances in Behavioral Pharmacology, Vol. 1 (eds. Thompson, T. and Dews, P. B.). New York: Academic Press Google Scholar
Meisch, R. A. & Beardsley, P. (1975) Ethanol as a reinforcer for rats: Effects of concurrent access to water and alternate positions of water and ethanol. Psychopharmacologia (Berl.), 43, 19–23.Google Scholar
Meisch, R. A. & Henningfield, J. E. (1977) Drinking of ethanol by rhesus monkeys: Experimental strategies for establishing ethanol as a reinforcer. Advances in Experimental Medicine and Biology, 85B, 443–63.Google Scholar
Meisch, R. A. & Kliner, D. J. (1979) Etonitazene as a reinforcer for rats: Increased etonitazene-reinforced behavior due to food deprivation. Psychopharmacology, 63, 97–8.Google Scholar
Meisch, R. A. & Stark, L. J. (1977) Establishment of etonitazene as a reinforcer for rats by use of schedule-induced drinking. Pharmacology Biochemistry and Behavior, 7, 195–203.Google Scholar
Meisch, R. A. & Thompson, T. (1973) Ethanol as a reinforcer: Effects of fixed-ratio size and food deprivation. Psychopharmacologia (Berl.), 28, 171–83.Google Scholar
Meisch, R. A. & Thompson, T. (1974) Ethanol as a reinforcer: An operant analysis of ethanol dependence. In Drug Addiction Volume 3 Neurobiology and Influences on Behavior (eds. Singh, J. M. and Lal, H.). Miami: Stratton Intercontinental Medical Book Corporation.Google Scholar
Meisch, R. A. Kliner, D. J. & Henningfield, J. E. (1981) Pentobarbital drinking by rhesus monkeys: Establishment and maintenance of pentobarbital-reinforced behavior. Journal of Pharmacology and Experimental Therapeutics, 217, 114–20.Google ScholarPubMed
Melchior, C. L. & Myers, R. D. (1976) Genetic differences in ethanol drinking of the rat following injection of 6-OHDA, 5,6-DHT or 5,7-DHT into the cerebral ventricles. Pharmacology Biochemistry and Behavior, 5, 63–72.Google Scholar
Melchior, C. L. & Myers, R. D. (1977) Preference for alcohol evoked by tetra-hydropapaveroline (THP) chronically infused in the cerebral ventricle of the rat. Pharmacology Biochemistry and Behavior, 7, 19–35.Google Scholar
Mello, N. K. & Mendelson, J. H. (1972) Drinking patterns during work-contingent and noncontingent alcohol acquisition. Psychosomatic Medicine, 34, 139–64.Google Scholar
Myers, R. D. (1978) Psychopharmacology of alcohol. Annual Review of Pharmacology and Toxicology, 18, 125–44.Google Scholar
Myers, R. D. & Melchior, C. L. (1975) Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain. Research Communications in Chemical Pathology and Pharmacology, 10, 363–77.Google Scholar
Myers, R. D. Stoltman, W. P. & Martin, G. E. (1972) Effects of ethanol dependence induced artificially in the rhesus monkey on the subsequent preference for ethyl alcohol. Physiology and Behavior, 9, 43–8.Google Scholar
Myers, R. D. & Veale, W. L. (1968) Alcohol preference in the rat: reduction following depletion of brain serotonin. Science, 160, 1469–71.CrossRefGoogle ScholarPubMed
Nachman, M., Lester, D. & Le Magnen, J. (1970) Alcohol aversion in the rat: Behavioral assessment of noxious drug effects. Science, 168, 1244–6.Google Scholar
Nathan, P. E., O'Brien, J. S. & Lowenstein, L. M. (1971) Operant studies of chronic alcoholism: Interaction of alcohol and alcoholics. In Biological Aspects of Alcohol (eds. Roch, M. K., McIsaas, W. M., and Creaven, P. J.). Austin: University of Texas Google Scholar
Nkander, P. & Pekkanen, L. (1977) An inborn alcohol tolerance in alcohol preferring rats. The lack of relationship between tolerance to ethanol and the brain microsomal (Na+ K+) ATPase activity. Psychopharmacology, 51, 219–23.Google Scholar
Papasava, M., Oei, T. P. S. & Singer, G. (1981) Low dose cocaine self-administration by naive rats: Effects of body weight and a fixed-time one minute food delivery schedule. Pharmacology Biochemistry and Behavior, 15, 485–8.Google Scholar
Parker, L. F. & Radow, B. L. (1976) Effects of para-chlorophenylalanine on ethanol self-selection in the rat. Pharmacology Biochemistry and Behavior, 4, 535–40.CrossRefGoogle ScholarPubMed
Pieper, W. A. & Skeen, M. J. (1972) Induction of physical dependence on ethanol in rhesus monkeys using an oral acceptance technique. Life Sciences, 11, 989–97.CrossRefGoogle Scholar
Pieper, W. A. Skeen, M. J. McClure, H. M. & Bourne, P. G. (1972) The chimpanzee as an animal model for investigating alcoholism. Science, 176, 71–3.CrossRefGoogle ScholarPubMed
Poling, A. & Appel, J. B. (1979) Procedures for reducing drug intake: Nonhuman studies. In Advances in Behavioral Pharmacology, Vol. 2. (eds. Thompson, T. and Dews, P. B.). New York: Academic Press Google Scholar
Richardson, J. S. & Novakovski, D. M. (1978) Brain monoamines and free choice ethanol consumption in rats. Drug and Alcohol Dependence, 4, 15–31.Google Scholar
Richter, C. P. & Campbell, K. H. (1940) Alcohol taste thresholds and concentrations of solution preferred by rats. Science, 91, 507–8.CrossRefGoogle ScholarPubMed
Rodgers, D. A. & McClearn, G. E. (1962) Mouse strain differences in preference for various concentrations of alcohol. Quarterly Journal of Studies on Alcohol, 23, 26–33.Google Scholar
Samson, H. H. & Falk, J. L. (1974) Alteration of fluid preference in ethanol-dependent animals. Journal of Pharmacology and Experimental Therapeutics, 190, 365–76.Google Scholar
Seevers, M. H. (1970) Morphine and ethanol physical dependence: A critique of a hypothesis. Science, 170, 1113–14.Google Scholar
Skinner, B. F. (1969) Contingencies of Reinforcement. New York: Appleton-Century-Crofts.Google Scholar
Spealman, R. D. & Goldberg, S. R. (1978) Drug self-administration by laboratory animals: Control by schedules of reinforcement. Annual Review of Pharmacology and Toxicology, 18, 313–39.CrossRefGoogle ScholarPubMed
Stein, J. M., Wayner, M. J. & Tilson, H. A. (1977) The effect of parachlorophenylalanine on the intake of ethanol and saccharin solutions. Pharmacology Biochemistry and Behavior, 6, 117–22.CrossRefGoogle ScholarPubMed
Tampier, L., Quintanilla, M. E. & Mardones, J. (1981) Genetic differences in tolerance to ethanol: A study in UChA and UChB rats. Pharmacology Biochemistry and Behavior, 14, 165–8.Google Scholar
Thompson, T., Griffiths, R. & Pickens, R. (1973) Behavioral variables influencing drug self-administration by animals: Implications for controlling human drug use. In Psychic Dependence (eds. Goldberg, L. and Hoffmeister, F.). Berlin: Springer-Verlag.Google Scholar
Thompson, T. & Schuster, C. R. (1964) Morphine self-administration, food-reinforced, and avoidance behaviors in rhesus monkeys. Psychopharmacologia (Berl.), 5, 87–94.Google Scholar
Weeks, J. R. (1962) Experimental morphine addiction: Method for automatic intravenous injections in unrestrained rats. Science, 138, 143–4.Google Scholar
Winger, G. D. & Woods, J. H. (1973) The reinforcing property of ethanol. I. Initiation, maintenance and termination of ethanol-reinforced responding. Annals of the New York Academy of Sciences, 215, 162–75.Google Scholar
Wood, R. W., Grubman, J. & Weiss, B. (1977) Nitrous oxide self-administration by the squirrel monkey. Journal of Pharmacology and Experimental Therapeutics, 202, 491–9.Google Scholar
Yanagita, T. & Takahashi, S. (1973) Dependence liability of several sedative-hypnotic agents evaluated in monkeys. Journal of Pharmacology and Experimental Therapeutics, 185, 307–16.Google ScholarPubMed
Yanagita, T. Takahashi, S. Ishida, K. & Funamoto, H. (1970) Voluntary inhalation of volatile anesthetics and organic solvents by monkeys. Japanese Journal of Clinical Pharmacology, 1, 13–16.Google Scholar
York, J. L. (1981) Consumption of intoxicating beverages by rats and mice exhibiting high and low preferences for ethanol. Pharmacology Biochemistry and Behavior, 15, 207–14.Google Scholar
York, J. L. (1981) The ethanol stimulus in rats with differing ethanol preferences. Psychopharmacology, 74, 339–43.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.