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An Inverse Correlation between Spontaneous Eye-Blink Rate and Platelet Monoamine Oxidase Activity

Published online by Cambridge University Press:  29 January 2018

Craig N. Karson ,
Joel E. Kleinman ,
Karen Faith Berman ,
Bruce H. Phelps ,
C. D. Wise ,
Lynn E. DeLisi  and
Dilip V. Jeste
Craig N. Karson
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
Joel E. Kleinman
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
Karen Faith Berman
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
Bruce H. Phelps
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
C. D. Wise
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
Lynn E. DeLisi
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
Dilip V. Jeste
Affiliation:
Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington, DC 20032, USA
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Summary

An inverse correlation between platelet monoamine oxidase activity and spontaneous eye-blink rate, a putative measure of central dopaminergic activity, was found in medication-free chronic schizophrenic patients without tardive dyskinesia (n = 20, rs = -.47, P <.025). A similar correlation was found when patients with tardive dyskinesia were included but was weaker (n = 27, rs = -.35, P <.05). Normal controls and patients with tardive dyskinesia did not demonstrate this relationship. This report confirms a previous finding of a significant platelet monoamine oxidase-blink rate correlation in chronic schizophrenic patients. Insofar as this relationship is mediated by dopamine, it suggests that dopaminergic relations are more readily demonstrated in schizophrenic subjects than normals. Moreover, tardive dyskinesia appears to obscure this dopaminergic relationship.

Type
Papers
Information
The British Journal of Psychiatry , Volume 142 , Issue 1 , January 1983 , pp. 43 - 46
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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References

Carlsson, A. & Lindqvist, R. (1963) The effect of chlorpromazine and haloperidol on formation of 3-methoxytyramine and normetanephrine in mouse brain. Acta Pharmacologica et Toxicologica, 20, 140–4.CrossRefGoogle Scholar
Corash, L., Schaffer, B. & Perlow, M. (1979) Heterogeneity of human whole blood platelet subpopulations. II. Use of sub-human primate model to analyze the relationship between density and platelet age. Blood, 52, 726–34.Google Scholar
DeLisi, L. E., Wise, C. D., Bridge, T. P., Rosenberg, J. E., Wagner, R. L., Morihisa, J., Karson, C., Potkin, S. G. & Wyatt, R. J. (1981a) A probable neuroleptic effect on platelet monoamine oxidase in chronic schizophrenic patients. Psychiatry Research, 4, 95–107.Google Scholar
Freed, W. J., Kleinman, J. E., Karson, C. N., Potkin, S. G., Murphy, D. L. & Wyatt, R. L. (1980) Eye-blink rates and platelet monoamine oxidase activity in chronic schizophrenic patients. Biological Psychiatry, 15, 329–32.Google ScholarPubMed
Hall, A. (1975) The origin and purposes of blinking. British Journal of Ophthalmology, 29, 445–67.Google Scholar
Hornykiewicz, O. (1974) The mechanisms of action of 1-dopa in Parkinson's disease. Life Science, 15, 1249–59.Google Scholar
Jeste, D. V. & Wyatt, R. J. (1982) Understanding and Treating Tardive Dyskinesia. New York: Guilford Press.Google Scholar
Jeste, D. V., Kleinman, J. E., Potkin, S. G., Luchins, D. J. & Weinberger, D. R. (1982) Ex uno multi: Subtyping the schizophrenic syndrome. Biological Psychiatry, 17, 199–222.Google Scholar
Karson, C. N., Berman, K. F., Donnelly, E. F., Mendelson, W. B., Kleinman, J. E. & Wyatt, R. J. (1981d) Speaking, thinking and blinking. Psychiatry Research, 5, 243–6.CrossRefGoogle ScholarPubMed
Karson, C. N., Freed, W. J., Kleinman, J. E., Bigelow, L. B. & Wyatt, R. J. (1981a) Neuroleptics decrease blinking in schizophrenic subjects. Biological Psychiatry, 16, 679–82.Google Scholar
Karson, C. N., LeWitt, P. A., Calne, D. B. & Wyatt, R. J. (1982) Blink rates in parkinsonism. Annals of Neurology. (In press).Google Scholar
Karson, C. N., Staub, R. A., Kleinman, J. E. & Wyatt, R. J. (1981c) Drug effects on blink rates in rhesus monkeys. Biological Psychiatry, 16, 249–54.Google ScholarPubMed
Karson, C. N., Staub, R. A., Kleinman, J. E. & Wyatt, R. J. (1981b) Blink rates and receptor supersensitivity. Neuropharmacology, 20, 91–3.Google Scholar
Kleinman, J. E., Potkin, S. G., Rogol, A., Buchsbaum, M. S., Gillin, J. C., Murphy, D. L., Nasrallah, H. A. & Wyatt, R. J. (1979) A correlation between platelet monoamine oxidase activity and plasma prolactin concentrations in man. Science, 206, 479–81.Google Scholar
Meltzer, H. Y., Jackman, H., Arora, R. C., Sahai, S. & Duncavage, M. (1980) The effect of neuroleptic drugs on platelet monoamine oxidase activity. Psychopharmacology Bulletin, 17, 26–8.Google Scholar
Murphy, D. L. & Wyatt, R. J. (1972) Reduced platelet monoamine oxidase activity in chronic schizophrenia. Nature, 238, 225–6.Google Scholar
Owen, F., Bourne, R. C., Crow, T. J., Fadhil, A. A. & Johnstone, E. C. (1981) Platelet monoamine oxidase activity in acute schizophrenia: Relationship to symptomatology and neuroleptic medication. British Journal of Psychiatry, 139, 16–22.Google Scholar
Reveley, M. A., Glover, V., Sandler, M. & Spokes, E. G. (1981) Brain monoamine oxidase activity in schizophrenics and controls. Archives of General Psychiatry, 38, 663–5.Google Scholar
Siegel, S. (1956) Non-parametric Statistics for the Behavioural Sciences. New York: McGraw-Hill.Google Scholar
Spitzer, R. L., Endicott, J. & Robbins, R. (1977) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders. New York: Biometric Research.Google Scholar
Stevens, J. R. (1978) Eye blink and schizophrenia: Psychosis or tardive dyskinesia? American Journal of Psychiatry, 135, 223–7.Google Scholar
Schwartz, M. A., Aikens, A. M. & Wyatt, R. J. (1974) Monoamine oxidase activity in brains from schizophrenics and mentally normal individuals. Psychopharmacologica, 38, 319–28.Google ScholarPubMed
Thorner, M. O. (1977) Prolactin. Clinical Endocrinology and Metabolism, 6, 201–22.Google Scholar
Wise, C. D., Potkin, S. G., Bridge, R. P., Phelps, B. H., Cannon-Spoor, H. E. & Wyatt, R. J. (1980) Sources of error in the determination of platelet monoamine oxidasae. Schizophrenia Bulletin, 6, 245–53.Google Scholar
Wurtman, R. J. & Axelrod, J. (1963) A sensitive and specific assay for the estimation of monoamine oxidase. Biochemical Pharmacology, 12, 1439–40.Google Scholar
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