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An Examination of Linkage of Schizophrenia and Schizoaffective Disorder to the Pseudoautosomal Region (Xp22.3)

Published online by Cambridge University Press:  02 January 2018

Timothy J. Crow ,
Lynn E. Delisi ,
Raymond Lofthouse ,
Mark Poulter ,
Thomas Lehner ,
Nicholas Bass ,
Tarulata Shah ,
Catherine Walsh ,
Angela Boccio-Smith  and
Gail Shields
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Timothy J. Crow*
Affiliation:
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex HA1 3UJ, UK
Lynn E. Delisi
Affiliation:
Department of Psychiatry, SUNY, Stony Brook, New York, USA
Raymond Lofthouse
Affiliation:
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex HA1 3UJ, UK
Mark Poulter
Affiliation:
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex HA1 3UJ, UK
Thomas Lehner
Affiliation:
The Department of Psychiatry and the New York State Psychiatric Institute, Columbia University, New York, NY, USA
Tarulata Shah
Affiliation:
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex HA1 3UJ, UK
Catherine Walsh
Affiliation:
Division of Psychiatry, Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex HA1 3UJ, UK
Angela Boccio-Smith
Affiliation:
Department of Psychiatry, SUNY, Stony Brook, New York, USA
Gail Shields
Affiliation:
Department of Psychiatry, SUNY, Stony Brook, New York, USA
Jurg Ott
Affiliation:
The Department of Psychiatry and the New York State Psychiatric Institute, Columbia University, New York, NY, USA
*
∗Correspondence
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Abstract

We investigated linkage between schizophrenia and the loci DXYS14, DXYS17, and MIC2 within the pseudoautosomal region in 85 families with two or more siblings suffering from schizophrenia or schizoaffective disorder. A maximum lod score of 2.44 was reached at MIC2, with a dominant model of inheritance at a recombination fraction of 0.367 in females and 0.046 in males (a F: M sex ratio > 1, i.e. opposite to that expected with a pseudoautosomal locus). Evidence consistent with linkage (P = 0.01) was also obtained with a sibling pair analysis at the MIC2 locus. These data do not support (although they do not definitively exclude) a locus within the pseudoautosomal region; they are consistent with the presence of a gene that predisposes to schizophrenia in the sex-specific regions of the X and Y chromosomes.

Type
Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 2 , February 1994 , pp. 159 - 164
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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