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Altered dopaminergic function and negative symptoms in drug-free patients with schizophrenia

[123l]-iodobenzamide SPECT study

Published online by Cambridge University Press:  02 January 2018

Michael B. Knable ,
Michael F. Egan ,
Andreas Heinz ,
Julia Gorey ,
Kan Sam Lee ,
Richard Coppola  and
Daniel R. Weinberger
Michael B. Knable*
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Michael F. Egan
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Andreas Heinz
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Julia Gorey
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Kan Sam Lee
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Richard Coppola
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Daniel R. Weinberger
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
*
M. B. Knable, Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 2700 Martin Luther King Jr Ave., S. E., Washington, DC 20032; Fax: 202-373-6214
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Abstract

Background

Previous in vivo studies of schizophrenia with dopamine D2 receptor radioligands have yielded contradictory results. No prior study has used multiple scans to examine within-subject clinical change.

Method

Twenty-one patients were studied with [1231]-iodobenzamide single photon emission computed tomography about two weeks after neuroleptic withdrawal. Thirteen of the 21 completed a second scan about four weeks after neuroleptic withdrawal. Sixteen controls were scanned for comparison.

Results

There was no significant difference between groups in [1231]-iodobenzamide uptake at either scanning session. No significant correlations with demographic variables (age, illness duration, drug-free period), or clinical ratings (positive and negative symptoms, movement disorder) were observed at either scanning session. There was a significant correlation between change in [1231]-iodobenzamide uptake and change in negative symptom ratings for the subjects who underwent two scans (r=0.72, P < 0.05)

Conclusions

Worsening of negative symptoms may be associated with increased availability of striatal D2 receptors, perhaps because of decreased concentrations of endogenous dopamine.

Type
Papers
Information
The British Journal of Psychiatry , Volume 171 , Issue 6 , December 1997 , pp. 574 - 577
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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