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Aldosterone Production Rates in Manic-Depressive Psychosis

Published online by Cambridge University Press:  29 January 2018

M. N. E. Allsopp ,
M. J. Levell ,
S. R. Stitch  and
R. P. Hullin
M. N. E. Allsopp
Affiliation:
Division of Steroid Endocrinology, Department of Chemical Pathology, School of Medicine, Leeds, 2
M. J. Levell
Affiliation:
Division of Steroid Endocrinology, Department of Chemical Pathology, School of Medicine, Leeds, 2
S. R. Stitch
Affiliation:
Division of Steroid Endocrinology, Department of Chemical Pathology, School of Medicine, Leeds, 2
R. P. Hullin
Affiliation:
Department of Biochemistry, School of Medicine, Leeds, 2
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Extract

In 1963 Coppen and Shaw reported that patients with manic-depressive psychosis showed, on clinical recovery, a significant decrease in exchangeable sodium, and in residual sodium (exchangeable minus extracellular sodium), presumed intracellular, per litre of body water. Coppen, Shaw, Malleson and Costain (1966) found a similar type of shift in mania but the deviation from normal was, on average, more extreme. Although low and high sodium diets had no effects on the distribution of sodium in manic-depressive psychotics, the administration of spironolactone resulted in a significant reduction of residual sodium (Coppen, 1970). The possible involvement of aldosterone in these changes led Jenner et al. (1967) to examine aldosterone excretion in a 48-hour cycle patient and Murphy, Goodwin and Bunney (1969) to examine groups of manic and depressed patients. Murphy et al. found lower rates of excretion of aldosterone in depression than in mania, but Jenner et al. found the opposite.

Type
Papers
Information
The British Journal of Psychiatry , Volume 120 , Issue 557 , April 1972 , pp. 399 - 404
Copyright
Copyright © Royal College of Psychiatrists, 1972 

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References

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