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Addison's Disease, Psychosis, and the Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Published online by Cambridge University Press:  29 January 2018

E. G. Lever  and
S. A. Stansfeld
E. G. Lever
Affiliation:
Department of Medicine, King's College Hospital, Denmark Hill, London SE5
S. A. Stansfeld
Affiliation:
Bethlem Royal and Maudsley Hospitals; Current Appointment: General Practice Research Unit, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5
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Summary

A case of tuberculous Addison's disease presenting with psychosis, profound hyponatraemia, and detectable plasma antidiuretic hormone is reported. Clinical and biochemical improvement after corticosteroid replacement was followed by relapse with further psychosis and inappropriate antidiuretic hormone secretion: both were promptly reversed by demethylchlortetracycline. The association of psychological symptoms with Addison's disease, the role of anti-diuretic hormone secretion in Addison's disease, and the inter-relationship between Addison's disease, psychosis and anti-diuretic hormone secretion are discussed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 143 , Issue 4 , October 1983 , pp. 406 - 410
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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