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Acute Rise of Pancreatic Polypeptide after Electroconvulsive Therapy

Published online by Cambridge University Press:  29 January 2018

J. M. Allen ,
T. E. Adrian ,
P. A. Cramer ,
J. Steinert  and
S. R. Bloom
J. M. Allen
Affiliation:
Hammersmith Hospital, Du Cane Road, London, W12
T. E. Adrian
Affiliation:
Department of Medicine, Royal Postgraduate Medical School, London, W12
P. A. Cramer
Affiliation:
St Bernards Hospital, Southall, Middlesex
J. Steinert
Affiliation:
St Bernards Hospital, Southall, Middlesex
S. R. Bloom
Affiliation:
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, W12
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Summary

Plasma pancreatic polypeptide concentrations rise by 320±81 per cent following administration of electroconvulsive therapy. This rise is observed in the first ten minutes despite premedication of patients with 0.6 mg atropine. Pancreatic polypeptide release is dependent on cholinergic tone and is very sensitive to atropine. The dramatic rise in pancreative polypeptide observed following electroconvulsive therapy probably results from vagal stimulation and reflects insufficient atropine premedication.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 141 , Issue 1 , July 1982 , pp. 24 - 26
Copyright
Copyright © The Royal College of Psychiatrists 

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