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Absence of Brain Antibodies in Senile Dementia

Published online by Cambridge University Press:  29 January 2018

Senga Whittingham ,
Vanda Lennon ,
Ian R. Mackay ,
G. Vernon Davies  and
Brian Davies
Senga Whittingham
Affiliation:
Clinical Research Unit of the Walter and Eliza Hall Institute of Medical Research
Vanda Lennon
Affiliation:
Clinical Research Unit of the Walter and Eliza Hall Institute of Medical Research
Ian R. Mackay
Affiliation:
Clinical Research Unit of the Walter and Eliza Hall Institute of Medical Research
G. Vernon Davies
Affiliation:
Department of Psychiatry, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia
Brian Davies
Affiliation:
Department of Psychiatry, University of Melbourne, The Royal Melbourne Hospital, Victoria, Australia
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Extract

In recent years the recognition of autoimmune processes has led to important advances in our understanding of certain diseases of hitherto uncertain causation (Mackay and Burnet, 1963). In psychiatry, schizophrenia has been the main focus of studies of auto-immunity, with Heath and Krupp (1967) reporting positive results of tests for antibodies to brain cell nuclei and Whittingham et al. (1968) reporting negative results. Studies have been described (McAlpine et al., 1965) in which antibodies were detected to whole brain homogen- ates, mostly by complement-fixation, in various disease states that included multiple sclerosis. Wilkinson and Zeromski (1965) found, by immunofluorescence, serum antibodies to cytoplasm of neurones in four of eight patients with carcinomatous neuropathy.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 116 , Issue 533 , April 1970 , pp. 447 - 448
Copyright
Copyright © Royal College of Psychiatrists, 1970 

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References

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Wilkinson, P. C., and Zeromski, J. (1965). ‘Immuno-fluorescent detection of antibodies against neiuones in sensory carcinomatous neuropathy.’ Brain, 28, 529–38.Google Scholar
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