Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-31T20:21:17.448Z Has data issue: false hasContentIssue false
  • English
  • Français

Visual Evoked Potentials in Schizophrenia

Intensity Effects and Hemispheric Asymmetry

Published online by Cambridge University Press:  29 January 2018

J. F. Connolly ,
J. H. Gruzelier ,
R. Manchanda  and
S. R. Hirsch
J. F. Connolly
Affiliation:
Department of Psychiatry, Charing Cross Hospital Medical School, 22–24 St Dunstans Road, London W6 8RP
J. H. Gruzelier
Affiliation:
Department of Psychiatry, Charing Cross Hospital Medical School, 22–24 St Dunstans Road, London W6 8RP
R. Manchanda
Affiliation:
Department of Psychiatry, Charing Cross Hospital Medical School, 22–24 St Dunstans Road, London W6 8RP
S. R. Hirsch
Affiliation:
Department of Psychiatry, Charing Cross Hospital Medical School, 22–24 St Dunstans Road, London W6 8RP
Get access Rights & Permissions [Opens in a new window]

Summary

Visual evoked potentials (VEP) to different flash intensities were recorded at a central site (Cz) plus at homologous temporal and occipital locations in normal and unmedicated schizophrenic subjects. Schizophrenic patients showed an hemisphere asymmetry of the P100–N120 peak-trough amplitude with smaller left but larger right hemisphere amplitudes than normal. Further, two subgroups of patients were found with abnormalities lateralized to the left hemisphere. One group was found to have abnormal P100 amplitude-intensity patterns at the left temporal site while the other group showed deviant N120 amplitude-intensity patterns at the left occipital location. The clinical significance of these results can be seen in the higher nuclear schizophrenia (PSE-CATEGO) scores in the left temporal subgroup and the higher hypomania and situational anxiety scores in the left occipital group. Patients also showed slower than normal P100 and N120 peak latencies.

Type
Papers
Information
The British Journal of Psychiatry , Volume 142 , Issue 2 , February 1983 , pp. 152 - 155
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Buchsbaum, M. (1977) The middle evoked response components in schizophrenia. Schizophrenia Bulletin, 3, 93–104.CrossRefGoogle ScholarPubMed
Buchsbaum, M., Goodwin, F., Murphy, D & Borge, G. (1971) AER in affective disorders. American Journal of Psychiatry, 128, 19–25.Google ScholarPubMed
Buchsbaum, M., Landau, S., Murphy, D. & Goodwin, F. (1973) Average evoked response in bipolar and unipolar affective disorders: Relationship to sex, age of onset, and monamine oxidase. Biological Psychiatry, 7, 199–212.Google Scholar
Buchsbaum, M. & Silverman, J. (1968) Stimulus intensity control and the cortical evoked response. Psychosomatic Medicine, 30, 12–22.CrossRefGoogle Scholar
Connolly, J. (1980) The influence of passive and task conditions on intensity-related changes in exogenous visual event-related potentials (ERPs). International Symposium on the Psychological Significance of Event-Related Potentials, Zeist.CrossRefGoogle Scholar
Connolly, J. & Gruzelier, J. (1982a) Amplitude and latency changes in the visual evoked potential (VEP) to different stimulus intensities. Psychophysiology, in press.CrossRefGoogle Scholar
Connolly, J. & Gruzelier, J. (1982b) A critical examination of augmenting/reducing methodology in schizophrenic patients and controls. In Advances in Biological Psychiatry, vol. 9 (ed. Langnau, ). Basel: Karger.Google Scholar
Connolly, J. & Kleinman, K. M. (1978) A single channel method for recording vertical and lateral eye movements. Electroencephalography and Clinical Neurophysiology, 45, 128–29.CrossRefGoogle ScholarPubMed
Flor-Henry, P. (1969) Psychosis and temporal lobe epilepsy: a controlled investigation. Epilepsia, 10, 363–95.CrossRefGoogle Scholar
Gruzelier, J. H. (1981) Cerebral laterality and psychopathology: fact and fiction. Psychological Medicine, 11, 219–227.Google Scholar
Landau, S. G., Buchsbaum, M. S. Carpenter, W., Strauss, J. & Sacks, M. (1975) Schizophrenia and stimulus intensity control. Archives of General Psychiatry, 32, 1239–45.CrossRefGoogle ScholarPubMed
Petrie, A. (1967) Individuality in Pain and Suffering. Chicago: University of Chicago Press.Google Scholar
Schooler, C., Buchsbaum, M. S. & Carpenter, W. T. Jr. (1976) Evoked response and kinesthetic measures of augmenting/reducing in schizophrenics: replications and extensions. Journal of Nervous and Mental Disease, 163, 221–32.CrossRefGoogle ScholarPubMed
Shagass, C., Roemer, R., Straumanis, J. & Amadeo, M. (1979) Evoked potential evidence of lateralized hemispheric dysfunction in the psychoses. In Gruzelier, J. H. and Flor-Henry, P. (Eds). Hemisphere Asymmetries of Function in Psychopathology, Amsterdam: Elsevier-North Holland.Google Scholar
Tepas, D. I. & Armington, J. C. (1962) Properties of evoked visual potentials. Vision Research, 2, 449–61.CrossRefGoogle Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) The measurement and Classification of Psychiatric Symptoms. London: Cambridge University Press.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.