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Use of Clozapine in a Child with Treatment-Resistant Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Thomas H. MacEwan  and
Michael J. S. Morton
Thomas H. MacEwan
Affiliation:
Department of Family Psychiatry, Glencaple Road, Dumfries, DG1 4TE
Michael J. S. Morton*
Affiliation:
Department of Family Psychiatry, Glencaple Road, Dumfries, DG1 4TE
*
Dr M. J. S. Morton, Ladyfield, Child and Family Health, Glencaple Road, Dumfries DG1 4TE
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Abstract

Background

Schizophrenia can be diagnosed in adults and requires treatment with antipsychotic medication. Clozapine is used effectively in adults with treatment-resistant schizophrenia but little is published on the use of clozapine in children.

Method

Supported by parental consent and a second opinion, standardised observations were used to chart the progress of treatment with clozapine in a child in-patient detained under mental health legislation with severe drug-resistant schizophrenia and tardive dyskinesia.

Results

Sixteen months of clozapine treatment led to significant reduction of symptomatology with marked improvement in social functioning and diminished tardive dyskinesia.

Conclusions

This case illustrates the successful use of clozapine in treatment-resistant childhood schizophrenia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 168 , Issue 3 , March 1996 , pp. 376 - 378
Copyright
Copyright © 1996 The Royal College of Psychiatrists 

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References

Barnes, T. R. E. (1989) A rating scale for drug-induced akathisia. British Journal of Psychiatry, 154, 672–676.CrossRefGoogle ScholarPubMed
Birmaher, B., Baker, R., Kapur, S., et al (1992) Clozapine for the treatment of adolescents with schizophrenia. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 160–164.CrossRefGoogle ScholarPubMed
Frazier, J. A., Gordon, C. T., McKenna, K., et al (1994) An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia. Journal of the American Academy of Child and Adolescent Psychiatry, 33, 658–663.CrossRefGoogle ScholarPubMed
Kane, J., Honigfelt, G., Singer, J., et al (1988), Clozapine for the treatment-resistant schizophrenic. Archives of General Psychiatry, 45, 789–796.CrossRefGoogle ScholarPubMed
McLellan, J. & Werry, J. (1994) Practice parameters for the assessment and treatment of children and adolescents with schizophrenia. Journal of the American Academy of Child and Adolescent Psychiatry, 33, 616–635.CrossRefGoogle Scholar
Mozes, T., Toren, P., Chernauzan, N., et al (1994) Clozapine treatment in very early onset schizophrenia. Journal of the American Academy of Child and Adolescent Psychiatry, 33, 65–70.CrossRefGoogle ScholarPubMed
Schmidt, M. H., Trott, G. E., Blanz, B., et al (1990) Clozapine medication in adolescents. In Psychiatry: A World Perspective. Volume 1, Proceedings of the VIII World Congress of Psychiatry, Athens, October 12–19, 1989 (eds Stefanis, C. N., Rabavilas, A. D. & Soldatos, C. R.), pp. 1100–1104. Amsterdam: Excerpta Medica.Google Scholar
Simpson, G. M. & Angus, J. W. S. (1970) A rating scale for extrapyramidal side effects. Acta Psychiatrica Scandinavica, 212, 11–19.CrossRefGoogle ScholarPubMed
United States Department of Health, Education and Welfare (1976) Abnormal Involuntary Movements Scale (AIMS). In ECDU Assessment Manual (ed. Guy, W.) pp. 534–537.Google Scholar
Woerner, G. W., Mannuzza, S. & Kane, J. M. (1988) Anchoring the BPRS: An aid to improved reliability. Psychopharmacology Bulletin, 24, 112–117.Google ScholarPubMed
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