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Tricyclic Wash-out and Growth Hormone Response to Clonidine

Published online by Cambridge University Press:  02 January 2018

M. Schittecatte ,
G. Charles ,
R. Machowski  and
J. Wilmotte
M. Schittecatte*
Affiliation:
Department of Psychiatry, Vincent Van Gogh Hospital, 55 Rue de l'Hôpital, 6030 Marchienne-Au-Pont, Belgium
G. Charles
Affiliation:
Department of Psychiatry, Vincent Van Gogh Hospital, 55 Rue de l'Hôpital, 6030 Marchienne-Au-Pont, Belgium
R. Machowski
Affiliation:
Department of Psychiatry, Vincent Van Gogh Hospital, 55 Rue de l'Hôpital, 6030 Marchienne-Au-Pont, Belgium
J. Wilmotte
Affiliation:
Department of Psychiatry, Vincent Van Gogh Hospital, 55 Rue de l'Hôpital, 6030 Marchienne-Au-Pont, Belgium
*
∗Correspondence
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Abstract

We have observed a significantly higher growth hormone (GH) response to clonidine administration (150 μg i.v.) in 14 patients with a major depressive disorder who had never received antidepressant therapy than in 14 matched depressive patients who had not received tricyclic drugs for at least 15 days. Compared with a control group of eight subjects, untreated depressed patients, as a group, had a normal response, while matched patients had markedly blunted response. Results for the group of untreated depressed patients showed that some patients had a blunted response while others had a response in the normal range. The results suggest that studies on the GH response to clonidine in psychiatric patients need to take into account the confounding and long-lasting effects of tricyclics.

Type
Papers
Information
The British Journal of Psychiatry , Volume 154 , Issue 6 , June 1989 , pp. 858 - 863
Copyright
Copyright © Royal College of Psychiatrists, 1989 

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