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Tiapride in the Prevention of Relapse in Recently Detoxified Alcoholics

Published online by Cambridge University Press:  02 January 2018

G. K. Shaw ,
S. Waller ,
S. K. Majumdar ,
J. L. Alberts ,
C. J. Latham  and
G. Dunn
G. K. Shaw*
Affiliation:
Bexley Hospital
S. Waller
Affiliation:
Bexley Hospital
S. K. Majumdar
Affiliation:
Bexley Hospital
J. L. Alberts
Affiliation:
Synthelabo Recherche, France
C. J. Latham
Affiliation:
Goldsmiths' College, London
G. Dunn
Affiliation:
Department of Biostatistics, Institute of Psychiatry, London
*
G. K. Shaw, Honorary Consultant Psychiatrist, Bexley Hospital, Old Bexley Lane, Bexley, Kent DA5 2BW
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Abstract

Background

The aim was to investigate the effect of tiapride (100 mg three times a day for at least one month) on outcome following detoxification.

Method

The setting was a tertiary referral centre. The study design was randomised, double-blind, and placebo-controlled. One hundred routinely admitted alcohol-dependent patients were entered, and 54 completed the trial. Outcome was assessed by considering drinking status at three months and six months follow-up, and by comparing psychological status at intake and follow-up using the Crown-Crisp Experiential Index, the Litman Self-esteem scale and a Satisfaction with Life Situations scale. We also compared performance over the six months before admission with the three and six months of follow-up on measures of health, social and drinking variables.

Results

Tiapride proved better (usually at statistically highly significant levels) than placebo at promoting: abstinence, self-esteem, and satisfaction with life situations; and at reducing: alcohol consumption, use of health service resources, and levels of neuroticism.

Conclusions

Tiapride merits serious consideration in the longer-term treatment of alcoholic patients.

Type
Papers
Information
The British Journal of Psychiatry , Volume 165 , Issue 4 , October 1994 , pp. 515 - 523
Copyright
Copyright © Royal College of Psychiatrists, 1994 

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