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Thiothixene and Thioridazine in Anxiety

Published online by Cambridge University Press:  29 January 2018

Karl Rickels ,
Charles C. Weise ,
E. L. Clark ,
B. Wheeler Jenkins ,
Charles K. Rose ,
Howard Rosenfeld  and
Paul E. Gordon
Karl Rickels
Affiliation:
University of Pennsylvania, and Philadelphia, General Hospital, 203 Piersol Building, 3400 Spruce Street, Philadelphia, Pa. 19104, U.S.A.
Charles C. Weise
Affiliation:
Philadelphia General Hospital, Philadelphia, Pennsylvania, 19104, U.S.A.
E. L. Clark
Affiliation:
Philadelphia General Hospital, Philadelphia, Pennsylvania, 19104, U.S.A.
B. Wheeler Jenkins
Affiliation:
Philadelphia General Hospital, Philadelphia, Pennsylvania, 19104, U.S.A.
Charles K. Rose
Affiliation:
Philadelphia General Hospital, Philadelphia, Pennsylvania, 19104, U.S.A.
Howard Rosenfeld
Affiliation:
Philadelphia General Hospital, Philadelphia, Pennsylvania, 19104, U.S.A.
Paul E. Gordon
Affiliation:
Philadelphia General Hospital, Philadelphia, Pennsylvania, 19104, U.S.A.
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Extract

Thiothixene and thioridazine, established anti-psychotic agents (5), have been reported to possess antidepressant (4, 7, 8, 9, 17) and anxiolytic (3, 15, 16) properties. The present study is primarily concerned with the latter claim. It was initiated to assess the role of both these major tranquillizers—thiothixene, a thioxanthene derivative, and thioridazine, a phenothiazine derivative—in the symptomatic treatment of anxious neurotic out-patients.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 125 , Issue 584 , July 1974 , pp. 79 - 87
Copyright
Copyright © Royal College of Psychiatrists, 1974 

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References

1. Bock, R. D. (1963) Multivariate analysis of variance of repeated measurement, in Problems in Measuring Change (ed. Harris, C. W.), p. 85. Madison, Wisconsin: University of Wisconsin Press.Google Scholar
2. Hesbacher, P. T., Rickels, K., Gordon, P. E., Gray, B., Meckelnburg, R., Weise, C. C. & Vandervort, W. J. (1970) Setting, patient, and doctor effects on drug response in neurotic patients: I. Differential attrition, dosage deviation and side reaction responses to treatment. Psychopharmacologia (Berl.), 18, 180.CrossRefGoogle ScholarPubMed
3. Jollen, D. (1971) Clinical experience with thioridazine (Mellaril) in the treatment of anxiety and depression associated with emotional disorders in general practice. Current Therapeutic Research, 13, 111.Google Scholar
4. Kiev, A. (1972) Double-blind comparison of thiothixene and protriptyline in psychotic depression. Diseases of the Nervous System, 33, 811.Google ScholarPubMed
5. Lehmann, H. E. & Ban, T. A. (1969) The thioxanthenes, in Modern Problems of Pharmacopsychiatry, Vol. 2 (eds. Freyhan, F. A., Petrilawitsch, N. & Pichot, P.). Basel: S. Karger.Google Scholar
6. Lipman, R. S., Covi, L., Rickels, K., Uhlenhuth, E. H. & Lazar, R. (1968) Selected measures of change in outpatient drug evaluation, in Psychopharmacology: A Review of Progress, 1957–1967 (eds. Efron, D. H., Cole, J. O., Levine, J. & Wittenborn, J. R.). Public Health Service Publication No. 1836.Google Scholar
7. McLaughlin, B. E. (1969) Therapy for psychotic and psychoneurotic depression with thiothixene and perphenazine-amitriptyline: A double-blind clinical study. Diseases of the Nervous System, 30 (suppl. 2), 85.Google Scholar
8. Overall, J. E., Hollbter, L. E., Meyer, F., Kimbell, I. & Shelton, J. (1964) Imipramine and thioridazine in depressed and schizophrenic patients. Journal of the American Medical Association, 189, 605.Google Scholar
9. Overall, J. Hollbter, L. E., Shelton, J., Kimbell, I. & Pennington, V. (1969) Broad-spectrum screening of psychotherapeutic drugs: Thiothixene as an antipsychotic and antidepressant. Clinical Pharmacology and Therapeutics, 10, 36.CrossRefGoogle ScholarPubMed
10. Rickels, K., Clark, E. L., Etezady, M. H., Sachs, T., Sapra, R. K. & Yee, R. (1970). ‘Butabarbital sodium and chlordiazepoxide in anxious neurotic outpatients: A collaborative controlled study. Clinical Pharmacology and Therapeutics, 11, 538.Google Scholar
11. Rickels, K., Gordon, P. E., Zamostien, B. B., Case, W., Hutchison, J. & Chung, H. (1970). Hydroxyzine and chlordiazepoxide in anxious neurotic outpatients: A collaborative controlled study. Comprehensive Psychiatry, 11, 457.CrossRefGoogle ScholarPubMed
12. Rickels, K., & Howard, K. (1970) The physician questionnaire: A useful tool in psychiatric drug research. Psychopharmacologia (Berl.), 17, 338.Google Scholar
13. Rickels, K., Perloff, M., Perez, L. A., Pereira-Ogan, J. A., Kelly, E. A. & Hesbacher, P. T. (1972) Clomacran in anxious neurotic outpatients: A controlled study. Journal of Clinical Pharmacology, 12, 46.Google Scholar
14. Rickels, K., Weise, C. C., Whalen, E. M., Csanalosi, I., Jenkins, B. W. & Stepansky, W. (1971) Haloperidol in anxiety. Journal of Clinical Pharmacology, 11, 440.Google Scholar
15. Schuster, T. S., Winslow, W. W. & Kellner, R. (1972) A comparison of thioridazine and diazepam in non-psychotic anxiety-depression: A pilot study. Current Therapeutic Research, 14, 131.Google Scholar
16. Simeon, J., Nikolovski, O. T. & Spiro, M. (1970) Thiothixene in the treatment of anxiety and depression in outpatients. Current Therapeutic Research, 12, 369.Google Scholar
17. Wheatley, D. (1972) ‘Thioridazine as an antidepressant. The Practitioner, 209, 95.Google Scholar
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