Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-31T20:49:23.869Z Has data issue: false hasContentIssue false
  • English
  • Français

A Study of Sulphatoxymelatonin Excretion and Gonadotropin Status During Weight Gain in Anorexia Nervosa

Published online by Cambridge University Press:  02 January 2018

J. Bearn ,
J. Treasure ,
M. Murphy ,
C. Franey ,
J. Arendt ,
M. Wheeler  and
S. A. Checkley
J. Bearn*
Affiliation:
Institute of Psychiatry, London
J. Treasure
Affiliation:
Institute of Psychiatry, London
M. Murphy
Affiliation:
Maudsley Hospital, London
C. Franey
Affiliation:
Department of Biochemistry, University of Guildford
J. Arendt
Affiliation:
Department of Biochemistry, University of Guildford
M. Wheeler
Affiliation:
St Thomas' Hopsital, London
S. A. Checkley
Affiliation:
St Thomas' Hopsital, London
*
∗Institute of Psychiatry, De Crespigny Park, London SE5
Get access Rights & Permissions [Opens in a new window]

Abstract

To clarify a controversy as to whether melatonin secretion is related to body weight, urinary sulphatoxymelatonin (aMT6s) excretion was estimated in 10 patients with anorexia nervosa before and after weight gain, and compared with 10 age-matched controls. There was no change in aMT6s excretion after weight gain, and no significant difference between the patients and control groups at either point. Significant increases in plasma LH, FSH, and estradiol were detected after weight gain in anorexic patients, independent of aMT6s excretion.

Type
Annotation
Information
The British Journal of Psychiatry , Volume 152 , Issue 3 , March 1988 , pp. 372 - 376
Copyright
Copyright © Royal College of Psychiatrists, 1988 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM-III). Washington, DC: APA.Google Scholar
Arato, U., Grof, E., Grof, P., Laszlo, I. & Brown, G. W. (1984) Reproducibility of overnight melatonin secretion pattern in healthy men. Advances in the Biosciences, 53, 277–282.Google Scholar
Arendt, J., Hampton, S., English, J., Kwasowski, P. & Marks, V. (1982) 24-hour profiles of melatonin, Cortisol, insulin, C-peptide and GIP following a meal and subsequent fasting. Clinical Endocrinology, 16, 89–95.Google Scholar
Arendt, J., Bojkowski, C., Franey, C., Wright, J. & Marks, V. (1985) Immunoassay of 6-hydroxymelatonin sulphate in human plasma and urine: abolition of the urinary 24-hour rhythm with atenolol. Journal of Clinical Endocrinology and Metabolism, 60, 1166–1173.Google Scholar
Beck-Friis, J., Von Rosen, D., Kjellman, B. F., Ljunggren, J-G. & Wetterberg, L. (1984) Melatonin in relation to body measures, sex, age, season and the use of drugs in patients with major affective disorders and healthy subjects. Psychoneuro-endocrinology, 9, 261–277.Google Scholar
Birau, N., Birau, M. & Schloot, W. (1980) Melatonin rhythms in human serum. Advances in the Biosciences, 29, 287–295.Google Scholar
Brown-Grant, K., Davidson, J. M. & Greig, F. (1973) Induced ovulation in albino rats exposed to constant light. Journal of Endocrinology, 57, 7–22.Google Scholar
Cardinalli, D. P., Valas, N. I. & Ritta, (1981) A biphasic effect of estradiol on serotonin metabolism in the rat pineal organ. Culture Experientia, 37, 203–204.Google Scholar
Carr, D. R., Reppert, S. M., Bullen, B., Skinner, G., Beitins, I., Arnold, M., Rosenblatt, M., Martin, J. B. & McArthur, J. W. (1981) Plasma melatonin increases during exercise in women. Journal of Clinical Endocrinology and Metabolism, 53, 224–225.Google Scholar
Checkley, S. A. (1984) Endocrine change in mental illness. In The Scientific Principles of Psychopathology (eds McGuffin, P., Shanks, M. F. & Hodgson, R. J.). London: Grune & Stratton.Google Scholar
Checkley, S. A., Corn, T. H., Glass, I. B., Thompson, C., Franey, C. & Arendt, J. (1986) Neuroendocrine and other studies of the mechanism of antidepressant action of desipramine. In Antidepressants and Receptor Function (ed. Murphy, D. L.), Ciba Foundation Symposium 123. Chichester: John Wiley & Sons.Google Scholar
Fellenberg, A. L., Phillipou, G. & Seamark, R. F. (1982) Urinary 6-sulphatoxymelatonin excretion during the human menstrual cycle. Clinical Endocrinology, 17, 71–75.Google Scholar
Ferrier, I. N., Arendt, J., Johnstone, E. C. & Crowe, T. J. (1982) Reduced nocturnal melatonin secretion in chronic schizophrenia: relationship to body weight. Clinical Endocrinology, 17, 181–187.Google Scholar
Hamilton, N. (1967) Development of a rating scale for primary depressive illness. British Journal of Social and Clinical Psychology, 6, 278–296.Google Scholar
Lewy, A. J. (1984a) Human melatonin secretion I. A marker for adrenergic functions. In Neurobiology of Mood Disorders (eds Post, R. U. & Ballenger, J. C.), pp. 207–214. Baltimore: Williams & Wilkins.Google Scholar
Lewy, A. J. (1984b) Human melatonin secretion II. A marker of the circadian system and the effects of light, ibid, pp. 215–226.Google Scholar
Reiter, R. J. A Klein, D. C. (1971) Observations on the pineal gland, the harderian glands, the retina and the reproductive organs of adult female rats exposed to continuous light. Journal of Endocrinology, 51, 117–125.CrossRefGoogle ScholarPubMed
Reiter, R. J., Blask, D. E., Johnson, L. Y., Rudeen, P. K., Vaughn, M. K. & Waring, P. J. (1976) Melatonin inhibition of reproduction in the male hamster; its dependency on time of day of administration and on an intact and sympathetically innervated pineal gland. Neuroendocrinology, 22, 107–116.Google Scholar
Reiter, R. J., (1980) The pineal and its hormones in the control of reproduction in mammals. Endocrine Reviews, 1, 109–131.CrossRefGoogle ScholarPubMed
Reiter, R. J., (1981) Reproductive effects of the pineal gland on the Syrian hamster. In The Pineal Gland (ed. Reiter, R. J.) vol. II. Boca Raton, Florida: CRC Press.Google Scholar
Reiter, R. J., (1983) The pineal gland: an intermediary between the environment and the endocrine system. Psychoneuroendocrinohgy, 8, 31–40.Google Scholar
Russell, G. F. M. (1983) Anorexia nervosa and bulimia nervosa. In Handbook of Psychiatry 4: the Neuroses and Personality Disorders (eds Russell, G. F. M. and Hersov, L. A.). Cambridge: Cambridge University Press.Google Scholar
Wetterberg, L., Arendt, J., Paunier, L., Sirzonenko, P. C., Van Donselaar, W. & Heyden, T. (1976) Human serum melatonin changes during the menstrual cycle. Journal of Clinical Endocrinology and Metabolism, 42, 185–188.Google Scholar
Wheeler, M. J., Crisp, A. H., Hus, L. K. G. & Chen, C. N. (1983) Reproductive hormone changes during weight gain in male anorectics. Clinical Endocrinology, 18, 423–429.Google Scholar
Wheeler, M. J. & Luther, F. (1983) Development of testosterone assays for routine use. In Immunoassay for Clinical Chemistry (eds Hunter, W. M. & Corrier, J. E. T.). Edinburgh: Churchill Livingstone.Google Scholar
Wright, J., Aldhous, M., Franey, C., English, J. & Arendt, J. (1986) The effects of exogenous melatonin on endocrine function in man. Clinical Endocrinology, 24, 375–382.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.