Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-22T07:17:50.807Z Has data issue: false hasContentIssue false
  • English
  • Français

Studies Relating to the Clinical Significance of Urinary 3-Methoxy-4-Hydroxyphenylethylene Glycol

Published online by Cambridge University Press:  29 January 2018

D. R. Howlett  and
F. A. Jenner
D. R. Howlett
Affiliation:
University of Sheffield and Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, Sheffield S6 1TP
F. A. Jenner
Affiliation:
University of Sheffield and Medical Research Council Unit for Metabolic Studies in Psychiatry, University Department of Psychiatry, Middlewood Hospital, Sheffield S6 1TP
Get access Rights & Permissions [Opens in a new window]

Abstract

It has been suggested that cerebral noradrenaline turnover in patients can be assessed from the excretion in urine of 3-methoxy-4-hydroxyphenylethylene glycol (MOPEG). Studies were therefore made on the effects of mild exercise on the excretion of the conjugates of MOPEG as this might complicate interpretation. Changes are produced, but there are individual differences between subjects.

Physical fitness was also studied and, although it could not be shown to be the factor explaining differences between different patients, nevertheless it is probably a factor influencing the levels of MOPEG excreted.

The study of the distribution of free MOPEG and its sulphate conjugate in a human brain also raised doubts about the proportions which could have a cerebral origin.

The observations suggest the need for caution in using MOPEG excretion to detect abnormal amine changes in brain. They do not, however, conclusively refute the hypothesis that MOPEG sulphate in urine significantly reflects cerebral noradrenaline activity.

Type
Papers
Information
The British Journal of Psychiatry , Volume 132 , Issue 1 , January 1978 , pp. 49 - 54
Copyright
Copyright © Royal College of Psychiatrists, 1978 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Anton, A. H. & Sayre, D. F. (1962) A study of the factors affecting the aluminium oxide-trihydroxyindole procedure for the analysis of catecholamines. Journal of Pharmacology and Experimental Therapeutics, 138, 360–75.Google ScholarPubMed
Anton, A. H. & Sayre, D. F. (1966) Distribution of metanephrine and normetanephrine in various animals and their analysis in diverse biologic material. Journal of Pharmacology and Experimental Therapeutics, 153, 15–29.Google ScholarPubMed
Bond, P. A., Dimitrakoudi, M., Howlett, D. R. & Jenner, F. A. (1975) The urinary excretion of the sulphate and glucuronide of 3-methoxy-4-hydroxyphenyl glycol in a manic-depressive patient. Psychological Medicine, 5, 279–85.CrossRefGoogle Scholar
Bond, P. A. & Howlett, D. R. (1974) Measurement of the two conjugates of 3-methoxy-4-hydroxyphenyl glycol in urine. Biochemical Medicine, 10, 219–28.CrossRefGoogle Scholar
Bond, P. A., Jenner, F. A. & Sampson, G. A. (1972) Daily variations of the urine content of 3-methoxy-4-hydroxyphenyl glycol in two manic-depressive patients. Psychological Medicine, 2, 81–5.CrossRefGoogle Scholar
Brouha, L. (1943) The step test: a simple method for measuring physical fitness for muscular work in young men. Research Quarterly of the American Association for Health. Physical Education and Welfare, 14, 31–6.Google Scholar
Forbes, G. B. & Bruining, G. J. (1976) Urinary creatinine excretion and lean body mass. American Journal of Clinical Nutrition, 29, 1359–66.CrossRefGoogle ScholarPubMed
Ford, D. H. & Schade, J. P. (1966) Atlas of the Human Brain. Elsevier Publishing Company.Google Scholar
Goode, D. J., Dekirmenjian, H., Meltzer, H. Y. & Maas, J. W. (1973) Relation of exercise to MHPG excretion in normal subjects. Archives of General Psychiatry, 29, 391–6.CrossRefGoogle ScholarPubMed
Haggendal, J. & Werdinius, B. (1966) Dopamine in human urine during muscular work. Acta Physiologica Scandinavica, 66, 223–5.CrossRefGoogle ScholarPubMed
Howlett, D. R. (1975) Chemical and clinical studies of the urinary noradrenaline metabolite, 3-methoxy-4-hydroxyphenyl glycol. Ph.D. Thesis, University of Sheffield.Google Scholar
Howlett, D. R. Jenner, F. A. & Nahorski, S. R. (1975) Urinary 3-methoxy-4-hydroxyphenyl glycol production in mice and rats following intraventricular 6-hydroxydopamine. Journal of Pharmacy and Pharmacology, 27, 447–9.Google Scholar
Jones, F. D., Maas, J. W., Dekirmenjian, H. & Fawcett, J. A. (1973) Urinary catecholamine metabolites during behavioural changes in a patient with manic-depressive cycles. Science, 179, 300–2.CrossRefGoogle Scholar
Joseph, M. H., Baker, H. F., Johnstone, E. C. & Crow, T.J. (1976) Determination of 3-methoxy-4-hydroxyphenyl glycol conjugates in urine. Application to the study of central noradrenaline metabolism in unmedicated chronic schizophrenic patients. Psycho-pharmacology, 51, 47–51.CrossRefGoogle Scholar
Maas, J. W. & Landis, D. H. (1968) In vivo studies of the metabolism of norepinephrine in the central nervous system. Journal of Pharmacology and Experimental Therapeutics, 163, 147–62.Google Scholar
Martin, I. L. & Ansell, G. B. (1973) A sensitive gas chromatographic procedure for the estimation of noradrenaline, dopamine and 5-hydroxytryptamine in rat brain. Biochemical Pharmacology, 22, 521–33.CrossRefGoogle ScholarPubMed
Meek, J. L. & Neff, N. H. (1972) Acidic and neutral metabolites of norepinephrine: their metabolism and transport from brain. Journal of Pharmacology and Experimental Therapeutics, 181, 457–62.Google ScholarPubMed
Neal, C., Smith, C., Dubowski, K. & Naughton, J. (1968) 3-methoxy-3-hydroxymandelic acid excretion during physical exercise. Journal of Applied Physiology, 24, 619–21.CrossRefGoogle ScholarPubMed
Van de Calseyde, J. F., Scholtis, R. J. H., Schmidt, N. A. & Leyton, C J. J. A. (1971) Gas chromatography in the estimation of urinary metancphrines and VMA. Clinica Chimica Acta, 32, 361–6.CrossRefGoogle ScholarPubMed
Von Euler, U. S. & Hellner, S. (1952) Excretion of noradrenaline and adrenaline in muscular work. Acta Physiologica Scandinavica, 26, 183–91.CrossRefGoogle ScholarPubMed
Submit a response

eLetters

No eLetters have been published for this article.